Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
40 entries for 11 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| chromosome/plasmid maintenance: decreased | systematic mutation set | overexpression | Other | Assay: a-like faker (ALF) assay Details: dosage chromosome instability (dCIN) involving chromosome loss, rearrangement and/or gene conversion events | Duffy S, et al. (2016) PMID:27551064 | |
| chromosome/plasmid maintenance: decreased | classical genetics | null Allele: fpr4-Δ | Other | Details: reduction in genome stability at the rDNA locus, based on an rDNA::URA3 reporter gene; indicative of a role in the regulation of rDNA stability | Gauthier CM, et al. (2024) PMID:38058218 | |
| chromosome/plasmid maintenance: decreased | classical genetics | null Allele: fpr4-Δ | S288C | Details: expanded rDNA array; indicative of a role in regulating rDNA copy number; rescued by expression of the FKBP prolyl isomerase domain (fpr4-ΔNPM) | Gauthier CM, et al. (2024) PMID:38058218 | |
| chronological lifespan: increased | competitive growth competitive survival of stationary phase co-cultures | null Allele: fpr4-Δ | S288C | Garay E, et al. (2014) PMID:24586198 | ||
| competitive fitness: normal | competitive growth fitness profiling using complete deletion alleles | null Allele: fpr4-Δ | S288C | Media: minimal medium Details: Relative fitness score: 1 | Breslow DK, et al. (2008) PMID:18622397 | |
| haploinsufficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: fpr4-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: -0.0023 | Pir P, et al. (2012) PMID:22244311 | |
| protein activity: increased Reporter: metal reductase | systematic mutation set cell surface metal reductase activity quantified using BPS and scoring colonies for red color | null Allele: fpr4-Δ | S288C | Dong K, et al. (2013) PMID:23959798 | ||
| resistance to chemicals: increased | systematic mutation set | null Allele: fpr4-Δ | S288C | 180 μM chlorpromazine | Details: increased tolerance to treatment with chlorpromazine at a concentration of 180 μM, just below the MIC99 of 210 μM on plates | Caldara M, et al. (2017) PMID:28087837 |
| resistance to chemicals: increased | classical genetics | null Allele: fpr4-Δ | S288C | 100 μM promazine | Details: increased tolerance to treatment with promazine at 100 μM, the MIC99 in liquid media | Caldara M, et al. (2017) PMID:28087837 |
| resistance to chemicals: increased | classical genetics | null Allele: fpr4-Δ | S288C | 30 μM chlorpromazine | Details: increased tolerance to treatment with chlorpromazine at 30 μM, the MIC99 in liquid media | Caldara M, et al. (2017) PMID:28087837 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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