Primary Literature
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- Schindler N, et al. (2023) Genetic requirements for repair of lesions caused by single genomic ribonucleotides in S phase. Nat Commun 14(1):1227 PMID: 36869098
- Sui Y, et al. (2022) Ribodysgenesis: sudden genome instability in the yeast Saccharomyces cerevisiae arising from RNase H2 cleavage at genomic-embedded ribonucleotides. Nucleic Acids Res 50(12):6890-6902 PMID: 35748861
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- Cerritelli SM and El Hage A (2020) RNases H1 and H2: guardians of the stability of the nuclear genome when supply of dNTPs is limiting for DNA synthesis. Curr Genet 66(6):1073-1084 PMID: 32886170
- Cerritelli SM, et al. (2020) High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase. Nucleic Acids Res 48(8):4274-4297 PMID: 32187369
- Novarina D, et al. (2020) A Genome-Wide Screen for Genes Affecting Spontaneous Direct-Repeat Recombination in <i>Saccharomyces cerevisiae</i>. G3 (Bethesda) 10(6):1853-1867 PMID: 32265288
- Cerritelli SM and Crouch RJ (2019) RNase H2-RED carpets the path to eukaryotic RNase H2 functions. DNA Repair (Amst) 84:102736 PMID: 31761672
- Li F, et al. (2019) Apn2 resolves blocked 3' ends and suppresses Top1-induced mutagenesis at genomic rNMP sites. Nat Struct Mol Biol 26(3):155-163 PMID: 30778235
- Lockhart A, et al. (2019) RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids. Cell Rep 29(9):2890-2900.e5 PMID: 31775053
- Potenski CJ, et al. (2019) Genome instability consequences of RNase H2 Aicardi-Goutières syndrome alleles. DNA Repair (Amst) 84:102614 PMID: 30975634
- Cornelio DA, et al. (2017) Both R-loop removal and ribonucleotide excision repair activities of RNase H2 contribute substantially to chromosome stability. DNA Repair (Amst) 52:110-114 PMID: 28268090
- Graf M, et al. (2017) Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle. Cell 170(1):72-85.e14 PMID: 28666126
- Huang SN, et al. (2017) Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks. EMBO J 36(3):361-373 PMID: 27932446
- Lafuente-Barquero J, et al. (2017) The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage. PLoS Genet 13(12):e1007136 PMID: 29281624
- Williams JS, et al. (2017) The role of RNase H2 in processing ribonucleotides incorporated during DNA replication. DNA Repair (Amst) 53:52-58 PMID: 28325498
- Zimmer AD and Koshland D (2016) Differential roles of the RNases H in preventing chromosome instability. Proc Natl Acad Sci U S A 113(43):12220-12225 PMID: 27791008
- Cho JE, et al. (2015) Topoisomerase 1-dependent deletions initiated by incision at ribonucleotides are biased to the non-transcribed strand of a highly activated reporter. Nucleic Acids Res 43(19):9306-13 PMID: 26271994
- Conover HN, et al. (2015) Stimulation of Chromosomal Rearrangements by Ribonucleotides. Genetics 201(3):951-61 PMID: 26400612
- Ding J, et al. (2015) Genome-wide mapping of embedded ribonucleotides and other noncanonical nucleotides using emRiboSeq and EndoSeq. Nat Protoc 10(9):1433-44 PMID: 26313479
- Donigan KA, et al. (2015) Unlocking the steric gate of DNA polymerase η leads to increased genomic instability in Saccharomyces cerevisiae. DNA Repair (Amst) 35:1-12 PMID: 26340535
- Huang SY, et al. (2015) Topoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sites. J Biol Chem 290(22):14068-76 PMID: 25887397
- Keskin H and Storici F (2015) Defects in RNase H2 Stimulate DNA Break Repair by RNA Reverse Transcribed into cDNA. Microrna 4(2):109-16 PMID: 26456534
- O'Connell K, et al. (2015) Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity. Genetics 201(3):963-75 PMID: 26400613
- Sparks JL and Burgers PM (2015) Error-free and mutagenic processing of topoisomerase 1-provoked damage at genomic ribonucleotides. EMBO J 34(9):1259-69 PMID: 25777529
- Williams JS, et al. (2015) Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific. Nat Struct Mol Biol 22(4):291-7 PMID: 25751426
- Allen-Soltero S, et al. (2014) A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability. Mol Cell Biol 34(8):1521-34 PMID: 24550002
- El Hage A, et al. (2014) Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria. PLoS Genet 10(10):e1004716 PMID: 25357144
- Potenski CJ, et al. (2014) Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms. Nature 511(7508):251-4 PMID: 24896181
- Tumbale P, et al. (2014) Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Nature 506(7486):111-5 PMID: 24362567
- Chon H, et al. (2013) RNase H2 roles in genome integrity revealed by unlinking its activities. Nucleic Acids Res 41(5):3130-43 PMID: 23355612
- Clausen AR, et al. (2013) Structure-function analysis of ribonucleotide bypass by B family DNA replicases. Proc Natl Acad Sci U S A 110(42):16802-7 PMID: 24082122
- Ghodgaonkar MM, et al. (2013) Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol Cell 50(3):323-32 PMID: 23603115
- Kim N, et al. (2013) RNA∶DNA hybrids initiate quasi-palindrome-associated mutations in highly transcribed yeast DNA. PLoS Genet 9(11):e1003924 PMID: 24244191
- Lujan SA, et al. (2013) Ribonucleotides are signals for mismatch repair of leading-strand replication errors. Mol Cell 50(3):437-43 PMID: 23603118
- Williams JS, et al. (2013) Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA. Mol Cell 49(5):1010-5 PMID: 23375499
- Arana ME, et al. (2012) Transcriptional responses to loss of RNase H2 in Saccharomyces cerevisiae. DNA Repair (Amst) 11(12):933-41 PMID: 23079308
- Aves SJ, et al. (2012) Evolutionary diversification of eukaryotic DNA replication machinery. Subcell Biochem 62:19-35 PMID: 22918578
- Lazzaro F, et al. (2012) RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA. Mol Cell 45(1):99-110 PMID: 22244334
- Sparks JL, et al. (2012) RNase H2-initiated ribonucleotide excision repair. Mol Cell 47(6):980-6 PMID: 22864116
- Williams JS, et al. (2012) Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase ɛ. DNA Repair (Amst) 11(8):649-56 PMID: 22682724
- Clark AB, et al. (2011) Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ε. DNA Repair (Amst) 10(5):476-82 PMID: 21414850
- Ii M, et al. (2011) Epistasis analysis between homologous recombination genes in Saccharomyces cerevisiae identifies multiple repair pathways for Sgs1, Mus81-Mms4 and RNase H2. Mutat Res 714(1-2):33-43 PMID: 21741981
- Kim N, et al. (2011) Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I. Science 332(6037):1561-4 PMID: 21700875
- Nguyen TA, et al. (2011) Analysis of subunit assembly and function of the Saccharomyces cerevisiae RNase H2 complex. FEBS J 278(24):4927-42 PMID: 22004424
- Nick McElhinny SA, et al. (2010) Genome instability due to ribonucleotide incorporation into DNA. Nat Chem Biol 6(10):774-81 PMID: 20729855
- Cerritelli SM and Crouch RJ (2009) Ribonuclease H: the enzymes in eukaryotes. FEBS J 276(6):1494-505 PMID: 19228196
- Chon H, et al. (2009) Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex. Nucleic Acids Res 37(1):96-110 PMID: 19015152
- Rohman MS, et al. (2008) Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII. FEBS J 275(19):4836-49 PMID: 18721139
- Ii M and Brill SJ (2005) Roles of SGS1, MUS81, and RAD51 in the repair of lagging-strand replication defects in Saccharomyces cerevisiae. Curr Genet 48(4):213-25 PMID: 16193328
- Jeong HS, et al. (2004) RNase H2 of Saccharomyces cerevisiae is a complex of three proteins. Nucleic Acids Res 32(2):407-14 PMID: 14734815
- Arudchandran A, et al. (2000) The absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: implications for roles of RNases H in DNA replication and repair. Genes Cells 5(10):789-802 PMID: 11029655