Literature Help
SIS2 / YKR072C Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
- Unique References
- 170
- Aliases
-
HAL3
8
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Ölmez TT, et al. (2023) Sis2 regulates yeast replicative lifespan in a dose-dependent manner. Nat Commun 14(1):7719 PMID:38012152
- Albacar M, et al. (2022) The toxic effects of yeast Ppz1 phosphatase are counteracted by subcellular relocalization mediated by its regulatory subunit Hal3. FEBS Lett 596(12):1556-1566 PMID:35278214
- Santolaria C, et al. (2022) Functional mapping of the N-terminal region of the yeast moonlighting protein Sis2/Hal3 reveals crucial residues for Ppz1 regulation. FEBS J 289(23):7500-7518 PMID:35811492
- Wang Y, et al. (2022) Rapid Intraspecies Evolution of Fitness Effects of Yeast Genes. Genome Biol Evol 14(5) PMID:35482054
- Olzhausen J, et al. (2021) Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway. Appl Microbiol Biotechnol 105(19):7321-7337 PMID:34491400
- Calafí C, et al. (2020) Overexpression of budding yeast protein phosphatase Ppz1 impairs translation. Biochim Biophys Acta Mol Cell Res 1867(8):118727 PMID:32339526
- Santolaria C, et al. (2018) Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function. Sci Rep 8(1):14701 PMID:30279472
- Anton C, et al. (2017) Involvement of the exomer complex in the polarized transport of Ena1 required for Saccharomyces cerevisiae survival against toxic cations. Mol Biol Cell 28(25):3672-3685 PMID:29021337
- Henriques SF, et al. (2017) Genome-wide search for candidate genes for yeast robustness improvement against formic acid reveals novel susceptibility (Trk1 and positive regulators) and resistance (Haa1-regulon) determinants. Biotechnol Biofuels 10:96 PMID:28428821
- Molero C, et al. (2017) The inhibitory mechanism of Hal3 on the yeast Ppz1 phosphatase: A mutagenesis analysis. Sci Rep 7(1):8819 PMID:28821821
- Mülleder M, et al. (2016) Functional Metabolomics Describes the Yeast Biosynthetic Regulome. Cell 167(2):553-565.e12 PMID:27693354
- Petrényi K, et al. (2016) Analysis of Two Putative Candida albicans Phosphopantothenoylcysteine Decarboxylase / Protein Phosphatase Z Regulatory Subunits Reveals an Unexpected Distribution of Functional Roles. PLoS One 11(8):e0160965 PMID:27504636
- Abrie JA, et al. (2015) Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3. Sci Rep 5:15774 PMID:26514574
- McCormick MA, et al. (2015) A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metab 22(5):895-906 PMID:26456335
- Delaney JR, et al. (2013) Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell 12(1):156-66 PMID:23167605
- González A, et al. (2013) Molecular analysis of a conditional hal3 vhs3 yeast mutant links potassium homeostasis with flocculation and invasiveness. Fungal Genet Biol 53:1-9 PMID:23454581
- Olzhausen J, et al. (2013) Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. FEMS Yeast Res 13(6):565-73 PMID:23789928
- Abrie JA, et al. (2012) Functional mapping of the disparate activities of the yeast moonlighting protein Hal3. Biochem J 442(2):357-68 PMID:22124281
- Marquina M, et al. (2012) Modulation of yeast alkaline cation tolerance by Ypi1 requires calcineurin. Genetics 190(4):1355-64 PMID:22367039
- Merchan S, et al. (2011) Genetic alterations leading to increases in internal potassium concentrations are detrimental for DNA integrity in Saccharomyces cerevisiae. Genes Cells 16(2):152-65 PMID:21143561
- Ivanov MS, et al. (2010) [The protein complex Ppz1p/Hal3p and nonsense suppression efficiency in the yeast Saccharomyces cerevisiae]. Mol Biol (Mosk) 44(6):1018-26 PMID:21290823
- Ruiz A, et al. (2009) Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol 5(12):920-8 PMID:19915539
- Ruotolo R, et al. (2008) Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome Biol 9(4):R67 PMID:18394190
- Aksenova A, et al. (2007) The HAL3-PPZ1 dependent regulation of nonsense suppression efficiency in yeast and its influence on manifestation of the yeast prion-like determinant [ISP(+)]. Genes Cells 12(4):435-45 PMID:17397392
- Ruiz A, et al. (2006) Role of protein phosphatases 2C on tolerance to lithium toxicity in the yeast Saccharomyces cerevisiae. Mol Microbiol 62(1):263-77 PMID:16956380
- Muñoz I, et al. (2004) Functional characterization of the yeast Ppz1 phosphatase inhibitory subunit Hal3: a mutagenesis study. J Biol Chem 279(41):42619-27 PMID:15292171
- Ruiz A, et al. (2004) Functional characterization of the Saccharomyces cerevisiae VHS3 gene: a regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions. J Biol Chem 279(33):34421-30 PMID:15192104
- Muñoz I, et al. (2003) Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae. Yeast 20(2):157-69 PMID:12518319
- Simón E, et al. (2003) Mutagenesis analysis of the yeast Nha1 Na+/H+ antiporter carboxy-terminal tail reveals residues required for function in cell cycle. FEBS Lett 545(2-3):239-45 PMID:12804783
- Yenush L, et al. (2002) The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J 21(5):920-9 PMID:11867520
- Tatusov RL, et al. (2000) The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res 28(1):33-6 PMID:10592175
- Clotet J, et al. (1999) The yeast ser/thr phosphatases sit4 and ppz1 play opposite roles in regulation of the cell cycle. Mol Cell Biol 19(3):2408-15 PMID:10022927
- Hemenway CS and Heitman J (1999) Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae. Mol Gen Genet 261(2):388-401 PMID:10102375
- de Nadal E, et al. (1999) Biochemical and genetic analyses of the role of yeast casein kinase 2 in salt tolerance. J Bacteriol 181(20):6456-62 PMID:10515937
- Masson JY and Ramotar D (1998) The transcriptional activator Imp2p maintains ion homeostasis in Saccharomyces cerevisiae. Genetics 149(2):893-901 PMID:9611200
- de Nadal E, et al. (1998) The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase. Proc Natl Acad Sci U S A 95(13):7357-62 PMID:9636153
- Rios G, et al. (1997) Mechanisms of salt tolerance conferred by overexpression of the HAL1 gene in Saccharomyces cerevisiae. Yeast 13(6):515-28 PMID:9178503
- Rodriguez PL, et al. (1996) CtCdc55p and CtHa13p: two putative regulatory proteins from Candida tropicalis with long acidic domains. Yeast 12(13):1321-9 PMID:8923737
- Di Como CJ, et al. (1995) Overexpression of SIS2, which contains an extremely acidic region, increases the expression of SWI4, CLN1 and CLN2 in sit4 mutants. Genetics 139(1):95-107 PMID:7705654
- Ferrando A, et al. (1995) Regulation of cation transport in Saccharomyces cerevisiae by the salt tolerance gene HAL3. Mol Cell Biol 15(10):5470-81 PMID:7565698
Related Literature
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Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Bravo-Alonso I, et al. (2023) Pathogenic variants of the coenzyme A biosynthesis-associated enzyme phosphopantothenoylcysteine decarboxylase cause autosomal-recessive dilated cardiomyopathy. J Inherit Metab Dis 46(2):261-272 PMID:36564894
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Jakobson CM and Jarosz DF (2019) Molecular Origins of Complex Heritability in Natural Genotype-to-Phenotype Relationships. Cell Syst 8(5):363-379.e3 PMID:31054809
- Zhang C, et al. (2019) Characterization of the atypical Ppz/Hal3 phosphatase system from the pathogenic fungus Cryptococcus neoformans. Mol Microbiol 111(4):898-917 PMID:30536975
- Gazy I, et al. (2013) A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast. G3 (Bethesda) 3(5):917-26 PMID:23704284
- Molero C, et al. (2013) The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities. Mol Microbiol 90(2):367-82 PMID:23962284
- Zaidi I, et al. (2012) The wheat MAP kinase phosphatase 1 confers higher lithium tolerance in yeast. FEMS Yeast Res 12(7):774-84 PMID:22741610
- Delaney JR, et al. (2011) Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell Cycle 10(1):156-65 PMID:21191185
- Fell GL, et al. (2011) Identification of yeast genes involved in k homeostasis: loss of membrane traffic genes affects k uptake. G3 (Bethesda) 1(1):43-56 PMID:22384317
- Reid RJ, et al. (2011) Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res 21(3):477-86 PMID:21173034
- Brooks MA, et al. (2010) Systematic bioinformatics and experimental validation of yeast complexes reduces the rate of attrition during structural investigations. Structure 18(9):1075-82 PMID:20826334
- Olzhausen J, et al. (2009) Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Curr Genet 55(2):163-73 PMID:19266201
- Kvitek DJ, et al. (2008) Variations in stress sensitivity and genomic expression in diverse S. cerevisiae isolates. PLoS Genet 4(10):e1000223 PMID:18927628
- Melamed D, et al. (2008) Yeast translational response to high salinity: global analysis reveals regulation at multiple levels. RNA 14(7):1337-51 PMID:18495938
- Smith ED, et al. (2008) Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res 18(4):564-70 PMID:18340043
- Ferreira TC, et al. (2007) The yeast genome may harbor hypoxia response elements (HRE). Comp Biochem Physiol C Toxicol Pharmacol 146(1-2):255-263 PMID:17035097
- Steigele S, et al. (2007) Comparative analysis of structured RNAs in S. cerevisiae indicates a multitude of different functions. BMC Biol 5:25 PMID:17577407
- Yenush L, et al. (2005) pH-Responsive, posttranslational regulation of the Trk1 potassium transporter by the type 1-related Ppz1 phosphatase. Mol Cell Biol 25(19):8683-92 PMID:16166647
- Begley TJ, et al. (2004) Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping. Mol Cell 16(1):117-25 PMID:15469827
- Riles L, et al. (2004) Large-scale screening of yeast mutants for sensitivity to the IMP dehydrogenase inhibitor 6-azauracil. Yeast 21(3):241-8 PMID:14968429
- Tong AH, et al. (2004) Global mapping of the yeast genetic interaction network. Science 303(5659):808-13 PMID:14764870
- Simón E, et al. (2001) A screening for high copy suppressors of the sit4 hal3 synthetically lethal phenotype reveals a role for the yeast Nha1 antiporter in cell cycle regulation. J Biol Chem 276(32):29740-7 PMID:11382758
- Tong AH, et al. (2001) Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294(5550):2364-8 PMID:11743205
- de Nadal E, et al. (2001) A role for the Ppz Ser/Thr protein phosphatases in the regulation of translation elongation factor 1Balpha. J Biol Chem 276(18):14829-34 PMID:11278758
- Albert A, et al. (2000) The X-ray structure of the FMN-binding protein AtHal3 provides the structural basis for the activity of a regulatory subunit involved in signal transduction. Structure 8(9):961-9 PMID:10986463
- Valens M, et al. (1997) The sequence of a 54.7 kb fragment of yeast chromosome XV reveals the presence of two tRNAs and 24 new open reading frames. Yeast 13(4):379-90 PMID:9133743
- Márquez JA and Serrano R (1996) Multiple transduction pathways regulate the sodium-extrusion gene PMR2/ENA1 during salt stress in yeast. FEBS Lett 382(1-2):89-92 PMID:8612770
Reviews
No reviews curated.
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Download References (.nbib)
- Olzhausen J, et al. (2013) Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. FEMS Yeast Res 13(6):565-73 PMID:23789928
- Ruiz A, et al. (2009) Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol 5(12):920-8 PMID:19915539
- Clotet J, et al. (1999) The yeast ser/thr phosphatases sit4 and ppz1 play opposite roles in regulation of the cell cycle. Mol Cell Biol 19(3):2408-15 PMID:10022927
- de Nadal E, et al. (1998) The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase. Proc Natl Acad Sci U S A 95(13):7357-62 PMID:9636153
- Di Como CJ, et al. (1995) Overexpression of SIS2, which contains an extremely acidic region, increases the expression of SWI4, CLN1 and CLN2 in sit4 mutants. Genetics 139(1):95-107 PMID:7705654
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Download References (.nbib)
- Bravo-Alonso I, et al. (2023) Pathogenic variants of the coenzyme A biosynthesis-associated enzyme phosphopantothenoylcysteine decarboxylase cause autosomal-recessive dilated cardiomyopathy. J Inherit Metab Dis 46(2):261-272 PMID:36564894
- Ölmez TT, et al. (2023) Sis2 regulates yeast replicative lifespan in a dose-dependent manner. Nat Commun 14(1):7719 PMID:38012152
- McCormick MA, et al. (2015) A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metab 22(5):895-906 PMID:26456335
- Delaney JR, et al. (2013) Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell 12(1):156-66 PMID:23167605
- Ruotolo R, et al. (2008) Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome Biol 9(4):R67 PMID:18394190
- Ruiz A, et al. (2006) Role of protein phosphatases 2C on tolerance to lithium toxicity in the yeast Saccharomyces cerevisiae. Mol Microbiol 62(1):263-77 PMID:16956380
- Ferrando A, et al. (1995) Regulation of cation transport in Saccharomyces cerevisiae by the salt tolerance gene HAL3. Mol Cell Biol 15(10):5470-81 PMID:7565698
Disease Literature
Paper(s) associated with one or more pieces of disease evidence in SGD, as found on the Disease page.
No disease literature curated.
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- O'Brien MJ and Ansari A (2024) Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle. Biochim Biophys Acta Proteins Proteom 1872(1):140968 PMID:37863410
- Carey SB, et al. (2023) A synthetic genetic array screen for interactions with the RNA helicase DED1 during cell stress in budding yeast. G3 (Bethesda) 13(1) PMID:36409020
- Cohen N, et al. (2023) A systematic proximity ligation approach to studying protein-substrate specificity identifies the substrate spectrum of the Ssh1 translocon. EMBO J 42(11):e113385 PMID:37073826
- Michaelis AC, et al. (2023) The social and structural architecture of the yeast protein interactome. Nature 624(7990):192-200 PMID:37968396
- Albacar M, et al. (2022) The toxic effects of yeast Ppz1 phosphatase are counteracted by subcellular relocalization mediated by its regulatory subunit Hal3. FEBS Lett 596(12):1556-1566 PMID:35278214
- Casamayor A, et al. (2022) Comparative Analysis of Type 1 and Type Z Protein Phosphatases Reveals D615 as a Key Residue for Ppz1 Regulation. Int J Mol Sci 23(3) PMID:35163251
- Lu PYT, et al. (2022) A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans. Genetics 222(3) PMID:36066422
- Santolaria C, et al. (2022) Functional mapping of the N-terminal region of the yeast moonlighting protein Sis2/Hal3 reveals crucial residues for Ppz1 regulation. FEBS J 289(23):7500-7518 PMID:35811492
- Calafí C, et al. (2020) Overexpression of budding yeast protein phosphatase Ppz1 impairs translation. Biochim Biophys Acta Mol Cell Res 1867(8):118727 PMID:32339526
- Sanders E, et al. (2020) Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1. G3 (Bethesda) 10(12):4359-4368 PMID:33115720
- Espinosa-Cantú A, et al. (2018) Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes. Genetics 208(1):419-431 PMID:29127264
- Kuzmin E, et al. (2018) Systematic analysis of complex genetic interactions. Science 360(6386) PMID:29674565
- Miller JE, et al. (2018) Genome-Wide Mapping of Decay Factor-mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4. G3 (Bethesda) 8(1):315-330 PMID:29158339
- Santolaria C, et al. (2018) Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function. Sci Rep 8(1):14701 PMID:30279472
- Anton C, et al. (2017) Involvement of the exomer complex in the polarized transport of Ena1 required for Saccharomyces cerevisiae survival against toxic cations. Mol Biol Cell 28(25):3672-3685 PMID:29021337
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Shin JJ, et al. (2016) Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets. Dis Model Mech 9(9):1039-49 PMID:27519690
- Abrie JA, et al. (2015) Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3. Sci Rep 5:15774 PMID:26514574
- Dubarry M, et al. (2015) Genetic Networks Required to Coordinate Chromosome Replication by DNA Polymerases α, δ, and ε in Saccharomyces cerevisiae. G3 (Bethesda) 5(10):2187-97 PMID:26297725
- Kırlı K, et al. (2015) A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Elife 4 PMID:26673895
- Aristizabal MJ, et al. (2013) High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8. PLoS Genet 9(8):e1003758 PMID:24009531
- Gazy I, et al. (2013) A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast. G3 (Bethesda) 3(5):917-26 PMID:23704284
- González A, et al. (2013) Molecular analysis of a conditional hal3 vhs3 yeast mutant links potassium homeostasis with flocculation and invasiveness. Fungal Genet Biol 53:1-9 PMID:23454581
- Makanae K, et al. (2013) Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method. Genome Res 23(2):300-11 PMID:23275495
- Mitchell SF, et al. (2013) Global analysis of yeast mRNPs. Nat Struct Mol Biol 20(1):127-33 PMID:23222640
- Molero C, et al. (2013) The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities. Mol Microbiol 90(2):367-82 PMID:23962284
- Olzhausen J, et al. (2013) Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. FEMS Yeast Res 13(6):565-73 PMID:23789928
- Abrie JA, et al. (2012) Functional mapping of the disparate activities of the yeast moonlighting protein Hal3. Biochem J 442(2):357-68 PMID:22124281
- Friederichs JM, et al. (2012) Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1. G3 (Bethesda) 2(12):1703-18 PMID:23275891
- Schlecht U, et al. (2012) Multiplex assay for condition-dependent changes in protein-protein interactions. Proc Natl Acad Sci U S A 109(23):9213-8 PMID:22615397
- Sharifpoor S, et al. (2012) Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Genome Res 22(4):791-801 PMID:22282571
- Addinall SG, et al. (2011) Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects. PLoS Genet 7(4):e1001362 PMID:21490951
- Echtenkamp FJ, et al. (2011) Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Mol Cell 43(2):229-41 PMID:21777812
- Finnigan GC, et al. (2011) A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae. Genetics 187(3):771-83 PMID:21196517
- Merchan S, et al. (2011) Genetic alterations leading to increases in internal potassium concentrations are detrimental for DNA integrity in Saccharomyces cerevisiae. Genes Cells 16(2):152-65 PMID:21143561
- Reid RJ, et al. (2011) Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res 21(3):477-86 PMID:21173034
- Scherrer T, et al. (2011) Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Genome Biol 12(1):R3 PMID:21232131
- Breitkreutz A, et al. (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328(5981):1043-6 PMID:20489023
- Costanzo M, et al. (2010) The genetic landscape of a cell. Science 327(5964):425-31 PMID:20093466
- Kim JH, et al. (2009) The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization. J Biol Chem 284(16):10400-8 PMID:19233841
- Leidel S, et al. (2009) Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. Nature 458(7235):228-32 PMID:19145231
- Ruiz A, et al. (2009) Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol 5(12):920-8 PMID:19915539
- Hasegawa Y, et al. (2008) Distinct roles for Khd1p in the localization and expression of bud-localized mRNAs in yeast. RNA 14(11):2333-47 PMID:18805955
- Hoke SM, et al. (2008) Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes. BMC Genet 9:46 PMID:18616809
- Lin YY, et al. (2008) A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation. Genes Dev 22(15):2062-74 PMID:18676811
- Tarassov K, et al. (2008) An in vivo map of the yeast protein interactome. Science 320(5882):1465-70 PMID:18467557
- Yu H, et al. (2008) High-quality binary protein interaction map of the yeast interactome network. Science 322(5898):104-10 PMID:18719252
- Collins SR, et al. (2007) Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature 446(7137):806-10 PMID:17314980
- Stirling PC, et al. (2007) Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression. Mol Biol Cell 18(6):2336-45 PMID:17429077
- Krogan NJ, et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature 440(7084):637-43 PMID:16554755
- Pan X, et al. (2006) A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell 124(5):1069-81 PMID:16487579
- Ruiz A, et al. (2006) Role of protein phosphatases 2C on tolerance to lithium toxicity in the yeast Saccharomyces cerevisiae. Mol Microbiol 62(1):263-77 PMID:16956380
- Loeillet S, et al. (2005) Genetic network interactions among replication, repair and nuclear pore deficiencies in yeast. DNA Repair (Amst) 4(4):459-68 PMID:15725626
- Ptacek J, et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84 PMID:16319894
- Yenush L, et al. (2005) pH-Responsive, posttranslational regulation of the Trk1 potassium transporter by the type 1-related Ppz1 phosphatase. Mol Cell Biol 25(19):8683-92 PMID:16166647
- Krogan NJ, et al. (2004) High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell 13(2):225-39 PMID:14759368
- Lesage G, et al. (2004) Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin. Genetics 167(1):35-49 PMID:15166135
- Muñoz I, et al. (2004) Functional characterization of the yeast Ppz1 phosphatase inhibitory subunit Hal3: a mutagenesis study. J Biol Chem 279(41):42619-27 PMID:15292171
- Ruiz A, et al. (2004) Functional characterization of the Saccharomyces cerevisiae VHS3 gene: a regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions. J Biol Chem 279(33):34421-30 PMID:15192104
- Tong AH, et al. (2004) Global mapping of the yeast genetic interaction network. Science 303(5659):808-13 PMID:14764870
- Hazbun TR, et al. (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65 PMID:14690591
- Muñoz I, et al. (2003) Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae. Yeast 20(2):157-69 PMID:12518319
- Simón E, et al. (2003) Mutagenesis analysis of the yeast Nha1 Na+/H+ antiporter carboxy-terminal tail reveals residues required for function in cell cycle. FEBS Lett 545(2-3):239-45 PMID:12804783
- Yenush L, et al. (2002) The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J 21(5):920-9 PMID:11867520
- Simón E, et al. (2001) A screening for high copy suppressors of the sit4 hal3 synthetically lethal phenotype reveals a role for the yeast Nha1 antiporter in cell cycle regulation. J Biol Chem 276(32):29740-7 PMID:11382758
- Tong AH, et al. (2001) Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294(5550):2364-8 PMID:11743205
- Clotet J, et al. (1999) The yeast ser/thr phosphatases sit4 and ppz1 play opposite roles in regulation of the cell cycle. Mol Cell Biol 19(3):2408-15 PMID:10022927
- Hemenway CS and Heitman J (1999) Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae. Mol Gen Genet 261(2):388-401 PMID:10102375
- de Nadal E, et al. (1998) The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase. Proc Natl Acad Sci U S A 95(13):7357-62 PMID:9636153
- Masson JY and Ramotar D (1998) The transcriptional activator Imp2p maintains ion homeostasis in Saccharomyces cerevisiae. Genetics 149(2):893-901 PMID:9611200
- Rios G, et al. (1997) Mechanisms of salt tolerance conferred by overexpression of the HAL1 gene in Saccharomyces cerevisiae. Yeast 13(6):515-28 PMID:9178503
- Luke MM, et al. (1996) The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase. Mol Cell Biol 16(6):2744-55 PMID:8649382
- Di Como CJ, et al. (1995) Overexpression of SIS2, which contains an extremely acidic region, increases the expression of SWI4, CLN1 and CLN2 in sit4 mutants. Genetics 139(1):95-107 PMID:7705654
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
Download References (.nbib)
- Zhang F, et al. (2025) The Yeast Gsk-3 Kinase Mck1 Is Necessary for Cell Wall Remodeling in Glucose-Starved and Cell Wall-Stressed Cells. Int J Mol Sci 26(8) PMID:40332024
- King GA, et al. (2023) Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization. J Cell Biol 222(2) PMID:36515990
- Leutert M, et al. (2023) The regulatory landscape of the yeast phosphoproteome. Nat Struct Mol Biol 30(11):1761-1773 PMID:37845410
- Dokládal L, et al. (2021) Phosphoproteomic responses of TORC1 target kinases reveal discrete and convergent mechanisms that orchestrate the quiescence program in yeast. Cell Rep 37(13):110149 PMID:34965436
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Zhou X, et al. (2021) Cross-compartment signal propagation in the mitotic exit network. Elife 10 PMID:33481703
- MacGilvray ME, et al. (2020) Phosphoproteome Response to Dithiothreitol Reveals Unique Versus Shared Features of Saccharomyces cerevisiae Stress Responses. J Proteome Res 19(8):3405-3417 PMID:32597660
- Chen YC, et al. (2018) Glucose intake hampers PKA-regulated HSP90 chaperone activity. Elife 7 PMID:30516470
- Swaney DL, et al. (2013) Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nat Methods 10(7):676-82 PMID:23749301
- Pultz D, et al. (2012) Global mapping of protein phosphorylation events identifies Ste20, Sch9 and the cell-cycle regulatory kinases Cdc28/Pho85 as mediators of fatty acid starvation responses in Saccharomyces cerevisiae. Mol Biosyst 8(3):796-803 PMID:22218487
- Breitkreutz A, et al. (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328(5981):1043-6 PMID:20489023
- Soulard A, et al. (2010) The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates. Mol Biol Cell 21(19):3475-86 PMID:20702584
- Holt LJ, et al. (2009) Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science 325(5948):1682-6 PMID:19779198
- Huber A, et al. (2009) Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev 23(16):1929-43 PMID:19684113
- Albuquerque CP, et al. (2008) A multidimensional chromatography technology for in-depth phosphoproteome analysis. Mol Cell Proteomics 7(7):1389-96 PMID:18407956
Functional Complementation Annotations Literature
Paper(s) associated with one or more pieces of functional complementation annotations evidence in SGD.
No functional complementation annotations literature curated.
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
Download References (.nbib)
- Fierling N, et al. (2024) Global deletome profile of Saccharomyces cerevisiae exposed to lithium. Metallomics 16(1) PMID:38142127
- King GA, et al. (2023) Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization. J Cell Biol 222(2) PMID:36515990
- Li Q, et al. (2023) Genome-wide identification of resistance genes and cellular analysis of key gene knockout strain under 5-hydroxymethylfurfural stress in Saccharomyces cerevisiae. BMC Microbiol 23(1):382 PMID:38049732
- Ölmez TT, et al. (2023) Sis2 regulates yeast replicative lifespan in a dose-dependent manner. Nat Commun 14(1):7719 PMID:38012152
- Coey CT and Clark DJ (2022) A systematic genome-wide account of binding sites for the model transcription factor Gcn4. Genome Res 32(2):367-377 PMID:34916251
- Dokládal L, et al. (2021) Phosphoproteomic responses of TORC1 target kinases reveal discrete and convergent mechanisms that orchestrate the quiescence program in yeast. Cell Rep 37(13):110149 PMID:34965436
- Papagiannidis D, et al. (2021) Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex. EMBO J 40(22):e107958 PMID:34617598
- Campos SE, et al. (2018) Genomewide mechanisms of chronological longevity by dietary restriction in budding yeast. Aging Cell 17(3):e12749 PMID:29575540
- Rawal Y, et al. (2018) Gcn4 Binding in Coding Regions Can Activate Internal and Canonical 5' Promoters in Yeast. Mol Cell 70(2):297-311.e4 PMID:29628310
- Mülleder M, et al. (2016) Functional Metabolomics Describes the Yeast Biosynthetic Regulome. Cell 167(2):553-565.e12 PMID:27693354
- North M, et al. (2016) Functional Toxicogenomic Profiling Expands Insight into Modulators of Formaldehyde Toxicity in Yeast. Front Genet 7:200 PMID:27909446
- Ostrow AZ, et al. (2014) Fkh1 and Fkh2 bind multiple chromosomal elements in the S. cerevisiae genome with distinct specificities and cell cycle dynamics. PLoS One 9(2):e87647 PMID:24504085
- Gaytán BD, et al. (2013) Functional profiling discovers the dieldrin organochlorinated pesticide affects leucine availability in yeast. Toxicol Sci 132(2):347-58 PMID:23358190
- Gaytán BD, et al. (2013) A genome-wide screen identifies yeast genes required for tolerance to technical toxaphene, an organochlorinated pesticide mixture. PLoS One 8(11):e81253 PMID:24260565
- Jarolim S, et al. (2013) Saccharomyces cerevisiae genes involved in survival of heat shock. G3 (Bethesda) 3(12):2321-33 PMID:24142923
- Marek A and Korona R (2013) Restricted pleiotropy facilitates mutational erosion of major life-history traits. Evolution 67(11):3077-86 PMID:24151994
- Michaillat L and Mayer A (2013) Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiae. PLoS One 8(2):e54160 PMID:23383298
- Samanfar B, et al. (2013) Large-scale investigation of oxygen response mutants in Saccharomyces cerevisiae. Mol Biosyst 9(6):1351-9 PMID:23467670
- Suzuki T, et al. (2013) Disruption of multiple genes whose deletion causes lactic-acid resistance improves lactic-acid resistance and productivity in Saccharomyces cerevisiae. J Biosci Bioeng 115(5):467-74 PMID:23290995
- Davey HM, et al. (2012) Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability. Environ Microbiol 14(5):1249-60 PMID:22356628
- O'Connor ST, et al. (2012) Genome-Wide Functional and Stress Response Profiling Reveals Toxic Mechanism and Genes Required for Tolerance to Benzo[a]pyrene in S. cerevisiae. Front Genet 3:316 PMID:23403841
- Pir P, et al. (2012) The genetic control of growth rate: a systems biology study in yeast. BMC Syst Biol 6:4 PMID:22244311
- Qian W, et al. (2012) The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep 2(5):1399-410 PMID:23103169
- Delaney JR, et al. (2011) Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell Cycle 10(1):156-65 PMID:21191185
- Fell GL, et al. (2011) Identification of yeast genes involved in k homeostasis: loss of membrane traffic genes affects k uptake. G3 (Bethesda) 1(1):43-56 PMID:22384317
- Venters BJ, et al. (2011) A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell 41(4):480-92 PMID:21329885
- Yoshikawa K, et al. (2011) Comprehensive phenotypic analysis of single-gene deletion and overexpression strains of Saccharomyces cerevisiae. Yeast 28(5):349-61 PMID:21341307
- Kapitzky L, et al. (2010) Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol 6:451 PMID:21179023
- Pan X, et al. (2010) Trivalent arsenic inhibits the functions of chaperonin complex. Genetics 186(2):725-34 PMID:20660648
- Holbein S, et al. (2009) Cordycepin interferes with 3' end formation in yeast independently of its potential to terminate RNA chain elongation. RNA 15(5):837-49 PMID:19324962
- Holt LJ, et al. (2009) Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science 325(5948):1682-6 PMID:19779198
- Westmoreland TJ, et al. (2009) Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae. PLoS One 4(6):e5830 PMID:19503795
- Yoshikawa K, et al. (2009) Comprehensive phenotypic analysis for identification of genes affecting growth under ethanol stress in Saccharomyces cerevisiae. FEMS Yeast Res 9(1):32-44 PMID:19054128
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- Cipollina C, et al. (2008) Saccharomyces cerevisiae SFP1: at the crossroads of central metabolism and ribosome biogenesis. Microbiology (Reading) 154(Pt 6):1686-1699 PMID:18524923
- Gustavsson M and Ronne H (2008) Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast. RNA 14(4):666-74 PMID:18314501
- Smith ED, et al. (2008) Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res 18(4):564-70 PMID:18340043
- Brown JA, et al. (2006) Global analysis of gene function in yeast by quantitative phenotypic profiling. Mol Syst Biol 2:2006.0001 PMID:16738548
- Kawahata M, et al. (2006) Yeast genes involved in response to lactic acid and acetic acid: acidic conditions caused by the organic acids in Saccharomyces cerevisiae cultures induce expression of intracellular metal metabolism genes regulated by Aft1p. FEMS Yeast Res 6(6):924-36 PMID:16911514
- Lum PY, et al. (2004) Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell 116(1):121-37 PMID:14718172
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549