HRP1 / YOL123W Overview

Standard Name
HRP1 1
Systematic Name
Feature Type
ORF , Verified
Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; required for genome stability; plays a role in copper homeostasis 1 2 3 4 5 6
Name Description
Heterogenous nuclear RibonucleoProtein 1
Comparative Info
Sequence Details


The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

HRP1 is located on the left arm of chromosome XV between TRM11 adoMet-dependent tRNA methyltransferase and SMF1 divalent metal ion transporter; coding sequence is 1605 nucleotides long with 11 SNPs, 2 of which cause amino acid polymorphisms at residues 75 (Ser/Asn) and 455 (Thr/Ile)
Protein Details


Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Hrp1p is 534 amino acids long, of average half-life, and moderate in abundance; abundance drops under nitrogen starvation or treatment with rapamycin, abundance increases under treatment with MMS or HU; contains 2 RNA recognition motif domains; undergoes various post-translational modifications including acetylation, phosphorylation, methylation, succinylation, sumoylation, and ubiquitinylation on 32 residues
Length (a.a.)
Mol. Weight (Da)
Isoelectric Point
Median Abundance (molecules/cell)
13717 +/- 8354
Half-life (hr)


Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results. Click "YeastMine" to view all alleles in YeastMine.

View all HRP1 alleles in SGD search | YeastMine

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

Messenger RNA binding protein involved in mRNA polyadenylation and DNA damage checkpoint effector process; localizes to cytoplasmic stress granule and nucleus

View computational annotations

Molecular Function

Manually Curated

Biological Process

Manually Curated

Cellular Component

Manually Curated


Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Phenotype Details


Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Essential gene; reduced function alleles lead to increased competitive fitness, increased metal resistance, increased heat sensitivity, slow growth; overexpression decreases competitive fitness, metal resistance, UV resistance; heterozygous null is haploproficient, sensitive to starvation; conditional alleles affect size of nucleolus, increase colony sectoring, and decrease resistance to canavanine
Disease Details


Disease Annotations consist of three mandatory components: a gene product, a term from the Disease Ontology (DO) controlled vocabulary and an evidence code. SGD provides manually curated DO Annotations derived from the literature. Click "Disease Details" to view all Disease information and evidence for this locus as well as diseases it shares with other genes.

Yeast HRP1 is homologous to human HNRPDL and HNRNPA1, and has been used to study autosomal dominant limb-girdle muscular dystrophy type 3, amyotrophic lateral sclerosis type 20, and inclusion body myopathy with early-onset Paget disease of bone
Interaction Details


Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

Hrp1p interacts physically with proteins involved in transcription; HRP1 interacts genetically with genes involved in transcription

406 total interactions for 348 unique genes

Physical Interactions

  • Affinity Capture-Luminescence: 1
  • Affinity Capture-MS: 62
  • Affinity Capture-RNA: 11
  • Affinity Capture-Western: 20
  • Biochemical Activity: 7
  • Co-purification: 1
  • PCA: 2
  • Reconstituted Complex: 8
  • Two-hybrid: 7

Genetic Interactions

  • Dosage Growth Defect: 3
  • Dosage Rescue: 1
  • Negative Genetic: 247
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 20
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2
Regulation Details


The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

HRP1 promoter is bound by Tfc7p in response to heat; HRP1 transcription is regulated by Gcr1p and Sin4p; Hrp1p activity is regulated by Cdc28p and protein phosphatase 2A
Expression Details


Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Literature Details


All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.