YPK1 / YKL126W Homology
- Standard Name
- YPK1 1
- Systematic Name
- YKL126W
- SGD ID
- SGD:S000001609
- Aliases
- SLI2 2
- Feature Type
- ORF , Verified
- Description
- S/T protein kinase; required for PM lipid and protein homeostasis; involved in sphingolipid-mediated and cell integrity signaling pathways and endocytosis; phosphorylates and downregulates Fpk1p; phosphorylates and inactivates Orm1p/2p when sphingolipid synthesis is compromised; role in TORC1/2-dependent Rps6a/b phosphorylation; phosphorylated and activated by TORC2 and by Pkh1/2p in the presence of phytosphingosine; human homolog SGK1 complements the null and inviability of a ypk1 ypk2 mutant 2 3 4 5 6 7 8 9 10 11 12 13 14
- Name Description
- Yeast Protein Kinase 1
- Paralog
- YPK2 9
- Comparative Info
-
Homologs
Homology calls are sourced from the Alliance of Genome Resources. Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). The homolog inferences from the different methods have been integrated using the DRSC Integrative Ortholog Prediction Tool (DIOPT), which integrates a number of existing methods including those used by the Alliance: Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, and ZFIN.
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| HOMOLOG ID | Species | Gene ID | Gene name | Source |
|---|
Functional Complementation
Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD).
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
|---|
Fungal Homologs
Fungal Homology calls are sourced from YeastMine, which compiles fungal homology calls from FungiDB, CGD, Panther, PomBase, TreeFam, HomoloGene, and SGD.
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| HOMOLOG ID | Species | Gene ID | Gene name | Description | Source |
|---|
External Identifiers
List of external identifiers for the protein from various database sources.
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| Alias ID | External ID | Source |
|---|
Resources
Homologs
AGD | AnalogYeast | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | YGOB | YOGY
Protein Databases
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
Localization
CYCLoPs | dHITS | LoQAtE | Organelle DB | YeastGFP | YeastRC Public Images | YeastRGB | YPL+
Post-translational Modifications
CoSMoS.c. | PhosphoGRID | PhosphoPep
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi