Sequence Help

PRP8 / YHR165C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

USA2 8 , DBF3 9 10 , DNA39 10 11 , RNA8 12 , SLT21 13
Protein Product
U4/U6-U5 snRNP complex subunit PRP8
Feature Type
ORF , Verified
Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer 2 3 4 5 6 7