Reference: Peng WT, et al. (2004) ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae. Nucleic Acids Res 32(6):1993-9

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Abstract


We report that Esf1p (Ydr365cp), an essential, evolutionarily conserved nucleolar protein, is required for the biogenesis of 18S rRNA in Saccharomyces cerevisiae. Depletion of Esf1p resulted in delayed processing of 35S precursor and a striking loss of 18S rRNA. Esf1p physically associated with ribosomal proteins and proteins involved in 18S rRNA biogenesis. Consistent with its role in 18S rRNA biogenesis, Esf1p also physically associated with U3 and U14 snoRNAs, but did not appear to be a core component of the SSU processome. These data indicate that Esf1p plays a direct role in early pre-rRNA processing.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Peng WT, Krogan NJ, Richards DP, Greenblatt JF, Hughes TR
Primary Lit For
ESF1
Additional Lit For
SNR128 | SNR17B | SNR17A | Small ribosomal subunit processome

Gene Ontology Annotations 2 entries for 1 gene


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Gene/ComplexQualifierGene Ontology TermAnnotation ExtensionEvidenceSourceAssigned On
ESF1enablesRNA bindingIDASGD2013-08-07
ESF1involved inrRNA processingIMPSGD2013-08-07
Showing 1 to 2 of 2 entries

Phenotype Annotations 1 entry for 1 gene


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GenePhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetails
ESF1RNA accumulation: increased
Reporter: 35S pre-rRNA
classical geneticsrepressibleOtherDetails: abundance of 35S pre-rRNA is increased; virtually complete loss of 20S amd 27SA2 precursors
Showing 1 to 1 of 1 entries

Interaction Annotations


Genetic Interactions

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Interactor Interactor Allele Assay Annotation Action Phenotype SGA score P-value Source Reference

Physical Interactions 12 entries for 13 genes

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InteractorInteractorAssayAnnotationActionModification
ESF1PUF6Affinity Capture-MSmanually curatedBait-HitNo Modification
ESF1NSR1Affinity Capture-MSmanually curatedBait-HitNo Modification
ESF1RPL3Affinity Capture-MSmanually curatedBait-HitNo Modification
ESF1RPP0Affinity Capture-MSmanually curatedBait-HitNo Modification
ESF1RPS3Affinity Capture-MSmanually curatedBait-HitNo Modification
ESF1RPS2Affinity Capture-MSmanually curatedBait-HitNo Modification
ESF1RLP7Affinity Capture-MSmanually curatedBait-HitNo Modification
ESF1RPL10Affinity Capture-MSmanually curatedBait-HitNo Modification
ESF1UTP22Affinity Capture-MSmanually curatedBait-HitNo Modification
KRR1ESF1Affinity Capture-MSmanually curatedHit-BaitNo Modification
Showing 1 to 10 of 12 entries