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IRA1 / YBR140C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

GLC1 22 , PPD1 23
Protein Product
GTPase-activating protein IRA1
Feature Type
ORF , Verified
GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis 1 2 3 4 5 6
IRA2 5