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Small ribosomal subunit processome, variant 1 Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Required for the processing, assembly and maturation of nascent pre-ribosomal RNA to form the small ribosomal subunit (SSU). The SSU processome is a giant particle composed of numerous ribosome assembly factors, including the UTP-A (CPX-1409), UTP-B (CPX-1410), UTP-C (CPX-772/CPX-771/CPX-773) and MPP10 (CPX-1893) complexes, the U3 small nucleolar ribonucleoprotein (snoRNP) and many individual proteins. Acts in the nucleolus to cleave the polycistronic precursor pre-rRNA in the 5-prime external transcribed spacer (ETS) sequence and in the internal transcribed spacer 1 (ITS1) sequence, to separate small and large subunit biogenesis. The nascent SSU is then exported from the nucleolus to the cytoplasm, where the final cleavage occurs to form the mature 40S SSU containing the 18S rRNA. The nuclease FCF1 and the molecular motor BMS1 cause structural changes within the mature processome which facilitate the subsequent cleavage reactions.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

RNA binding, cellular nitrogen compound metabolic process, rRNA processing, nucleolus, organelle, preribosome, ribonucleoprotein complex, small-subunit processome