Literature Help
TSC3 / YBR058C-A Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Hwang S, et al. (2025) Sphingolipid synthesis maintains nuclear membrane integrity and genome stability during cell division. J Cell Biol 224(8) PMID:40608049
- Körner C, et al. (2024) The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins. Cell Rep 43(8):114627 PMID:39167489
- Schäfer JH, et al. (2023) Structure of the ceramide-bound SPOTS complex. Nat Commun 14(1):6196 PMID:37794019
- Matos GS, et al. (2021) Regulation of sphingolipid synthesis by the G1/S transcription factor Swi4. Biochim Biophys Acta Mol Cell Biol Lipids 1866(9):158983 PMID:34062255
- Han G, et al. (2019) The ORMs interact with transmembrane domain 1 of Lcb1 and regulate serine palmitoyltransferase oligomerization, activity and localization. Biochim Biophys Acta Mol Cell Biol Lipids 1864(3):245-259 PMID:30529276
- Hwang S, et al. (2019) Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells. Cell Rep 29(8):2473-2488.e5 PMID:31747614
- Schmidt O, et al. (2019) Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism. EMBO J 38(15):e101433 PMID:31368600
- Ren J, et al. (2018) Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway. J Lipid Res 59(11):2126-2139 PMID:30154231
- Chauhan N, et al. (2016) Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1. J Biol Chem 291(5):2524-34 PMID:26634277
- Yofe I, et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods 13(4):371-378 PMID:26928762
- Voynova NS, et al. (2015) Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated. Eukaryot Cell 14(12):1203-16 PMID:26432633
- Gururaj C, et al. (2013) Orm proteins integrate multiple signals to maintain sphingolipid homeostasis. J Biol Chem 288(28):20453-63 PMID:23737533
- Lester RL, et al. (2013) Iron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase. Biochim Biophys Acta 1831(4):726-36 PMID:23286903
- Breslow DK, et al. (2010) Orm family proteins mediate sphingolipid homeostasis. Nature 463(7284):1048-53 PMID:20182505
- Han G, et al. (2009) Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities. Proc Natl Acad Sci U S A 106(20):8186-91 PMID:19416851
- Kastenmayer JP, et al. (2006) Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae. Genome Res 16(3):365-73 PMID:16510898
- Monaghan E, et al. (2002) Mutations in the Lcb2p subunit of serine palmitoyltransferase eliminate the requirement for the TSC3 gene in Saccharomyces cerevisiae. Yeast 19(8):659-70 PMID:12185836
- Gable K, et al. (2000) Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. J Biol Chem 275(11):7597-603 PMID:10713067
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
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Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Castells-Ballester J, et al. (2018) Monitoring Protein Dynamics in Protein O-Mannosyltransferase Mutants In Vivo by Tandem Fluorescent Protein Timers. Molecules 23(10) PMID:30322079
- Toume M and Tani M (2016) Yeast lacking the amphiphysin family protein Rvs167 is sensitive to disruptions in sphingolipid levels. FEBS J 283(15):2911-28 PMID:27312128
- Harmon JM, et al. (2013) Topological and functional characterization of the ssSPTs, small activating subunits of serine palmitoyltransferase. J Biol Chem 288(14):10144-10153 PMID:23426370
- Montefusco DJ, et al. (2012) Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability. J Biol Chem 287(12):9280-9 PMID:22277656
- Finnigan GC, et al. (2011) A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae. Genetics 187(3):771-83 PMID:21196517
- Kavun Ozbayraktar FB and Ulgen KO (2011) Stoichiometric network reconstruction and analysis of yeast sphingolipid metabolism incorporating different states of hydroxylation. Biosystems 104(1):63-75 PMID:21215790
- Guan XL, et al. (2010) Yeast lipid analysis and quantification by mass spectrometry. Methods Enzymol 470:369-91 PMID:20946818
- Teixeira MC, et al. (2010) Identification of genes required for maximal tolerance to high-glucose concentrations, as those present in industrial alcoholic fermentation media, through a chemogenomics approach. OMICS 14(2):201-10 PMID:20210661
- Garbarino J, et al. (2009) Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death. J Biol Chem 284(45):30994-1005 PMID:19690167
- Lorente-Rodríguez A, et al. (2009) Multicopy suppressor analysis of thermosensitive YIP1 alleles implicates GOT1 in transport from the ER. J Cell Sci 122(Pt 10):1540-50 PMID:19383723
- Cowart LA and Hannun YA (2007) Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis. J Biol Chem 282(16):12330-40 PMID:17322298
- White MA, et al. (2007) Characteristics affecting expression and solubilization of yeast membrane proteins. J Mol Biol 365(3):621-36 PMID:17078969
- Gaigg B, et al. (2005) Synthesis of sphingolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane ATPase to the cell surface of yeast. J Biol Chem 280(23):22515-22 PMID:15817474
- Zhang CT and Wang J (2000) Recognition of protein coding genes in the yeast genome at better than 95% accuracy based on the Z curve. Nucleic Acids Res 28(14):2804-14 PMID:10908339
- Beeler T, et al. (1998) The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant. J Biol Chem 273(46):30688-94 PMID:9804843
Reviews
No reviews curated.
Download References (.nbib)
- Mughram MHA, et al. (2024) Three kingdoms and one ceramide to rule them all. A comparison of the structural basis of ceramide-dependent regulation of sphingolipid biosynthesis in animals, plants, and fungi. Adv Biol Regul 91:101010 PMID:38135565
- Tani M (2024) Biological Importance of Complex Sphingolipids and Their Structural Diversity in Budding Yeast Saccharomyces cerevisiae. Int J Mol Sci 25(22) PMID:39596489
- Schlarmann P, et al. (2021) Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis. Membranes (Basel) 11(12) PMID:34940472
- Davis D, et al. (2018) Orm/ORMDL proteins: Gate guardians and master regulators. Adv Biol Regul 70:3-18 PMID:30193828
- Marquês JT, et al. (2018) Sphingolipid hydroxylation in mammals, yeast and plants - An integrated view. Prog Lipid Res 71:18-42 PMID:29746894
- Mitrofanova D, et al. (2018) Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae. Front Biosci (Landmark Ed) 23(6):1166-1194 PMID:28930594
- Megyeri M, et al. (2016) Making Sense of the Yeast Sphingolipid Pathway. J Mol Biol 428(24 Pt A):4765-4775 PMID:27664439
- Teixeira V and Costa V (2016) Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism. Prog Lipid Res 61:109-33 PMID:26703187
- Klug L and Daum G (2014) Yeast lipid metabolism at a glance. FEMS Yeast Res 14(3):369-88 PMID:24520995
- Montefusco DJ, et al. (2014) The yeast sphingolipid signaling landscape. Chem Phys Lipids 177:26-40 PMID:24220500
- Rego A, et al. (2014) The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids. FEMS Yeast Res 14(1):160-78 PMID:24103214
- Breslow DK (2013) Sphingolipid homeostasis in the endoplasmic reticulum and beyond. Cold Spring Harb Perspect Biol 5(4):a013326 PMID:23545423
- Epstein S and Riezman H (2013) Sphingolipid signaling in yeast: potential implications for understanding disease. Front Biosci (Elite Ed) 5(1):97-108 PMID:23276973
- Koeller CM and Heise N (2011) The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas Disease. Enzyme Res 2011:648159 PMID:21603271
- Walther TC (2010) Keeping sphingolipid levels nORMal. Proc Natl Acad Sci U S A 107(13):5701-2 PMID:20304791
- Ozbayraktar FB and Ulgen KO (2009) Molecular facets of sphingolipids: mediators of diseases. Biotechnol J 4(7):1028-41 PMID:19579220
- Dickson RC (2008) Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast. J Lipid Res 49(5):909-21 PMID:18296751
- Cowart LA and Obeid LM (2007) Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function. Biochim Biophys Acta 1771(3):421-31 PMID:16997623
- Kihara A, et al. (2007) Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Prog Lipid Res 46(2):126-44 PMID:17449104
- Dickson RC, et al. (2006) Functions and metabolism of sphingolipids in Saccharomyces cerevisiae. Prog Lipid Res 45(6):447-65 PMID:16730802
- Riezman H (2006) Organization and functions of sphingolipid biosynthesis in yeast. Biochem Soc Trans 34(Pt 3):367-9 PMID:16709163
- Thevissen K, et al. (2005) Fungal sphingolipids as targets for the development of selective antifungal therapeutics. Curr Drug Targets 6(8):923-8 PMID:16375675
- Warnecke D and Heinz E (2003) Recently discovered functions of glucosylceramides in plants and fungi. Cell Mol Life Sci 60(5):919-41 PMID:12827281
- Funato K, et al. (2002) Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae. Biochemistry 41(51):15105-14 PMID:12484746
- Hannun YA, et al. (2001) Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry 40(16):4893-903 PMID:11305904
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Download References (.nbib)
- Yofe I, et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods 13(4):371-378 PMID:26928762
- Lester RL, et al. (2013) Iron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase. Biochim Biophys Acta 1831(4):726-36 PMID:23286903
- Breslow DK, et al. (2010) Orm family proteins mediate sphingolipid homeostasis. Nature 463(7284):1048-53 PMID:20182505
- Gable K, et al. (2000) Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. J Biol Chem 275(11):7597-603 PMID:10713067
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Download References (.nbib)
- Hwang S, et al. (2025) Sphingolipid synthesis maintains nuclear membrane integrity and genome stability during cell division. J Cell Biol 224(8) PMID:40608049
- Matos GS, et al. (2021) Regulation of sphingolipid synthesis by the G1/S transcription factor Swi4. Biochim Biophys Acta Mol Cell Biol Lipids 1866(9):158983 PMID:34062255
- Lester RL, et al. (2013) Iron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase. Biochim Biophys Acta 1831(4):726-36 PMID:23286903
- Kastenmayer JP, et al. (2006) Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae. Genome Res 16(3):365-73 PMID:16510898
- Gable K, et al. (2000) Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. J Biol Chem 275(11):7597-603 PMID:10713067
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- Körner C, et al. (2024) The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins. Cell Rep 43(8):114627 PMID:39167489
- Xie T, et al. (2024) Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide. Cell Rep 43(2):113717 PMID:38285738
- Caydasi AK, et al. (2023) SWR1 chromatin remodeling complex prevents mitotic slippage during spindle position checkpoint arrest. Mol Biol Cell 34(2):ar11 PMID:36542480
- Esch BM, et al. (2023) Identification of distinct active pools of yeast serine palmitoyltransferase in sub-compartments of the ER. J Cell Sci 136(23) PMID:37982431
- Kolhe JA, et al. (2023) The Hsp90 molecular chaperone governs client proteins by targeting intrinsically disordered regions. Mol Cell 83(12):2035-2044.e7 PMID:37295430
- Michaelis AC, et al. (2023) The social and structural architecture of the yeast protein interactome. Nature 624(7990):192-200 PMID:37968396
- Schäfer JH, et al. (2023) Structure of the ceramide-bound SPOTS complex. Nat Commun 14(1):6196 PMID:37794019
- Backes S, et al. (2021) The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress. Cell Rep 35(1):108936 PMID:33826901
- Sanders E, et al. (2020) Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1. G3 (Bethesda) 10(12):4359-4368 PMID:33115720
- Wang Y, et al. (2020) Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase. J Cell Biol 219(5) PMID:32303746
- Han G, et al. (2019) The ORMs interact with transmembrane domain 1 of Lcb1 and regulate serine palmitoyltransferase oligomerization, activity and localization. Biochim Biophys Acta Mol Cell Biol Lipids 1864(3):245-259 PMID:30529276
- Kuzmin E, et al. (2018) Systematic analysis of complex genetic interactions. Science 360(6386) PMID:29674565
- Mount HO, et al. (2018) Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs. PLoS Genet 14(4):e1007319 PMID:29702647
- Ren J, et al. (2018) Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway. J Lipid Res 59(11):2126-2139 PMID:30154231
- Chauhan N, et al. (2016) Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1. J Biol Chem 291(5):2524-34 PMID:26634277
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- De Block J, et al. (2015) Yeast Pmp3p has an important role in plasma membrane organization. J Cell Sci 128(19):3646-59 PMID:26303201
- Lapointe CP, et al. (2015) Protein-RNA networks revealed through covalent RNA marks. Nat Methods 12(12):1163-70 PMID:26524240
- Gururaj C, et al. (2013) Orm proteins integrate multiple signals to maintain sphingolipid homeostasis. J Biol Chem 288(28):20453-63 PMID:23737533
- van Pel DM, et al. (2013) Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. G3 (Bethesda) 3(2):273-82 PMID:23390603
- Finnigan GC, et al. (2011) A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae. Genetics 187(3):771-83 PMID:21196517
- Stirling PC, et al. (2011) The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genet 7(4):e1002057 PMID:21552543
- Breslow DK, et al. (2010) Orm family proteins mediate sphingolipid homeostasis. Nature 463(7284):1048-53 PMID:20182505
- Batisse J, et al. (2009) Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. J Biol Chem 284(50):34911-7 PMID:19840948
- Garbarino J, et al. (2009) Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death. J Biol Chem 284(45):30994-1005 PMID:19690167
- Lorente-Rodríguez A, et al. (2009) Multicopy suppressor analysis of thermosensitive YIP1 alleles implicates GOT1 in transport from the ER. J Cell Sci 122(Pt 10):1540-50 PMID:19383723
- Schuldiner M, et al. (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19 PMID:16269340
- Monaghan E, et al. (2002) Mutations in the Lcb2p subunit of serine palmitoyltransferase eliminate the requirement for the TSC3 gene in Saccharomyces cerevisiae. Yeast 19(8):659-70 PMID:12185836
- Gable K, et al. (2000) Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. J Biol Chem 275(11):7597-603 PMID:10713067
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
Download References (.nbib)
- Mota MN, et al. (2024) Shared and more specific genetic determinants and pathways underlying yeast tolerance to acetic, butyric, and octanoic acids. Microb Cell Fact 23(1):71 PMID:38419072
- Grosjean N, et al. (2023) Yeast Deletomics to Uncover Gadolinium Toxicity Targets and Resistance Mechanisms. Microorganisms 11(8) PMID:37630673
- Forster DT, et al. (2022) BIONIC: biological network integration using convolutions. Nat Methods 19(10):1250-1261 PMID:36192463
- Nicastro R, et al. (2021) Indole-3-acetic acid is a physiological inhibitor of TORC1 in yeast. PLoS Genet 17(3):e1009414 PMID:33690632
- Johnston NR, et al. (2020) Genome-Wide Identification of Genes Involved in General Acid Stress and Fluoride Toxicity in Saccharomyces cerevisiae. Front Microbiol 11:1410 PMID:32670247
- Grosjean N, et al. (2018) Global Deletome Profile of Saccharomyces cerevisiae Exposed to the Technology-Critical Element Yttrium. Front Microbiol 9:2005 PMID:30233513
- Neumüller RA, et al. (2013) Conserved regulators of nucleolar size revealed by global phenotypic analyses. Sci Signal 6(289):ra70 PMID:23962978
- van Pel DM, et al. (2013) Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. G3 (Bethesda) 3(2):273-82 PMID:23390603
- Pimentel C, et al. (2012) The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability. PLoS One 7(5):e37434 PMID:22616008
- Venters BJ, et al. (2011) A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell 41(4):480-92 PMID:21329885
- Teixeira MC, et al. (2010) Identification of genes required for maximal tolerance to high-glucose concentrations, as those present in industrial alcoholic fermentation media, through a chemogenomics approach. OMICS 14(2):201-10 PMID:20210661
- Garbarino J, et al. (2009) Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death. J Biol Chem 284(45):30994-1005 PMID:19690167
- Sinha H, et al. (2008) Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast. Genetics 180(3):1661-70 PMID:18780730
- Kastenmayer JP, et al. (2006) Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae. Genome Res 16(3):365-73 PMID:16510898
- Kawahata M, et al. (2006) Yeast genes involved in response to lactic acid and acetic acid: acidic conditions caused by the organic acids in Saccharomyces cerevisiae cultures induce expression of intracellular metal metabolism genes regulated by Aft1p. FEMS Yeast Res 6(6):924-36 PMID:16911514