Small ribosomal subunit processome

Small ribosomal subunit processome Literature

Unique References: 84
Aliases: SSU processome complex , Small-subunit processome

Primary Literature

Buzovetsky O and Klinge S (2025) Helicase-mediated mechanism of SSU processome maturation and disassembly. Nature 648(8094):746-754 PMID: 41162712
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Lau B, et al. (2021) Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome. Mol Cell 81(2):293-303.e4 PMID: 33326748
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Kargas V, et al. (2019) Mechanism of completion of peptidyltransferase centre assembly in eukaryotes. Elife 8 PMID: 31115337
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Linnemann J, et al. (2019) Impact of two neighbouring ribosomal protein clusters on biogenesis factor binding and assembly of yeast late small ribosomal subunit precursors. PLoS One 14(1):e0203415 PMID: 30653518
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Chaker-Margot M (2018) Assembly of the small ribosomal subunit in yeast: mechanism and regulation. RNA 24(7):881-891 PMID: 29712726
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Vincent NG, et al. (2018) The SSU processome interactome in Saccharomyces cerevisiae reveals novel protein subcomplexes. RNA 24(1):77-89 PMID: 29054886
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Barandun J, et al. (2017) The complete structure of the small-subunit processome. Nat Struct Mol Biol 24(11):944-953 PMID: 28945246
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Chaker-Margot M, et al. (2017) Architecture of the yeast small subunit processome. Science 355(6321) PMID: 27980088
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Sun Q, et al. (2017) Molecular architecture of the 90S small subunit pre-ribosome. Elife 6 PMID: 28244370
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Khoshnevis S, et al. (2016) The DEAD-box Protein Rok1 Orchestrates 40S and 60S Ribosome Assembly by Promoting the Release of Rrp5 from Pre-40S Ribosomes to Allow for 60S Maturation. PLoS Biol 14(6):e1002480 PMID: 27280440
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Banerjee D, et al. (2015) Limited portability of G-patch domains in regulators of the Prp43 RNA helicase required for pre-mRNA splicing and ribosomal RNA maturation in Saccharomyces cerevisiae. Genetics 200(1):135-47 PMID: 25808954
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Chaker-Margot M, et al. (2015) Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome biogenesis. Nat Struct Mol Biol 22(11):920-3 PMID: 26479197
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Chen YL, et al. (2014) The telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis. Nucleic Acids Res 42(11):7330-45 PMID: 24823796
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Moriggi G, et al. (2014) Rrp12 and the Exportin Crm1 participate in late assembly events in the nucleolus during 40S ribosomal subunit biogenesis. PLoS Genet 10(12):e1004836 PMID: 25474739
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Jakob S, et al. (2012) Interrelationships between yeast ribosomal protein assembly events and transient ribosome biogenesis factors interactions in early pre-ribosomes. PLoS One 7(3):e32552 PMID: 22431976
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Pérez-Fernández J, et al. (2011) Elucidation of the assembly events required for the recruitment of Utp20, Imp4 and Bms1 onto nascent pre-ribosomes. Nucleic Acids Res 39(18):8105-21 PMID: 21724601
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Li Z, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213 PMID: 19806183
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Segerstolpe A, et al. (2008) Mrd1p binds to pre-rRNA early during transcription independent of U3 snoRNA and is required for compaction of the pre-rRNA into small subunit processomes. Nucleic Acids Res 36(13):4364-80 PMID: 18586827
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Pérez-Fernández J, et al. (2007) The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism. Mol Cell Biol 27(15):5414-29 PMID: 17515605
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Bernstein KA, et al. (2004) The small-subunit processome is a ribosome assembly intermediate. Eukaryot Cell 3(6):1619-26 PMID: 15590835
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Gallagher JE, et al. (2004) RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components. Genes Dev 18(20):2506-17 PMID: 15489292
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Léger-Silvestre I, et al. (2004) The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast. EMBO J 23(12):2336-47 PMID: 15167894
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Dragon F, et al. (2002) A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature 417(6892):967-70 PMID: 12068309
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Grandi P, et al. (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15 PMID: 12150911
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Additional Literature

Braun CM, et al. (2020) Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit. Nucleic Acids Res 48(1):405-420 PMID: 31745560

Clerget G, et al. (2020) Synergistic defects in pre-rRNA processing from mutations in the U3-specific protein Rrp9 and U3 snoRNA. Nucleic Acids Res 48(7):3848-3868 PMID: 31996908

Davila Gallesio J, et al. (2020) Sgd1 is an MIF4G domain-containing cofactor of the RNA helicase Fal1 and associates with the 5' domain of the 18S rRNA sequence. RNA Biol 17(4):539-553 PMID: 31994962

Cepeda LPP, et al. (2019) The ribosome assembly factor Nop53 controls association of the RNA exosome with pre-60S particles in yeast. J Biol Chem 294(50):19365-19380 PMID: 31662437

Ramos-Sáenz A, et al. (2019) Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae. RNA 25(11):1561-1575 PMID: 31413149

Tardu M, et al. (2019) Identification and Quantification of Modified Nucleosides in Saccharomyces cerevisiae mRNAs. ACS Chem Biol 14(7):1403-1409 PMID: 31243956

An W, et al. (2018) Structural and functional analysis of Utp24, an endonuclease for processing 18S ribosomal RNA. PLoS One 13(4):e0195723 PMID: 29641590

Black JJ, et al. (2018) Utp14 interaction with the small subunit processome. RNA 24(9):1214-1228 PMID: 29925570

Shu S and Ye K (2018) Structural and functional analysis of ribosome assembly factor Efg1. Nucleic Acids Res 46(4):2096-2106 PMID: 29361028

Belhabich-Baumas K, et al. (2017) The Rio1p ATPase hinders premature entry into translation of late pre-40S pre-ribosomal particles. Nucleic Acids Res 45(18):10824-10836 PMID: 28977579

Heuer A, et al. (2017) Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae. Elife 6 PMID: 29155690

Johnson MC, et al. (2017) Structural Heterogeneity in Pre-40S Ribosomes. Structure 25(2):329-340 PMID: 28111018

Sturm M, et al. (2017) Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly. Nat Commun 8(1):2213 PMID: 29263326

Wells GR, et al. (2017) The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain. Nucleic Acids Res 45(8):4796-4809 PMID: 28082392

Fischer U, et al. (2015) A non-canonical mechanism for Crm1-export cargo complex assembly. Elife 4 PMID: 25895666

Schütz S, et al. (2014) A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly. Elife 3:e03473 PMID: 25144938

Dembowski JA, et al. (2013) Has1 regulates consecutive maturation and processing steps for assembly of 60S ribosomal subunits. Nucleic Acids Res 41(16):7889-904 PMID: 23788678

Young CL, et al. (2013) Cofactor-dependent specificity of a DEAD-box protein. Proc Natl Acad Sci U S A 110(29):E2668-76 PMID: 23630256

Faza MB, et al. (2012) Role of Mex67-Mtr2 in the nuclear export of 40S pre-ribosomes. PLoS Genet 8(8):e1002915 PMID: 22956913

Schilling V, et al. (2012) Genetic interactions of yeast NEP1 (EMG1), encoding an essential factor in ribosome biogenesis. Yeast 29(5):167-83 PMID: 22588997

Strunk BS, et al. (2012) A translation-like cycle is a quality control checkpoint for maturing 40S ribosome subunits. Cell 150(1):111-21 PMID: 22770215

Alexandrov A, et al. (2011) Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex. Genes Dev 25(10):1078-90 PMID: 21576267

Campbell MG and Karbstein K (2011) Protein-protein interactions within late pre-40S ribosomes. PLoS One 6(1):e16194 PMID: 21283762

Choque E, et al. (2011) The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces cerevisiae. RNA Biol 8(6):1158-72 PMID: 21941128

Schwer B, et al. (2011) Composition of yeast snRNPs and snoRNPs in the absence of trimethylguanosine caps reveals nuclear cap binding protein as a gained U1 component implicated in the cold-sensitivity of tgs1Δ cells. Nucleic Acids Res 39(15):6715-28 PMID: 21558325

Charette JM and Baserga SJ (2010) The DEAD-box RNA helicase-like Utp25 is an SSU processome component. RNA 16(11):2156-69 PMID: 20884785

Gérus M, et al. (2010) Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production of the 40S ribosomal subunit. Mol Cell Biol 30(5):1130-44 PMID: 20038530

Goldfeder MB and Oliveira CC (2010) Utp25p, a nucleolar Saccharomyces cerevisiae protein, interacts with U3 snoRNP subunits and affects processing of the 35S pre-rRNA. FEBS J 277(13):2838-52 PMID: 20528918

Merl J, et al. (2010) Analysis of ribosome biogenesis factor-modules in yeast cells depleted from pre-ribosomes. Nucleic Acids Res 38(9):3068-80 PMID: 20100801

Kemmler S, et al. (2009) Yvh1 is required for a late maturation step in the 60S biogenesis pathway. J Cell Biol 186(6):863-80 PMID: 19797079

Rodríguez-Mateos M, et al. (2009) The amino terminal domain from Mrt4 protein can functionally replace the RNA binding domain of the ribosomal P0 protein. Nucleic Acids Res 37(11):3514-21 PMID: 19346338

Tarassov K, et al. (2008) An in vivo map of the yeast protein interactome. Science 320(5882):1465-70 PMID: 18467557

Dez C, et al. (2007) Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation. RNA 13(9):1516-27 PMID: 17652137

Thomson E, et al. (2007) Nop9 is an RNA binding protein present in pre-40S ribosomes and required for 18S rRNA synthesis in yeast. RNA 13(12):2165-74 PMID: 17956976

Bleichert F, et al. (2006) The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Proc Natl Acad Sci U S A 103(25):9464-9 PMID: 16769905

Gavin AC, et al. (2006) Proteome survey reveals modularity of the yeast cell machinery. Nature 440(7084):631-6 PMID: 16429126

Granneman S, et al. (2006) The nucleolar protein Esf2 interacts directly with the DExD/H box RNA helicase, Dbp8, to stimulate ATP hydrolysis. Nucleic Acids Res 34(10):3189-99 PMID: 16772403

Krogan NJ, et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature 440(7084):637-43 PMID: 16554755

Rempola B, et al. (2006) Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing. Biochem Biophys Res Commun 346(2):546-54 PMID: 16762320

Schäfer T, et al. (2006) Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit. Nature 441(7093):651-5 PMID: 16738661

Hoang T, et al. (2005) Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Mol Cell Biol 25(13):5523-34 PMID: 15964808

Peng WT, et al. (2004) ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae. Nucleic Acids Res 32(6):1993-9 PMID: 15056729

Chen W, et al. (2003) Enp1, a yeast protein associated with U3 and U14 snoRNAs, is required for pre-rRNA processing and 40S subunit synthesis. Nucleic Acids Res 31(2):690-9 PMID: 12527778

Hazbun TR, et al. (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65 PMID: 14690591

Gavin AC, et al. (2002) Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415(6868):141-7 PMID: 11805826

Guglielmi B and Werner M (2002) The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition. J Biol Chem 277(38):35712-9 PMID: 12107183

Ho Y, et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415(6868):180-3 PMID: 11805837

Jin SB, et al. (2002) Mrd1p is required for processing of pre-rRNA and for maintenance of steady-state levels of 40 S ribosomal subunits in yeast. J Biol Chem 277(21):18431-9 PMID: 11884397

Shimizu K, et al. (2002) The fifth essential DNA polymerase phi in Saccharomyces cerevisiae is localized to the nucleolus and plays an important role in synthesis of rRNA. Proc Natl Acad Sci U S A 99(14):9133-8 PMID: 12093911

Daugeron MC and Linder P (2001) Characterization and mutational analysis of yeast Dbp8p, a putative RNA helicase involved in ribosome biogenesis. Nucleic Acids Res 29(5):1144-55 PMID: 11222764

Harnpicharnchai P, et al. (2001) Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell 8(3):505-15 PMID: 11583614

Steinmetz EJ, et al. (2001) RNA-binding protein Nrd1 directs poly(A)-independent 3'-end formation of RNA polymerase II transcripts. Nature 413(6853):327-31 PMID: 11565036

Gromadka R and Rytka J (2000) The KRR1 gene encodes a protein required for 18S rRNA synthesis and 40S ribosomal subunit assembly in Saccharomyces cerevisiae. Acta Biochim Pol 47(4):993-1005 PMID: 11996121

Sasaki T, et al. (2000) Yeast Krr1p physically and functionally interacts with a novel essential Kri1p, and both proteins are required for 40S ribosome biogenesis in the nucleolus. Mol Cell Biol 20(21):7971-9 PMID: 11027267

Lafontaine DL and Tollervey D (1999) Nop58p is a common component of the box C+D snoRNPs that is required for snoRNA stability. RNA 5(3):455-67 PMID: 10094313

Wiederkehr T, et al. (1998) Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation. RNA 4(11):1357-72 PMID: 9814757

Ursic D, et al. (1997) The yeast SEN1 gene is required for the processing of diverse RNA classes. Nucleic Acids Res 25(23):4778-85 PMID: 9365256

Venema J, et al. (1997) Rok1p is a putative RNA helicase required for rRNA processing. Mol Cell Biol 17(6):3398-407 PMID: 9154839

Jansen R, et al. (1993) A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing. EMBO J 12(6):2549-58 PMID: 8508778

Reviews

Venema J and Tollervey D (1999) Ribosome synthesis in Saccharomyces cerevisiae. Annu Rev Genet 33:261-311 PMID: 10690410

Small ribosomal subunit processome Literature TEXT HERE

Primary Literature TEXT HERE

Additional Literature TEXT HERE

Reviews

Small ribosomal subunit processome Literature

Primary Literature

Additional Literature