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SAC6 / YDR129C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Aliases
ABP67 11
Protein Product
fimbrin
Feature Type
ORF , Verified
Description
Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant 3 4 5 6 8 9 10

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