Literature Help
EMC1 / YCL045C Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Bai L, et al. (2020) Structure of the ER membrane complex, a transmembrane-domain insertase. Nature 584(7821):475-478 PMID:32494008
- Miller-Vedam LE, et al. (2020) Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife 9 PMID:33236988
- Kudze T, et al. (2018) Evidence for interaction between Hsp90 and the ER membrane complex. Cell Stress Chaperones 23(5):1101-1115 PMID:29808299
- Yofe I, et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods 13(4):371-378 PMID:26928762
- Lahiri S, et al. (2014) A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. PLoS Biol 12(10):e1001969 PMID:25313861
- Novo M, et al. (2013) Genome-wide study of the adaptation of Saccharomyces cerevisiae to the early stages of wine fermentation. PLoS One 8(9):e74086 PMID:24040173
- Richard M, et al. (2013) Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Proc Natl Acad Sci U S A 110(11):E1055-63 PMID:23431131
- Jonikas MC, et al. (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7 PMID:19325107
- Hertveldt K, et al. (2003) Identification of Gal80p-interacting proteins by Saccharomyces cerevisiae whole genome phage display. Gene 307:141-9 PMID:12706896
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
Reset
Click on a gene or a paper to go to its specific page within SGD. Drag any of the gene or paper objects around
within the visualization for easier viewing and click “Reset” to automatically redraw the diagram.
Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Fenech EJ, et al. (2023) A toolbox for systematic discovery of stable and transient protein interactors in baker's yeast. Mol Syst Biol 19(2):e11084 PMID:36651308
- Schulze Y, et al. (2023) Chemical-genomic profiling identifies genes that protect yeast from aluminium, gallium, and indium toxicity. Metallomics 15(6) PMID:37193668
- Huang M, et al. (2018) Engineering the protein secretory pathway of Saccharomyces cerevisiae enables improved protein production. Proc Natl Acad Sci U S A 115(47):E11025-E11032 PMID:30397111
- Shurtleff MJ, et al. (2018) The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. Elife 7 PMID:29809151
- Michaud M, et al. (2017) Glycerolipid synthesis and lipid trafficking in plant mitochondria. FEBS J 284(3):376-390 PMID:27406373
- Wideman JG (2015) The ubiquitous and ancient ER membrane protein complex (EMC): tether or not? F1000Res 4:624 PMID:26512320
- Vincent M, et al. (2014) Surveying the floodgates: estimating protein flux into the endoplasmic reticulum lumen in Saccharomyces cerevisiae. Front Physiol 5:444 PMID:25431559
- Breidenbach MA, et al. (2012) Mapping yeast N-glycosites with isotopically recoded glycans. Mol Cell Proteomics 11(6):M111.015339 PMID:22261724
- Louie RJ, et al. (2012) A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis. Genome Med 4(12):103 PMID:23270647
- Bircham PW, et al. (2011) Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Mol Biosyst 7(9):2589-98 PMID:21731954
- Zou J, et al. (2009) Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae. Mol Biol Cell 20(14):3239-50 PMID:19458192
- Stagoj MN, et al. (2005) Fluorescence based assay of GAL system in yeast Saccharomyces cerevisiae. FEMS Microbiol Lett 244(1):105-10 PMID:15727828
- Bond U, et al. (2004) Aneuploidy and copy number breakpoints in the genome of lager yeasts mapped by microarray hybridisation. Curr Genet 45(6):360-70 PMID:15103502
- Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 PMID:14562095
- Koonin EV, et al. (1994) Yeast chromosome III: new gene functions. EMBO J 13(3):493-503 PMID:8313894
- Scherens B, et al. (1992) The complete sequence of a 9,543 bp segment on the left arm of chromosome III reveals five open reading frames including glucokinase and the protein disulfide isomerase. Yeast 8(7):577-85 PMID:1523890
Reviews
No reviews curated.
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Download References (.nbib)
- Bai L, et al. (2020) Structure of the ER membrane complex, a transmembrane-domain insertase. Nature 584(7821):475-478 PMID:32494008
- Zhao YY, et al. (2020) Identification of the Genetic Requirements for Zinc Tolerance and Toxicity in Saccharomyces cerevisiae. G3 (Bethesda) 10(2):479-488 PMID:31836620
- Osterberg M, et al. (2006) Phenotypic effects of membrane protein overexpression in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 103(30):11148-53 PMID:16847257
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- Bertgen L, et al. (2024) Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress. Cell Rep 43(4):114018 PMID:38551959
- Kofler L, et al. (2024) The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation. Nat Commun 15(1):7511 PMID:39209816
- O'Brien MJ and Ansari A (2024) Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle. Biochim Biophys Acta Proteins Proteom 1872(1):140968 PMID:37863410
- Carey SB, et al. (2023) A synthetic genetic array screen for interactions with the RNA helicase DED1 during cell stress in budding yeast. G3 (Bethesda) 13(1) PMID:36409020
- Joshua IM, et al. (2023) A Protein-Protein Interaction Analysis Suggests a Wide Range of New Functions for the p21-Activated Kinase (PAK) Ste20. Int J Mol Sci 24(21) PMID:37958899
- Kolhe JA, et al. (2023) The Hsp90 molecular chaperone governs client proteins by targeting intrinsically disordered regions. Mol Cell 83(12):2035-2044.e7 PMID:37295430
- Meyer L, et al. (2023) eIF2A represses cell wall biogenesis gene expression in Saccharomyces cerevisiae. PLoS One 18(11):e0293228 PMID:38011112
- Michaelis AC, et al. (2023) The social and structural architecture of the yeast protein interactome. Nature 624(7990):192-200 PMID:37968396
- Gavade JN, et al. (2022) Identification of 14-3-3 proteins, Polo kinase, and RNA-binding protein Pes4 as key regulators of meiotic commitment in budding yeast. Curr Biol 32(7):1534-1547.e9 PMID:35240051
- Lu PYT, et al. (2022) A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans. Genetics 222(3) PMID:36066422
- Decourty L, et al. (2021) Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast. Nucleic Acids Res 49(15):8535-8555 PMID:34358317
- Bai L, et al. (2020) Structure of the ER membrane complex, a transmembrane-domain insertase. Nature 584(7821):475-478 PMID:32494008
- Pereira F, et al. (2019) Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation. PLoS One 14(1):e0211180 PMID:30682149
- Jungfleisch J, et al. (2017) A novel translational control mechanism involving RNA structures within coding sequences. Genome Res 27(1):95-106 PMID:27821408
- Aviram N, et al. (2016) The SND proteins constitute an alternative targeting route to the endoplasmic reticulum. Nature 540(7631):134-138 PMID:27905431
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Shin JJ, et al. (2016) Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets. Dis Model Mech 9(9):1039-49 PMID:27519690
- Steunou AL, et al. (2016) Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome. Mol Cell Biol 36(22):2768-2781 PMID:27550811
- Lapointe CP, et al. (2015) Protein-RNA networks revealed through covalent RNA marks. Nat Methods 12(12):1163-70 PMID:26524240
- Porter DF, et al. (2015) Target selection by natural and redesigned PUF proteins. Proc Natl Acad Sci U S A 112(52):15868-73 PMID:26668354
- Lahiri S, et al. (2014) A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. PLoS Biol 12(10):e1001969 PMID:25313861
- Mitchell SF, et al. (2013) Global analysis of yeast mRNPs. Nat Struct Mol Biol 20(1):127-33 PMID:23222640
- Surma MA, et al. (2013) A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. Mol Cell 51(4):519-30 PMID:23891562
- Louie RJ, et al. (2012) A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis. Genome Med 4(12):103 PMID:23270647
- Manford AG, et al. (2012) ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology. Dev Cell 23(6):1129-40 PMID:23237950
- Moehle EA, et al. (2012) The yeast SR-like protein Npl3 links chromatin modification to mRNA processing. PLoS Genet 8(11):e1003101 PMID:23209445
- Bircham PW, et al. (2011) Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Mol Biosyst 7(9):2589-98 PMID:21731954
- Finnigan GC, et al. (2011) A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae. Genetics 187(3):771-83 PMID:21196517
- Hoppins S, et al. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2):323-40 PMID:21987634
- Costanzo M, et al. (2010) The genetic landscape of a cell. Science 327(5964):425-31 PMID:20093466
- Vembar SS, et al. (2010) J domain co-chaperone specificity defines the role of BiP during protein translocation. J Biol Chem 285(29):22484-94 PMID:20430885
- Batisse J, et al. (2009) Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. J Biol Chem 284(50):34911-7 PMID:19840948
- Jonikas MC, et al. (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7 PMID:19325107
- Tonikian R, et al. (2009) Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins. PLoS Biol 7(10):e1000218 PMID:19841731
- Zou J, et al. (2009) Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae. Mol Biol Cell 20(14):3239-50 PMID:19458192
- Krogan NJ, et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature 440(7084):637-43 PMID:16554755
- Pan X, et al. (2006) A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell 124(5):1069-81 PMID:16487579
- Schuldiner M, et al. (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19 PMID:16269340
- Hertveldt K, et al. (2003) Identification of Gal80p-interacting proteins by Saccharomyces cerevisiae whole genome phage display. Gene 307:141-9 PMID:12706896
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
Download References (.nbib)
- Phua CZJ, et al. (2023) Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites, and pathways that regulate lifespan. Geroscience 45(4):2161-2178 PMID:37086368
- Schulze Y, et al. (2023) Chemical-genomic profiling identifies genes that protect yeast from aluminium, gallium, and indium toxicity. Metallomics 15(6) PMID:37193668
- Coey CT and Clark DJ (2022) A systematic genome-wide account of binding sites for the model transcription factor Gcn4. Genome Res 32(2):367-377 PMID:34916251
- Goh CJH, et al. (2022) Diethyl phthalate (DEP) perturbs nitrogen metabolism in Saccharomyces cerevisiae. Sci Rep 12(1):10237 PMID:35715465
- Liu HL, et al. (2021) Tryptophan plays an important role in yeast's tolerance to isobutanol. Biotechnol Biofuels 14(1):200 PMID:34645498
- Helsen J, et al. (2020) Gene Loss Predictably Drives Evolutionary Adaptation. Mol Biol Evol 37(10):2989-3002 PMID:32658971
- Molin M, et al. (2020) Protein kinase A controls yeast growth in visible light. BMC Biol 18(1):168 PMID:33198745
- Zhao YY, et al. (2020) Identification of the Genetic Requirements for Zinc Tolerance and Toxicity in Saccharomyces cerevisiae. G3 (Bethesda) 10(2):479-488 PMID:31836620
- Fröhlich F, et al. (2015) The GARP complex is required for cellular sphingolipid homeostasis. Elife 4 PMID:26357016
- Gaupel AC, et al. (2014) High throughput screening identifies modulators of histone deacetylase inhibitors. BMC Genomics 15(1):528 PMID:24968945
- Hoepfner D, et al. (2014) High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions. Microbiol Res 169(2-3):107-20 PMID:24360837
- Pereira FB, et al. (2014) Genome-wide screening of Saccharomyces cerevisiae genes required to foster tolerance towards industrial wheat straw hydrolysates. J Ind Microbiol Biotechnol 41(12):1753-61 PMID:25287021
- VanderSluis B, et al. (2014) Broad metabolic sensitivity profiling of a prototrophic yeast deletion collection. Genome Biol 15(4):R64 PMID:24721214
- Gaytán BD, et al. (2013) Functional profiling discovers the dieldrin organochlorinated pesticide affects leucine availability in yeast. Toxicol Sci 132(2):347-58 PMID:23358190
- Michaillat L and Mayer A (2013) Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiae. PLoS One 8(2):e54160 PMID:23383298
- Novo M, et al. (2013) Genome-wide study of the adaptation of Saccharomyces cerevisiae to the early stages of wine fermentation. PLoS One 8(9):e74086 PMID:24040173
- Samanfar B, et al. (2013) Large-scale investigation of oxygen response mutants in Saccharomyces cerevisiae. Mol Biosyst 9(6):1351-9 PMID:23467670
- Qian W, et al. (2012) The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep 2(5):1399-410 PMID:23103169
- Teng X, et al. (2011) Gene-dependent cell death in yeast. Cell Death Dis 2(8):e188 PMID:21814286
- Venters BJ, et al. (2011) A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell 41(4):480-92 PMID:21329885
- Villa-García MJ, et al. (2011) Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling. Mol Genet Genomics 285(2):125-49 PMID:21136082
- Yoshikawa K, et al. (2011) Comprehensive phenotypic analysis of single-gene deletion and overexpression strains of Saccharomyces cerevisiae. Yeast 28(5):349-61 PMID:21341307
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- Hu Z, et al. (2007) Genetic reconstruction of a functional transcriptional regulatory network. Nat Genet 39(5):683-7 PMID:17417638
- Lum PY, et al. (2004) Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell 116(1):121-37 PMID:14718172
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549