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NPL3 / YDR432W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

NAB1 11 , MTR13 12 , MTS1 13 , NOP3 14
Protein Product
mRNA-binding protein NPL3
Feature Type
ORF , Verified
RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; represses translation initiation by binding eIF4G; required for pre-mRNA splicing; interacts with E3 ubiquitin ligase Bre1p, linking histone ubiquitination to mRNA processing; may have role in telomere maintenance; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in cytoplasm; protein abundance increases in response to DNA replication stress 2 3 4 5 6 7 8 9 10