ETR1 / YBR026C Overview

Standard Name
ETR1 1
Systematic Name
MRF1' , MRF1
Feature Type
ORF , Verified
2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to mitochondria, where it has a probable role in fatty acid synthesis; human MECR functionally complements the respiratory growth defect of the null mutant 2 3
Name Description
2-Enoyl Thioester Reductase 2
Comparative Info
Sequence Details


The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

ETR1 is located on the right arm of chromosome II between OLA1 P-loop ATPase and YPK3 AGC kinase; coding sequence is 1143 nucleotides long with 15 SNPs, 4 of which cause amino acid polymorphisms
Protein Details


Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Etr1p is 380 amino acids long, shorter-lived, moderate in abundance; acetylated on 5 residues, succinylated on 14 lysines, phosphorylated on 8 residues
Length (a.a.)
Mol. Weight (Da)
Isoelectric Point
Median Abundance (molecules/cell)
9388 +/- 6286
Half-life (hr)


Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.

View all ETR1 alleles in SGD search

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

Mitochondrial enoyl-ACP reductase involved in aerobic respiration and fatty acid biosynthesis

View computational annotations

Molecular Function

Manually Curated

Biological Process

Manually Curated

Cellular Component

Manually Curated
Phenotype Details


Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Non-essential gene; null is auxotrophic for myo-inositol, displays small defect in vacuolar fragmentation, slow respiratory growth, decreased usage of various nitrogen sources, sensitivity to rapamycin, decreased competitive fitness, decreased lifespan, decreased desiccation resistance
Disease Details


Disease Annotations consist of three mandatory components: a gene product, a term from the Disease Ontology (DO) controlled vocabulary and an evidence code. SGD provides manually curated DO Annotations derived from the literature. Click "Disease Details" to view all Disease information and evidence for this locus as well as diseases it shares with other genes.

Yeast ETR1 is homologous to human MECR, and has been used to study Leber’s hereditary optic neuropathy (LHON), a mitochondrial disorder characterized by complex I defect leading to sudden degeneration of retinal ganglion cells
Interaction Details


Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

Etr1p interacts physically with proteins involved in mitochondrion organization; ETR1 interacts genetically with genes involved in transcription

512 total interactions for 416 unique genes

Physical Interactions

  • Affinity Capture-MS: 29
  • Affinity Capture-RNA: 1

Genetic Interactions

  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Negative Genetic: 372
  • Phenotypic Suppression: 4
  • Positive Genetic: 86
  • Synthetic Growth Defect: 17
  • Synthetic Rescue: 1
Regulation Details


The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

ETR1 promoter is bound by Cyc8p, Gcn5p, Med4p, Spt8p, Stp1p, Sua7p, and Yap1p in response to heat; ETR1 transcription is regulated by Reb1p and Spt10p; ETR1 transcription is upregulated by Zap1p in response to zinc ion starvation
Expression Details


Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Summary Paragraph

A summary of the locus, written by SGD Biocurators following a thorough review of the literature. Links to gene names and curated GO terms are included within the Summary Paragraphs.

Last Updated: 2008-08-19

Literature Details


All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.