Rajyaguru P and Parker R (2012)

Abstract

A recent report demonstrates that a subset of RGG-motif proteins can bind translation initiation factor eIF4G and repress mRNA translation. This adds to the growing number of roles RGG-motif proteins play in modulating transcription, splicing, mRNA export and now translation. Herein, we review the nature and breadth of functions of RGG-motif proteins. In addition, the interaction of some RGG-motif proteins and other translation repressors with eIF4G highlights the role of eIF4G as a general modulator of mRNA function and not solely as a translation initiation factor.

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Reference Type: Journal Article | Research Support, Non-U.S. Gov't | Review
Authors: Rajyaguru P, Parker R
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Additional Lit For
Review For: NPL3 | SBP1 | TIF4632 | TIF4631 | HRP1 | DED1 | SCD6

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