Phenotype Help

PGM1 / YKL127W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutants grow slowly, are sensitive to Calcofluor White, have some resistance to K2 killer toxin, grow well in glycerol or ethanol but not on synthetic complete; heterozygous diploid null displays chromosome instability

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

12 entries for 9 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chromosome/plasmid maintenance: decreased
heterozygous diploid, systematic mutation setnull
Allele: pgm1-Δ
S288CAssay: diploid bimater (BiM) assay
Details: haploinsufficiency results in chromosome instability (CIN); scored >= 2 standard deviations above the mean
Choy JS, et al. (2013) PMID:23825022
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: pgm1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.999
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
systematic mutation setnull
Allele: pgm1-Δ
S288CMedia: synthetic complete medium, SC
Qian W, et al. (2012) PMID:23103169
competitive fitness: increased
systematic mutation setnull
Allele: pgm1-Δ
S288C ethanolQian W, et al. (2012) PMID:23103169
competitive fitness: increased
systematic mutation setnull
Allele: pgm1-Δ
S288CMedia: glycerol medium, YPG
Qian W, et al. (2012) PMID:23103169
killer toxin resistance: increased
systematic mutation setnull
Allele: pgm1-Δ
S288CDetails: K2
Servienė E, et al. (2012) PMID:23227207
resistance to chemicals: decreased
classical geneticsnull
Allele: pgm1-Δ
Other0.5 mg/ml Calcofluor WhiteDaran JM, et al. (1997) PMID:9252577
resistance to chemicals: decreased
homozygous diploid, competitive growthnull
Allele: pgm1-Δ
S288C400 uM actinomycin DBrown JA, et al. (2006) PMID:16738548
starvation resistance: decreased
heterozygous diploid, competitive growth

pooled mutant strains were subjected to low nutrient stress, then dead cells were separated and their mutations identified

null
Allele: pgm1-Δ
S288CDavey HM, et al. (2012) PMID:22356628
toxin resistance: increased
systematic mutation setoverexpressionS288CDetails: TDP-43; human RNA-binding protein that forms inclusions and aggregates in ALS disease models
Kim HJ, et al. (2014) PMID:24336168
Showing 1 to 10 of 12 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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