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  • Author: Longo VD
  • References

Author: Longo VD


References 59 references


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  • Mirisola MG and Longo VD (2024) Inactivation of Ymr1, Sjl2/3 phosphatases promotes stress resistance and longevity in wild type and Ras2G19V yeast. Biomed J 47(2):100694 PMID:38154617
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  • Di Tano M and Longo VD (2022) Fasting and cancer: from yeast to mammals. Int Rev Cell Mol Biol 373:81-106 PMID:36283768
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  • Mirisola MG and Longo VD (2022) Yeast Chronological Lifespan: Longevity Regulatory Genes and Mechanisms. Cells 11(10) PMID:35626750
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  • Di Biase S, et al. (2017) Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS Biol 15(3):e2001951 PMID:28358805
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  • Balasubramanian P and Longo VD (2016) Growth factors, aging and age-related diseases. Growth Horm IGF Res 28:66-8 PMID:26883276
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  • Brandhorst S, et al. (2015) A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab 22(1):86-99 PMID:26094889
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  • Hu J, et al. (2014) Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity. Aging Cell 13(3):457-67 PMID:24649827
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  • Mirisola MG, et al. (2014) Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging. PLoS Genet 10(2):e1004113 PMID:24516402
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  • Mirzaei H and Longo VD (2014) Acetyl-CoA synthetase is a conserved regulator of autophagy and life span. Cell Metab 19(4):555-7 PMID:24703691
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  • Mirzaei H, et al. (2014) Protein and amino acid restriction, aging and disease: from yeast to humans. Trends Endocrinol Metab 25(11):558-66 PMID:25153840
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  • Hu J, et al. (2013) Assessing chronological aging in Saccharomyces cerevisiae. Methods Mol Biol 965:463-72 PMID:23296677
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  • Mirisola MG and Longo VD (2013) A radical signal activates the epigenetic regulation of longevity. Cell Metab 17(6):812-813 PMID:23747240
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  • Longo VD and Fabrizio P (2012) Chronological aging in Saccharomyces cerevisiae. Subcell Biochem 57:101-21 PMID:22094419
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  • Longo VD, et al. (2012) Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab 16(1):18-31 PMID:22768836
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  • Mirisola MG and Longo VD (2012) Acetic acid and acidification accelerate chronological and replicative aging in yeast. Cell Cycle 11(19):3532-3 PMID:22951542
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  • Mirisola MG and Longo VD (2011) Conserved role of Ras-GEFs in promoting aging: from yeast to mice. Aging (Albany NY) 3(4):340-3 PMID:21732566
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  • Sehati S, et al. (2011) Metabolic alterations in yeast lacking copper-zinc superoxide dismutase. Free Radic Biol Med 50(11):1591-8 PMID:21397007
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  • Wei M, et al. (2011) Studying age-dependent genomic instability using the S. cerevisiae chronological lifespan model. J Vis Exp PMID:21989366
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  • Fabrizio P, et al. (2010) Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS Genet 6(7):e1001024 PMID:20657825
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  • Fontana L, et al. (2010) Extending healthy life span--from yeast to humans. Science 328(5976):321-6 PMID:20395504
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  • Ge H, et al. (2010) Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant. Nucleic Acids Res 38(1):143-58 PMID:19880387
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  • Lee C, et al. (2010) Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res 70(4):1564-72 PMID:20145127
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  • Longo VD, et al. (2010) Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span. Autophagy 6(8):1227-8 PMID:20953148
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  • Parrella E and Longo VD (2010) Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal 10:161-77 PMID:20098959
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  • Longo VD (2009) Linking sirtuins, IGF-I signaling, and starvation. Exp Gerontol 44(1-2):70-4 PMID:18638538
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  • Madia F, et al. (2009) Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism. J Cell Biol 186(4):509-23 PMID:19687253
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  • Wei M, et al. (2009) Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. PLoS Genet 5(5):e1000467 PMID:19424415
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  • Fabrizio P and Longo VD (2008) Chronological aging-induced apoptosis in yeast. Biochim Biophys Acta 1783(7):1280-5 PMID:18445486
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  • Li Y, et al. (2008) SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab 8(1):38-48 PMID:18590691
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  • Madia F, et al. (2008) Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol 180(1):67-81 PMID:18195102
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  • Parrella E and Longo VD (2008) The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease. Methods 46(4):256-62 PMID:18930829
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  • Raffaghello L, et al. (2008) Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A 105(24):8215-20 PMID:18378900
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  • Wei M, et al. (2008) Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet 4(1):e13 PMID:18225956
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  • Cheng C, et al. (2007) Significant and systematic expression differentiation in long-lived yeast strains. PLoS One 2(10):e1095 PMID:17971858
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  • Cheng C, et al. (2007) Inference of transcription modification in long-live yeast strains from their expression profiles. BMC Genomics 8:219 PMID:17617911
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  • Fabrizio P and Longo VD (2007) The chronological life span of Saccharomyces cerevisiae. Methods Mol Biol 371:89-95 PMID:17634576
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  • Madia F, et al. (2007) A simple model system for age-dependent DNA damage and cancer. Mech Ageing Dev 128(1):45-9 PMID:17118426
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  • Longo VD and Kennedy BK (2006) Sirtuins in aging and age-related disease. Cell 126(2):257-68 PMID:16873059
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  • Fabrizio P, et al. (2005) Analysis of gene expression profile in yeast aging chronologically. Mech Ageing Dev 126(1):11-6 PMID:15610757
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  • Fabrizio P, et al. (2005) Sir2 blocks extreme life-span extension. Cell 123(4):655-67 PMID:16286010
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  • Longo VD, et al. (2005) Programmed and altruistic ageing. Nat Rev Genet 6(11):866-72 PMID:16304601
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  • Skulachev VP and Longo VD (2005) Aging as a mitochondria-mediated atavistic program: can aging be switched off? Ann N Y Acad Sci 1057:145-64 PMID:16399892
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  • Fabrizio P, et al. (2004) Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. J Cell Biol 166(7):1055-67 PMID:15452146
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  • Fabrizio P, et al. (2004) Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. FEBS Lett 557(1-3):136-42 PMID:14741356
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  • Longo VD (2004) Ras: the other pro-aging pathway. Sci Aging Knowledge Environ 2004(39):pe36 PMID:15456908
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  • Fabrizio P and Longo VD (2003) The chronological life span of Saccharomyces cerevisiae. Aging Cell 2(2):73-81 PMID:12882320
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  • Fabrizio P, et al. (2003) SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics 163(1):35-46 PMID:12586694
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  • Gendron CM, et al. (2003) Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic. Mech Ageing Dev 124(10-12):1059-63 PMID:14659594
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  • Longo VD (2003) The Ras and Sch9 pathways regulate stress resistance and longevity. Exp Gerontol 38(7):807-11 PMID:12855292
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  • Longo VD and Finch CE (2003) Evolutionary medicine: from dwarf model systems to healthy centenarians? Science 299(5611):1342-6 PMID:12610293
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  • Longo VD and Fabrizio P (2002) Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans? Cell Mol Life Sci 59(6):903-8 PMID:12169020
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  • Xie Z, et al. (2002) Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. J Neurosci 22(9):3484-92 PMID:11978825
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  • Longo VD (1999) Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells. Neurobiol Aging 20(5):479-86 PMID:10638521
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  • Longo VD, et al. (1999) Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys 365(1):131-42 PMID:10222047
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  • Vaupel JW, et al. (1998) Biodemographic trajectories of longevity. Science 280(5365):855-60 PMID:9599158
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  • Longo VD, et al. (1997) Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. J Cell Biol 137(7):1581-8 PMID:9199172
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  • Longo VD, et al. (1996) Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. J Biol Chem 271(21):12275-80 PMID:8647826
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