HSC82 / YMR186W Homology
- Standard Name
- HSC82 1
- Systematic Name
- YMR186W
- SGD ID
- SGD:S000004798
- Aliases
- HSP90 3
- Feature Type
- ORF , Verified
- Description
- Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication 2 3 4 5 6
- Paralog
- HSP82 5
- Comparative Info
-
Homologs
Homology calls are sourced from the Alliance of Genome Resources. Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). The homolog inferences from the different methods have been integrated using the DRSC Integrative Ortholog Prediction Tool (DIOPT), which integrates a number of existing methods including those used by the Alliance: Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, and ZFIN.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| HOMOLOG ID | Species | Gene ID | Gene name | Source |
|---|
Functional Complementation
Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD).
6 entries for 6 complementsIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Species | Gene ID | Strain background | Direction | Details | Source | Reference |
|---|---|---|---|---|---|---|
| Homo sapiens | HGNC:5253 | S288C | other complements yeast | This paper shows that human HSP90alpha complements a yeast hsc82 hsp82 double mutant. | P-POD | Minami Y, et al. (1994) PMID:8289821 |
| Homo sapiens | HGNC:5253 | S288C | other complements yeast | P-POD | MacLean MJ, et al. (2005) PMID:16171778 | |
| Homo sapiens | HGNC:5258 | S288C | other complements yeast | The human HSP90Beta protein complements a yeast hsp82 hsc82 double mutant. | P-POD | Palmer G, et al. (1995) PMID:7637703 |
| Homo sapiens | HGNC:5258 | S288C | other complements yeast | P-POD | Piper PW, et al. (2003) PMID:12527207 | |
| Homo sapiens | HGNC:5258 | S288C | other complements yeast | P-POD | MacLean MJ, et al. (2005) PMID:16171778 | |
| Homo sapiens | HGNC:5258 | Other | other complements yeast | Human HSP90AB1 complements the growth defect of an hsc82-Δ hsp82-Δ double mutant using a 5-FOA-shuffling approach. | SGD | Rehn A, et al. (2020) PMID:32139682 |
Fungal Homologs
Fungal Homology calls are sourced from AllianceMine, which compiles fungal homology calls from FungiDB, CGD, Panther, PomBase, TreeFam, HomoloGene, and SGD.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| HOMOLOG ID | Species | Gene ID | Gene name | Description | Source |
|---|
External Identifiers
List of external identifiers for the protein from various database sources.
19 entries for 9 sourcesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| External ID | Source |
|---|---|
| AN8269 | AspGD |
| orf19.6515 | CGD |
| 1524 | DIP |
| AAA02813.1 | GenBank/EMBL/DDBJ |
| CAA89919.1 | GenBank/EMBL/DDBJ |
| 6323840 | GenBank/EMBL/DDBJ |
| Z49808 | GenBank/EMBL/DDBJ |
| 1708315 | GenBank/EMBL/DDBJ |
| M26044 | GenBank/EMBL/DDBJ |
| 171723 | GenBank/EMBL/DDBJ |
Resources
Homologs
AGD | AnalogYeast | AspGD | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | YGOB | YOGY
Protein Databases
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
Localization
CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRC Public Images | YeastRGB | YPL+
Post-translational Modifications
CoSMoS.c. | PhosphoGRID | PhosphoPep
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi