UME6 / YDR207C Overview

Standard Name
UME6 1
Systematic Name
CAR80 1 2 , NIM2 , RIM16 25
Feature Type
ORF , Verified
Rpd3L histone deacetylase complex subunit; key transcriptional regulator of early meiotic genes; involved in chromatin remodeling and transcriptional repression via DNA looping; binds URS1 upstream regulatory sequence, represses transcription by recruiting conserved histone deacetylase Rpd3p (through co-repressor Sin3p) and chromatin-remodeling factor Isw2p; couples metabolic responses to nutritional cues with initiation and progression of meiosis 2 3 4 5 6 7 8 9 11 12 13
Name Description
Unscheduled Meiotic gene Expression 10
Comparative Info
Sequence Details


The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

Protein Details


Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Length (a.a.)
Mol. Weight (Da)
Isoelectric Point
Median Abundance (molecules/cell)
1199 +/- 740
Half-life (hr)


Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results. Click "YeastMine" to view all alleles in YeastMine.

View all UME6 alleles in SGD search | YeastMine

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

Sequence-specific DNA-binding transcription factor involved in chromatin remodeling as it relates to the regulation of pseudohyphal growth, mitosis, meiosis, sporulation, lipid metabolism and nitrogen catabolite repression; component of the Rpd3L histone deacetylase complex

View computational annotations

Cellular Component

Manually Curated


Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Phenotype Details


Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Non-essential gene; null mutant glows slowly, has decreased ethanol tolerance, abnormal morphology of vacuoles and lipid particles, shortened lifespan, and is sensitive to DNA-damaging agents, caffeine, metals, heat, osmotic stress, desiccation, antimalarial quinine, and TOR inhibitor rapamycin; diploid mutants are defective in sporulation
Interaction Details


Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

1209 total interactions for 807 unique genes

Physical Interactions

  • Affinity Capture-MS: 43
  • Affinity Capture-RNA: 7
  • Affinity Capture-Western: 7
  • Biochemical Activity: 10
  • Co-localization: 2
  • Co-purification: 1
  • Reconstituted Complex: 6
  • Two-hybrid: 15

Genetic Interactions

  • Dosage Lethality: 2
  • Dosage Rescue: 3
  • Negative Genetic: 837
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 9
  • Positive Genetic: 203
  • Synthetic Growth Defect: 25
  • Synthetic Lethality: 18
  • Synthetic Rescue: 13
Regulation Details


The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

UME6 encodes a transcription factor that is a member of the C6 zinc finger class, containing a DNA binding domain also known as the Zn2Cys6 binuclear zinc cluster or zinc knuckle. Ume6p is a key regulator of meiosis and sporulation, repressing early meiosis-specific promoters during vegetative growth by binding to upstream repression sequences (URS1) and recruiting the Rpd3p-Sin3p histone deacetylase complex and the Isw2 chromatin remodeling complex. An important target of repression is NDT80, encoding a transcriptional activator that is central to establishing the commitment to meiosis. Ume6p has both positive and negative regulatory targets among genes involved in carbon and nitrogen metabolism, and may help to coordinate metabolic activity with meiosis. It is also involved in control of the induction of autophagy, via repression of ATG8 transcription. Transcriptional repression by Ume6p during vegetative growth is lifted by Ume6p degradation. In a two-step process, about 50% of Ume6p is destroyed after the transition to nonfermentable carbon sources, in a process that requires Ume6p acetylation by the SAGA acetyltransferase complex. In the absence of a nitrogen source during early meiosis, the remaining Ume6p interacts with the Ime1p transcription factor to trigger its complete destruction.
Expression Details


Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Summary Paragraph

A summary of the locus, written by SGD Biocurators following a thorough review of the literature. Links to gene names and curated GO terms are included within the Summary Paragraphs.

Last Updated: 2002-04-01

Literature Details


All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.