Reference: Eisenberg-Bord M, et al. (2016) A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites. Dev Cell 39(4):395-409

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Abstract


Membrane contact sites enable interorganelle communication by positioning organelles in close proximity using molecular "tethers." With a growing understanding of the importance of contact sites, the hunt for new contact sites and their tethers is in full swing. Determining just what is a tether has proven challenging. Here, we aim to delineate guidelines that define the prerequisites for categorizing a protein as a tether. Setting this gold standard now, while groups from different disciplines are beginning to explore membrane contact sites, will enable efficient cooperation in the growing field and help to realize a great collaborative opportunity to boost its development.

Reference Type
Journal Article | Review
Authors
Eisenberg-Bord M, Shai N, Schuldiner M, Bohnert M
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