Reference: Röther S, et al. (2010)
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Abstract
Diverse steps in gene expression are tightly coupled. Curiously, the La-motif-containing protein Sro9 has been shown to play a role in transcription and translation. Here, we show that Sro9 interacts with nuclear and cytoplasmic protein complexes involved in gene expression. In addition, Sro9 shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner. Importantly, Sro9 is recruited to transcribed genes. However, whole genome expression analysis shows that loss of Sro9 function does not greatly change the level of specific transcripts indicating that Sro9 does not markedly affect their synthesis and/or stability. Taken together, Sro9 might bind to the mRNP already during transcription and accompany the mature mRNP to the cytoplasm where it modulates translation of the mRNA.
- Reference Type
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Journal Article |
Research Support, Non-U.S. Gov't
- Authors
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Röther S,
Burkert C,
Brünger KM,
Mayer A,
Kieser A,
Strässer K
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- SRO9
- CTK1 | NPL3 | MTR2 | RPO21 | RPS4A | HPR1 | MEX67 | MEX67-MTR2 mRNA nuclear export factor complex
Gene Ontology Annotations
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| Evidence ID |
Analyze ID |
Gene/Complex |
Systematic Name/Complex Accession |
Qualifier |
Gene Ontology Term ID |
Gene Ontology Term |
Aspect |
Annotation Extension |
Evidence |
Method |
Source |
Assigned On |
Reference |
Phenotype Annotations
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| Evidence ID |
Analyze ID |
Gene |
Gene Systematic Name |
Phenotype |
Experiment Type |
Experiment Type Category |
Mutant Information |
Strain Background |
Chemical |
Details |
Reference |
Disease Annotations
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| Evidence ID |
Analyze ID |
Gene |
Gene Systematic Name |
Disease Ontology Term |
Disease Ontology Term ID |
Qualifier |
Evidence |
Method |
Source |
Assigned On |
|
Reference |
Regulation Annotations
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| Evidence ID |
Analyze ID |
Regulator |
Regulator Systematic Name |
Target |
Target Systematic Name |
Direction |
Regulation of |
Happens During |
Regulator Type |
Direction |
Regulation Of |
Happens During |
Method |
Evidence |
Strain Background |
Reference |
Post-translational Modifications
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Site |
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Modification |
Modifier |
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Genetic Interactions
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| Evidence ID |
Analyze ID |
|
Interactor |
Interactor Systematic Name |
Interactor |
Interactor Systematic Name |
Allele |
Assay |
Annotation |
Action |
Phenotype |
SGA score |
P-value |
Source |
Reference |
Note |
Physical Interactions
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| Interactor | Interactor | Assay | Annotation | Action | Modification |
|---|
| CTK1 | CTK2 | Affinity Capture-MS | manually curated | Bait-Hit | No Modification |
| CTK1 | CTK3 | Affinity Capture-MS | manually curated | Bait-Hit | No Modification |
| CTK1 | RPT6 | Affinity Capture-Western | manually curated | Bait-Hit | No Modification |
| HPR1 | MFT1 | Affinity Capture-MS | manually curated | Bait-Hit | No Modification |
| HPR1 | THO2 | Affinity Capture-MS | manually curated | Bait-Hit | No Modification |
| HPR1 | RPT6 | Affinity Capture-Western | manually curated | Bait-Hit | No Modification |
| HPR1 | STO1 | Affinity Capture-Western | manually curated | Bait-Hit | No Modification |
| MTR2 | MEX67 | Affinity Capture-MS | manually curated | Hit-Bait | No Modification |
| NPL3 | STO1 | Affinity Capture-Western | manually curated | Bait-Hit | No Modification |
| RPB3 | RPO21 | Affinity Capture-MS | manually curated | Hit-Bait | No Modification |
Functional Complementation Annotations
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| Complement ID |
Locus ID |
Gene |
Species |
Gene ID |
Strain background |
Direction |
Details |
Source |
Reference |