TORC1 serine/threonine-protein kinase complex, TOR1 variant

TORC1 serine/threonine-protein kinase complex, TOR1 variant Literature

Unique References: 51
Aliases: Nutrient sensitive complex , TOR complex 1 , TORC1 , TORC1 complex , Target of rapamycin complex 1

Primary Literature

Deprez MA, et al. (2023) The nutrient-responsive CDK Pho85 primes the Sch9 kinase for its activation by TORC1. PLoS Genet 19(2):e1010641 PMID: 36791155
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Li X, et al. (2023) The TORC1 activates Rpd3L complex to deacetylate Ino80 and H2A.Z and repress autophagy. Sci Adv 9(10): eade8312. PMID: 36888706
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Prouteau M, et al. (2023) EGOC inhibits TOROID polymerization by structurally activating TORC1. Nat Struct Mol Biol. PMID: 36702972
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Gao J, et al. (2022) The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity. J Cell Biol 221(5) PMID: 35404387
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Gutiérrez-Santiago F, et al. (2022) A High-Copy Suppressor Screen Reveals a Broad Role of Prefoldin-like Bud27 in the TOR Signaling Pathway in Saccharomyces cerevisiae. Genes (Basel) 13(5) PMID: 35627133
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Nicastro R, et al. (2022) Manganese is a physiologically relevant TORC1 activator in yeast and mammals. Elife (Cambridge) 11 PMID: 35904415
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Sekiguchi T, et al. (2022) Involvement of Gtr1p in the oxidative stress response in yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun 598:107-112 PMID: 35158208
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Takuma T and Ushimaru T (2022) Vacuolar fragmentation promotes fluxes of microautophagy and micronucleophagy but not of macroautophagy. Biochem Biophys Res Commun 614:161-168 PMID: 35597153
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Tasnin MN, et al. (2022) The PI3 Kinase Complex II-PI3P-Vps27 Axis on Vacuolar Membranes is Critical for Microautophagy Induction and Nutrient Stress Adaptation. J Mol Biol 434(2):167360 PMID: 34798133
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Troutman KK, et al. (2022) Conserved Pib2 regions have distinct roles in TORC1 regulation at the vacuole. J Cell Sci 135(18) PMID: 36000409
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Waite KA, et al. (2022) Proteaphagy is specifically regulated and requires factors dispensable for general autophagy. J Biol Chem 298(1):101494 PMID: 34919962
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Wallace RL, et al. (2022) Ait1 regulates TORC1 signaling and localization in budding yeast. Elife (Cambridge) 11 PMID: 36047762
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Montella-Manuel S, et al. (2021) The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised. J Fungi (Basel) 7(11). PMID: 34829194
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Brito AS, et al. (2019) Pib2-Dependent Feedback Control of the TORC1 Signaling Network by the Npr1 Kinase. iScience 20: 415-433. PMID: 31622882
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Hu Z, et al. (2019) Multilayered Control of Protein Turnover by TORC1 and Atg1. Cell Rep 28(13): 3486-3496.e6. PMID: 31553916
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Ukai H, et al. (2018) Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane. PLoS Genet. 14(4):e1007334 PMID: 29698392
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Gonzalez S and Rallis C (2017) The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth. Front Cell Dev Biol 5:61 PMID: 28638821
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Prouteau M, et al. (2017) TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity. Nature 550(7675):265-269 PMID: 28976958
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Yerlikaya S, et al. (2016) TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae. Mol Biol Cell 27(2):397-409 PMID: 26582391
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Jacinto E and Lorberg A (2008) TOR regulation of AGC kinases in yeast and mammals. Biochem J 410(1):19-37 PMID: 18215152
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Reinke A, et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62 PMID: 14736892
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Wedaman KP, et al. (2003) Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell 14(3):1204-20 PMID: 12631735
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Loewith R, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10(3):457-68 PMID: 12408816
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Additional Literature

Caligaris M, et al. (2023) Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation. Elife (Cambridge) 12 PMID: 36749016

Shetty S, et al. (2023) TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes. EMBO J 42(5):e112344 PMID: 36691768

Bowman RW, et al. (2022) TORC1 Signaling Controls the Stability and Function of α-Arrestins Aly1 and Aly2. Biomolecules 12(4) PMID: 35454122

Schilke BA and Craig EA (2022) Essentiality of Sis1, a J-domain protein Hsp70 cochaperone, can be overcome by Tti1, a specialized PIKK chaperone. Mol Biol Cell 33(3):br3 PMID: 34935410

Tsverov J, et al. (2022) Identification of defined structural elements within TOR2 kinase required for TOR complex 2 assembly and function in Saccharomyces cerevisiae. Mol Biol Cell 33(5):ar44 PMID: 35293776

Kumar P, et al. (2018) Novel insights into TOR signalling in Saccharomyces cerevisiae through Torin2. Gene 669:15-27 PMID: 29800736

Reviews

Alao JP, et al. (2023) Interplays of AMPK and TOR in Autophagy Regulation in Yeast. Cells 12(4). PMID: 36831186

Teixeira V (2023) Special Issue: Yeast Cell Signaling Pathways (Volume 1). Int J Mol Sci 24(5). PMID: 36902357

Tyczewska A, et al. (2023) The emerging roles of tRNAs and tRNA-derived fragments during aging: Lessons from studies on model organisms. Ageing Res Rev 85:101863 PMID: 36707034

Wang Y, et al. (2023) TORC1 Signaling in Fungi: From Yeasts to Filamentous Fungi. Microorganisms 11(1). PMID: 36677510

Attfield PV (2022) Crucial aspects of metabolism and cell biology relating to industrial production and processing of Saccharomyces biomass. Crit Rev Biotechnol 1-18. PMID: 35731243

Breeden LL and Tsukiyama T (2022) Saccharomyces cerevisiae. Annu Rev Genet 56:253-278 PMID: 36449357

Carey SB and Bolger TA (2022) Translational control by helicases during cellular stress. Methods Enzymol 673:103-140 PMID: 35965004

Kumar S, et al. (2022) Yeast Crf1p: An activator in need is an activator indeed. Comput Struct Biotechnol J 20: 107-116. PMID: 34976315

Lei Y, et al. (2022) How Cells Deal with the Fluctuating Environment: Autophagy Regulation under Stress in Yeast and Mammalian Systems. Antioxidants (Basel) 11(2). PMID: 35204187

Mallén-Ponce MJ, et al. (2022) Analyzing the impact of autotrophic and heterotrophic metabolism on the nutrient regulation of TOR. New Phytol 236(4):1261-1266 PMID: 36052700

Plank M (2022) Interaction of TOR and PKA Signaling in S. cerevisiae. Biomolecules 12(2) PMID: 35204711

Schuster R and Okamoto K (2022) An overview of the molecular mechanisms of mitophagy in yeast. Biochim Biophys Acta Gen Subj 1866(11):130203 PMID: 35842014

Thorner J (2022) TOR complex 2 is a master regulator of plasma membrane homeostasis. Biochem J 479(18):1917-1940 PMID: 36149412

Bouyx C, et al. (2021) FLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the Yeast Saccharomyces cerevisiae. Pathogens 10(11). PMID: 34832664

Brink DP, et al. (2021) D-Xylose Sensing in Saccharomyces cerevisiae: Insights from D-Glucose Signaling and Native D-Xylose Utilizers. Int J Mol Sci 22(22) PMID: 34830296

Chi Z, et al. (2021) The signaling pathways involved in metabolic regulation and stress responses of the yeast-like fungi Aureobasidium spp. Biotechnol Adv 55:107898 PMID: 34974157

Hatakeyama R (2021) Pib2 as an Emerging Master Regulator of Yeast TORC1. Biomolecules 11(10) PMID: 34680122

Picazo C and Molin M (2021) Impact of Hydrogen Peroxide on Protein Synthesis in Yeast. Antioxidants (Basel) 10(6) PMID: 34204720

Schlarmann P, et al. (2021) Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis. Membranes (Basel) 11(12). PMID: 34940472

Sou IF, et al. (2021) Meiosis initiation: a story of two sexes in all creatures great and small. Biochem J 478(20):3791-3805 PMID: 34709374

Toyoda Y and Saitoh S (2021) Fission Yeast TORC2 Signaling Pathway Ensures Cell Proliferation under Glucose-Limited, Nitrogen-Replete Conditions. Biomolecules 11(10) PMID: 34680098

Toyokawa Y, et al. (2021) An overview of branched-chain amino acid aminotransferases: functional differences between mitochondrial and cytosolic isozymes in yeast and human. Appl Microbiol Biotechnol 105(21-22):8059-8072 PMID: 34622336

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Reviews

TORC1 serine/threonine-protein kinase complex, TOR1 variant Literature

Primary Literature

Additional Literature