HSC82 / YMR186W Overview

Standard Name
HSC82 1
Systematic Name
HSP90 3
Feature Type
ORF , Verified
Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication 2 3 4 5 6
HSP82 5
Comparative Info
Sequence Details


The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

HSC82 is on the right arm of chromosome XIII between RTP1 and replication origin ARS1324; coding sequence is 2118 nucleotides long with many, many SNPs; HSC82 has paralog HSP82 that arose from the whole genome duplication
Protein Details


Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Hsc82p is 705 amino acids long, somewhat long-lived, and high in abundance; contains 7 Hsp90 domains; undergoes various post-translational modifications including methylation, acetylation, phosphorylation, succinylation, sumoylation, and ubiquitinylation at 85 residues
Length (a.a.)
Mol. Weight (Da)
Isoelectric Point
Median Abundance (molecules/cell)
134828 +/- 101302
Half-life (hr)


Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results. Click "YeastMine" to view all alleles in YeastMine.

View all HSC82 alleles in SGD search | YeastMine

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

Chaperone protein and ATPase involved in de novo protein folding and protein refolding; involved in proteasome assembly, telomere maintenance, box C/D snoRNP assembly, and the cellular response to heat; localizes to the cytoplasm, mitochondrion, and plasma membrane in high-throughput studies

View computational annotations

Molecular Function

Manually Curated

Biological Process

Manually Curated

Cellular Component

Manually Curated


Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Phenotype Details


Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Non-essential gene; null mutant is sensitive to freeze-thaw; in large-scale experiments null mutants are sensitive to cycloheximide, streptomycin, fluconazole, show decreased telomere lengths and decreased competitive fitness, and increased production and excretion of inositol (Opi-)
Disease Details


Disease Annotations consist of three mandatory components: a gene product, a term from the Disease Ontology (DO) controlled vocabulary and an evidence code. SGD provides manually curated DO Annotations derived from the literature. Click "Disease Details" to view all Disease information and evidence for this locus as well as diseases it shares with other genes.

Yeast HSC82 is homologous to human HSP90AB1, and has been used to study cancer

Manually Curated

Interaction Details


Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

The hsc82 null mutant is viable; the null mutant of paralog hsp82 is viable; the hsc82 hsp82 double mutant is inviable or displays a growth defect; Hsc82p interacts physically with proteins involved in small molecule metabolism, HSC82 interacts genetically with genes involved in transcription

3207 total interactions for 2244 unique genes

Physical Interactions

  • Affinity Capture-MS: 1809
  • Affinity Capture-RNA: 11
  • Affinity Capture-Western: 44
  • Biochemical Activity: 2
  • Co-crystal Structure: 4
  • Co-purification: 2
  • FRET: 3
  • PCA: 7
  • Protein-peptide: 1
  • Proximity Label-MS: 2
  • Reconstituted Complex: 20
  • Two-hybrid: 7

Genetic Interactions

  • Dosage Growth Defect: 4
  • Dosage Lethality: 2
  • Dosage Rescue: 15
  • Negative Genetic: 239
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 11
  • Positive Genetic: 19
  • Synthetic Growth Defect: 978
  • Synthetic Lethality: 19
  • Synthetic Rescue: 6
Regulation Details


The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

Promoter bound by Fhl1p, Gcn5p, Med4p, Reb1p, Spt6p, Sua7p, and Yap6p in response to heat; transcription upregulated by Hsf1p in response to heat; transcription downregulated by Gcn4p in response to boron
Expression Details


Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Summary Paragraph

A summary of the locus, written by SGD Biocurators following a thorough review of the literature. Links to gene names and curated GO terms are included within the Summary Paragraphs.

Last Updated: 2006-06-12

Literature Details


All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.