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XRN1 / YGL173C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Aliases
KEM1 11 , DST2 12 , RAR5 13 , SEP1 14 , SKI1 15
Protein Product
chromatin-binding exonuclease XRN1
Feature Type
ORF , Verified
Description
Evolutionarily-conserved 5'-3' exonuclease; component of cytoplasmic processing (P) bodies involved in mRNA decay; enters the nucleus and positively regulates transcription initiation and elongation; involved in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, telomere maintenance, and turnover of tRNA introns; negative regulator of autophagy; activated by the scavenger decapping enzyme Dcs1p; expression regulated by Ash1p in rich conditions 1 2 3 4 5 6 7 8 9 10

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