SRO9 / YCL037C Overview

Standard Name
SRO9 1
Systematic Name
Feature Type
ORF , Verified
Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; role in preventing L-A mycovirus pathogenesis; SRO9 has a paralog, SLF1, that arose from the whole genome duplication 1 2 3 4 5 6
Name Description
Suppressor of rho3 1
SLF1 4
Comparative Info
Sequence Details


The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

SRO9 is located on the left arm of chromosome III between ATG22 vacuolar membrane protein and uncharacterized gene GFD2; coding sequence is 1305 nucleotides long with 2 SNPs, one of which causes a Gln/Lys polymorphism at residue 216; SRO9 has paralog SLF1 from the whole genome duplication
Protein Details


Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Sro9p is 434 amino acids long, slightly longer-lived, high in abundance; acetylated on 3 lysines, ubiquitinylated on 7 lysines, phosphorylated on 33 residues
Length (a.a.)
Mol. Weight (Da)
Isoelectric Point
Median Abundance (molecules/cell)
26393 +/- 9666
Half-life (hr)


Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results. Click "YeastMine" to view all alleles in YeastMine.

View all SRO9 alleles in SGD search | YeastMine

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

RNA-binding protein involved in cytoplasmic translation; localizes to polysomes and cytoplasmic stress granules

View computational annotations

Molecular Function

Manually Curated

Biological Process

Manually Curated

Cellular Component

Manually Curated


Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Phenotype Details


Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Non-essential gene; null mutant displays slow growth, abnormal chitin deposition, heat sensitivity, moderate defect in vacuolar fragmentation, significant growth reduction relative to wt after treatment with isobutanol, decreased biofilm formation, decreased oxidative stress resistance, increased resistance to fluconazole, decreased resistance to camptothecin, cycloheximide, caffeine, hydroxyurea, UV; heterozygous null is haploproficient
Interaction Details


Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

The sro9 null mutant is viable; the null mutant of paralog slf1 is viable; the sro9 slf1 double mutant has not been annotated for phenotype.

1141 total interactions for 995 unique genes

Physical Interactions

  • Affinity Capture-MS: 118
  • Affinity Capture-RNA: 815
  • Affinity Capture-Western: 26
  • Biochemical Activity: 1
  • Co-purification: 1
  • PCA: 14
  • Proximity Label-MS: 8

Genetic Interactions

  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Dosage Rescue: 7
  • Negative Genetic: 83
  • Phenotypic Enhancement: 1
  • Positive Genetic: 26
  • Synthetic Growth Defect: 18
  • Synthetic Lethality: 12
  • Synthetic Rescue: 8
Regulation Details


The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

SRO9 promoter is bound by Gcn5p, Med4p, and Ume6p in response to heat; SRO9 transcription is regulated by Fkh1p in response to starvation; Sro9 protein activity is regulated by Cdc28p
Expression Details


Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Literature Details


All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.