Primary Literature
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- Yeh FL, et al. (2021) Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling. Nat Commun 12(1):3082 PMID: 34035302
- Zhang Z, et al. (2021) Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature 596(7871):296-300 PMID: 34349264
- Plaschka C, et al. (2018) Prespliceosome structure provides insights into spliceosome assembly and regulation. Nature 559(7714):419-422 PMID: 29995849
- Zhan X, et al. (2018) Structures of the human pre-catalytic spliceosome and its precursor spliceosome. Cell Res 28(12):1129-1140 PMID: 30315277
- Bertram K, et al. (2017) Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Cell 170(4):701-713.e11 PMID: 28781166
- Plaschka C, et al. (2017) Structure of a pre-catalytic spliceosome. Nature 546(7660):617-621 PMID: 28530653
- Ulrich AK and Wahl MC (2017) Human MFAP1 is a cryptic ortholog of the Saccharomyces cerevisiae Spp381 splicing factor. BMC Evol Biol 17(1):91 PMID: 28335716
- Agafonov DE, et al. (2016) Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 351(6280):1416-20 PMID: 26912367
- Cornilescu G, et al. (2016) Structural Analysis of Multi-Helical RNAs by NMR-SAXS/WAXS: Application to the U4/U6 di-snRNA. J Mol Biol 428(5 Pt A):777-789 PMID: 26655855
- Didychuk AL, et al. (2016) Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly. Nucleic Acids Res 44(3):1398-410 PMID: 26673715
- Hoskins AA, et al. (2016) Single molecule analysis reveals reversible and irreversible steps during spliceosome activation. Elife 5 PMID: 27244240
- Nguyen THD, et al. (2016) Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution. Nature 530(7590):298-302 PMID: 26829225
- Nguyen TH, et al. (2016) CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast. Curr Opin Struct Biol 36:48-57 PMID: 26803803
- Rodgers ML, et al. (2016) A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex. Nucleic Acids Res 44(22):10912-10928 PMID: 27484481
- Wan R, et al. (2016) The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis. Science 351(6272):466-75 PMID: 26743623
- Nguyen TH, et al. (2015) The architecture of the spliceosomal U4/U6.U5 tri-snRNP. Nature 523(7558):47-52 PMID: 26106855
- Huang YH, et al. (2014) Sad1 counteracts Brr2-mediated dissociation of U4/U6.U5 in tri-snRNP homeostasis. Mol Cell Biol 34(2):210-20 PMID: 24190974
- Price AM, et al. (2014) An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8. RNA 20(1):46-60 PMID: 24231520
- Nancollis V, et al. (2013) The U5 snRNA internal loop 1 is a platform for Brr2, Snu114 and Prp8 protein binding during U5 snRNP assembly. J Cell Biochem 114(12):2770-84 PMID: 23857713
- Chen HC and Cheng SC (2012) Functional roles of protein splicing factors. Biosci Rep 32(4):345-59 PMID: 22762203
- Fabrizio P, et al. (2009) The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Mol Cell 36(4):593-608 PMID: 19941820
- Yang K, et al. (2008) Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins. Proc Natl Acad Sci U S A 105(37):13817-22 PMID: 18779563
- Simeoni F and Divita G (2007) The Dim protein family: from structure to splicing. Cell Mol Life Sci 64(16):2079-89 PMID: 17558560
- Carnahan RH, et al. (2005) Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex. Eukaryot Cell 4(3):577-87 PMID: 15755920
- Dobbyn HC and O'Keefe RT (2004) Analysis of Snu13p mutations reveals differential interactions with the U4 snRNA and U3 snoRNA. RNA 10(2):308-20 PMID: 14730029
- Verdone L, et al. (2004) Lsm proteins promote regeneration of pre-mRNA splicing activity. Curr Biol 14(16):1487-91 PMID: 15324666
- Wilkinson CR, et al. (2004) Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast. Curr Biol 14(24):2283-8 PMID: 15620657
- Bartels C, et al. (2003) Mutagenesis suggests several roles of Snu114p in pre-mRNA splicing. J Biol Chem 278(30):28324-34 PMID: 12736260
- Wang Q, et al. (2003) The Clf1p splicing factor promotes spliceosome assembly through N-terminal tetratricopeptide repeat contacts. J Biol Chem 278(10):7875-83 PMID: 12509417
- Zhang YZ, et al. (2003) Structure, stability, and function of hDim1 investigated by NMR, circular dichroism, and mutational analysis. Biochemistry 42(32):9609-18 PMID: 12911302
- Mougin A, et al. (2002) Direct probing of RNA structure and RNA-protein interactions in purified HeLa cell's and yeast spliceosomal U4/U6.U5 tri-snRNP particles. J Mol Biol 317(5):631-49 PMID: 11955014
- Peng R, et al. (2002) PSF and p54nrb bind a conserved stem in U5 snRNA. RNA 8(10):1334-47 PMID: 12403470
- Stevens SW, et al. (2002) Composition and functional characterization of the yeast spliceosomal penta-snRNP. Mol Cell 9(1):31-44 PMID: 11804584
- Gottschalk A, et al. (2001) The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p. RNA 7(11):1554-65 PMID: 11720285
- Gottschalk A, et al. (2001) A novel yeast U2 snRNP protein, Snu17p, is required for the first catalytic step of splicing and for progression of spliceosome assembly. Mol Cell Biol 21(9):3037-46 PMID: 11287609
- Johnson TL and Abelson J (2001) Characterization of U4 and U6 interactions with the 5' splice site using a S. cerevisiae in vitro trans-splicing system. Genes Dev 15(15):1957-70 PMID: 11485990
- Makarova OV, et al. (2001) The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes. EMBO J 20(10):2553-63 PMID: 11350945
- Stevens SW, et al. (2001) Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae. RNA 7(11):1543-53 PMID: 11720284
- van Nues RW and Beggs JD (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157(4):1451-67 PMID: 11290703
- Käufer NF and Potashkin J (2000) Analysis of the splicing machinery in fission yeast: a comparison with budding yeast and mammals. Nucleic Acids Res 28(16):3003-10 PMID: 10931913
- Makarov EM, et al. (2000) The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions. J Mol Biol 298(4):567-75 PMID: 10788320
- Watkins NJ, et al. (2000) A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP. Cell 103(3):457-66 PMID: 11081632
- Achsel T, et al. (1999) A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. EMBO J 18(20):5789-802 PMID: 10523320
- Bracken AP and Bond U (1999) Reassembly and protection of small nuclear ribonucleoprotein particles by heat shock proteins in yeast cells. RNA 5(12):1586-96 PMID: 10606269
- Chung S, et al. (1999) Yeast ortholog of the Drosophila crooked neck protein promotes spliceosome assembly through stable U4/U6.U5 snRNP addition. RNA 5(8):1042-54 PMID: 10445879
- Gottschalk A, et al. (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48 PMID: 10449419
- Luukkonen BG and Séraphin B (1999) A conditional U5 snRNA mutation affecting pre-mRNA splicing and nuclear pre-mRNA retention identifies SSD1/SRK1 as a general splicing mutant suppressor. Nucleic Acids Res 27(17):3455-65 PMID: 10446233
- Lybarger S, et al. (1999) Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation. Mol Cell Biol 19(1):577-84 PMID: 9858581
- Mayes AE, et al. (1999) Characterization of Sm-like proteins in yeast and their association with U6 snRNA. EMBO J 18(15):4321-31 PMID: 10428970
- Nottrott S, et al. (1999) Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA. EMBO J 18(21):6119-33 PMID: 10545122
- Stevens SW and Abelson J (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31 PMID: 10377396
- Vidal VP, et al. (1999) Characterization of U6 snRNA-protein interactions. RNA 5(11):1470-81 PMID: 10580475
- Xie J, et al. (1998) Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociation. EMBO J 17(10):2938-46 PMID: 9582287
- Anthony JG, et al. (1997) The yeast Prp3 protein is a U4/U6 snRNP protein necessary for integrity of the U4/U6 snRNP and the U4/U6.U5 tri-snRNP. RNA 3(10):1143-52 PMID: 9326489
- Lauber J, et al. (1997) The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p. RNA 3(8):926-41 PMID: 9257651
- Teigelkamp S, et al. (1997) The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p. RNA 3(11):1313-26 PMID: 9409622
- Wang A, et al. (1997) Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome. Hum Mol Genet 6(12):2117-26 PMID: 9328476
- Fabrizio P, et al. (1994) Isolation of S. cerevisiae snRNPs: comparison of U1 and U4/U6.U5 to their human counterparts. Science 264(5156):261-5 PMID: 8146658
- Galisson F and Legrain P (1993) The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP. Nucleic Acids Res 21(7):1555-62 PMID: 8479905
- Brown JD and Beggs JD (1992) Roles of PRP8 protein in the assembly of splicing complexes. EMBO J 11(10):3721-9 PMID: 1396567