Phenotype Help

TEF2 / YBR118W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene in reference strain S288C; null mutants are sensitive to TOR inhibitor rapamycin; heterozygous diploid null mutants are heat-tolerant, have unstable chromosomes, and are sensitive to various antibiotics; overexpression increases cell size, interferes with the cell cycle, slows growth, and disturbs the actin cytoskeleton

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

18 entries for 12 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
actin cytoskeleton morphology: abnormal
classical geneticsoverexpressionOtherDetails: actin is distributed along the length of buds rather than at the tips
Munshi R, et al. (2001) PMID:11290701
cell cycle progression: abnormal
large-scale surveyoverexpressionW303Details: greater than 3% shift in cells containing a 1C DNA content, indicative of a G1 phase arrest or delay
Stevenson LF, et al. (2001) PMID:11274415
cell size: increased
classical geneticsoverexpressionOtherDetails: cells are large and rounded
Munshi R, et al. (2001) PMID:11290701
chromosome/plasmid maintenance: decreased
heterozygous diploid, systematic mutation setnull
Allele: tef2-Δ
S288CAssay: diploid bimater (BiM) assay
Details: haploinsufficiency results in chromosome instability (CIN); scored >= 2 standard deviations above the mean
Choy JS, et al. (2013) PMID:23825022
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: tef2-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.944
Breslow DK, et al. (2008) PMID:18622397
haploinsufficient
heterozygous diploid, systematic mutation set null
Allele: tef2-Δ
S288COhnuki S and Ohya Y (2018) PMID:29768403
innate thermotolerance: increased
heterozygous diploid, systematic mutation setnull
Allele: tef2-Δ
S288CPhase: stationary phase
Treatment: heat shock, 50 °C
Details: resistance scale of 1 (least) to 4 (most) resistant: 3
Jarolim S, et al. (2013) PMID:24142923
resistance to chemicals: absent
classical genetics null
Allele: tef2-Δ
Other sirolimusCao S, et al. (2017) PMID:28911200
resistance to chemicals: absent
classical genetics reduction of function
Allele: tef2-G70S
Other sirolimusCao S, et al. (2017) PMID:28911200
resistance to chemicals: decreased
classical geneticsnull
Allele: tef2-Δ
CEN.PK40 ng/ml sirolimusDetails: sirolimus is rapamycin
Laxman S and Tu BP (2011) PMID:22043304
Showing 1 to 10 of 18 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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