Phenotype Help

PRP8 / YHR165C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Essential gene; heterozygous null haploinsufficiency results in chromosome instability; reduced function and conditional alleles show increased heat sensitivity, cold sensitivity, broad splicing defect

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

15 entries for 6 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chromosome/plasmid maintenance: decreased
heterozygous diploid, systematic mutation setnull
Allele: prp8-Δ
S288CAssay: diploid bimater (BiM) assay
Details: haploinsufficiency results in chromosome instability (CIN); scored >= 2 standard deviations above the mean
Choy JS, et al. (2013) PMID:23825022
cold sensitivity: increased
classical genetics reduction of function
Allele: prp8-R1753K
OtherTemperature: reduced temperature, 16 °C
van der Feltz C, et al. (2021) PMID:33547186
cold sensitivity: increased
classical genetics reduction of function
Allele: prp8-E1960K
OtherTemperature: reduced temperature, 23 °C
van der Feltz C, et al. (2021) PMID:33547186
heat sensitivity: increased
classical geneticsconditionalOtherTemperature: elevated temperature, 36 °C
Hartwell LH, et al. (1970) PMID:5488085
heat sensitivity: increased
classical genetics reduction of function
Allele: prp8-R1753K
OtherTemperature: elevated temperature, 37 °C
van der Feltz C, et al. (2021) PMID:33547186
heat sensitivity: increased
classical geneticsconditional
Allele: prp8-1
OtherTemperature: elevated temperature, 33 °C
Pleiss JA, et al. (2007) PMID:17388687
heat sensitivity: increased
classical geneticsreduction of function
Allele: prp8-H2387P

corresponds to human prp8-H2309P implicated in retinitis pigmentosa

OtherTemperature: elevated temperature, 37 °C
Mayerle M and Guthrie C (2016) PMID:26968627
inviable
classical geneticsnull
Allele: prp8-Δ
OtherJackson SP, et al. (1988) PMID:2835658
RNA accumulation: increased
Reporter: actin pre-mRNA
classical geneticsconditional
Allele: prp8-(rna8-1)
OtherTemperature: elevated temperature, 36 °C
Jackson SP, et al. (1988) PMID:2835658
RNA accumulation: increased
Reporter: pre-mRNA
classical geneticsreduction of function
Allele: prp8-S2197F

corresponds to human prp8-S2117F implicated in retinitis pigmentosa

OtherDetails: indicative of broad splicing defect
Mayerle M and Guthrie C (2016) PMID:26968627
Showing 1 to 10 of 15 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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