TORC1 serine/threonine-protein kinase complex, TOR1 variant

TORC1 serine/threonine-protein kinase complex, TOR1 variant Literature

Unique References: 100
Aliases: Nutrient sensitive complex , TOR complex 1 , TORC1 , TORC1 complex , Target of rapamycin complex 1

Primary Literature

Johnson DL, et al. (2024) Ccr4-not ubiquitin ligase signaling regulates ribosomal protein homeostasis and inhibits 40S ribosomal autophagy. J Biol Chem 300(8):107582 PMID: 39025453
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Joshi K, et al. (2024) An evolutionarily conserved phosphoserine-arginine salt bridge in the interface between ribosomal proteins uS4 and uS5 regulates translational accuracy in Saccharomyces cerevisiae. Nucleic Acids Res 52(7):3989-4001 PMID: 38340338
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Kamada Y, et al. (2024) Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes. J Cell Sci 137(4) PMID: 38415789
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Kociemba J, et al. (2024) Multi-signal regulation of the GSK-3β homolog Rim11 controls meiosis entry in budding yeast. EMBO J 43(15):3256-3286 PMID: 38886580
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Naaz A, et al. (2024) Curcumin Inhibits TORC1 and Prolongs the Lifespan of Cells with Mitochondrial Dysfunction. Cells 13(17) PMID: 39273040
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Williams TD, et al. (2024) Distinct TORC1 signalling branches regulate Adc17 proteasome assembly chaperone expression. J Cell Sci 137(14) PMID: 38949052
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Zeng Q, et al. (2024) Pib2 is a cysteine sensor involved in TORC1 activation in Saccharomyces cerevisiae. Cell Rep 43(1):113599 PMID: 38127619
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Alfatah M, et al. (2023) Metabolism of glucose activates TORC1 through multiple mechanisms in Saccharomyces cerevisiae. Cell Rep 42(10):113205 PMID: 37792530
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Black A, et al. (2023) The ribosome-associated chaperone Zuo1 controls translation upon TORC1 inhibition. EMBO J 42(24):e113240 PMID: 37984430
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Blank HM, et al. (2023) Branched-chain amino acid synthesis is coupled to TOR activation early in the cell cycle in yeast. EMBO Rep 24(9):e57372 PMID: 37497662
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Deprez MA, et al. (2023) The nutrient-responsive CDK Pho85 primes the Sch9 kinase for its activation by TORC1. PLoS Genet 19(2):e1010641 PMID: 36791155
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Foltman M, et al. (2023) TOR complex 1 negatively regulates NDR kinase Cbk1 to control cell separation in budding yeast. PLoS Biol 21(8):e3002263 PMID: 37647291
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Kamada Y, et al. (2023) Yeast Tor complex 1 phosphorylates eIF4E-binding protein, Caf20. Genes Cells 28(11):789-799 PMID: 37700444
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Li X, et al. (2023) The TORC1 activates Rpd3L complex to deacetylate Ino80 and H2A.Z and repress autophagy. Sci Adv 9(10):eade8312 PMID: 36888706
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Okreglak V, et al. (2023) Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth. Nat Metab 5(10):1803-1819 PMID: 37640943
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Prouteau M, et al. (2023) EGOC inhibits TOROID polymerization by structurally activating TORC1. Nat Struct Mol Biol 30(3):273-285 PMID: 36702972
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Gao J, et al. (2022) The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity. J Cell Biol 221(5) PMID: 35404387
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Gutiérrez-Santiago F, et al. (2022) A High-Copy Suppressor Screen Reveals a Broad Role of Prefoldin-like Bud27 in the TOR Signaling Pathway in Saccharomyces cerevisiae. Genes (Basel) 13(5) PMID: 35627133
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Nicastro R, et al. (2022) Manganese is a physiologically relevant TORC1 activator in yeast and mammals. Elife 11 PMID: 35904415
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Sekiguchi T, et al. (2022) Involvement of Gtr1p in the oxidative stress response in yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun 598:107-112 PMID: 35158208
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Takuma T and Ushimaru T (2022) Vacuolar fragmentation promotes fluxes of microautophagy and micronucleophagy but not of macroautophagy. Biochem Biophys Res Commun 614 PMID: 35597153
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Tasnin MN, et al. (2022) The PI3 Kinase Complex II-PI3P-Vps27 Axis on Vacuolar Membranes is Critical for Microautophagy Induction and Nutrient Stress Adaptation. J Mol Biol 434(2):167360 PMID: 34798133
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Troutman KK, et al. (2022) Conserved Pib2 regions have distinct roles in TORC1 regulation at the vacuole. J Cell Sci 135(18) PMID: 36000409
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Waite KA, et al. (2022) Proteaphagy is specifically regulated and requires factors dispensable for general autophagy. J Biol Chem 298(1):101494 PMID: 34919962
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Wallace RL, et al. (2022) Ait1 regulates TORC1 signaling and localization in budding yeast. Elife 11 PMID: 36047762
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Montella-Manuel S, et al. (2021) The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised. J Fungi (Basel) 7(11) PMID: 34829194
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Brito AS, et al. (2019) Pib2-Dependent Feedback Control of the TORC1 Signaling Network by the Npr1 Kinase. iScience 20:415-433 PMID: 31622882
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Hatakeyama R and De Virgilio C (2019) TORC1 specifically inhibits microautophagy through ESCRT-0. Curr Genet 65(5):1243-1249 PMID: 31041524
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Hu Z, et al. (2019) Multilayered Control of Protein Turnover by TORC1 and Atg1. Cell Rep 28(13):3486-3496.e6 PMID: 31553916
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Ukai H, et al. (2018) Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane. PLoS Genet 14(4):e1007334 PMID: 29698392
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Yamamoto K, et al. (2018) TORC1 signaling regulates DNA replication via DNA replication protein levels. Biochem Biophys Res Commun 505(4): 1128-1133. PMID: 30316513
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Gonzalez S and Rallis C (2017) The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth. Front Cell Dev Biol 5:61 PMID: 28638821
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Kamada Y (2017) Novel tRNA function in amino acid sensing of yeast Tor complex1. Genes Cells 22(2):135-147 PMID: 28084665
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Prouteau M, et al. (2017) TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity. Nature 550(7675):265-269 PMID: 28976958
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Bojsen R, et al. (2016) A common mechanism involving the TORC1 pathway can lead to amphotericin B-persistence in biofilm and planktonic Saccharomyces cerevisiae populations. Sci Rep 6:21874 PMID: 26903175
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Yerlikaya S, et al. (2016) TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae. Mol Biol Cell 27(2):397-409 PMID: 26582391
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Jacinto E and Lorberg A (2008) TOR regulation of AGC kinases in yeast and mammals. Biochem J 410(1):19-37 PMID: 18215152
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Reinke A, et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62 PMID: 14736892
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Wedaman KP, et al. (2003) Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell 14(3):1204-20 PMID: 12631735
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Loewith R, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10(3):457-68 PMID: 12408816
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Additional Literature

Caligaris M and De Virgilio C (2024) Proxies introduce bias in decoding TORC1 activity. MicroPubl Biol 2024 PMID: 38605723

Guarini N, et al. (2024) Phosphoregulation of the yeast Pma1 H+-ATPase autoinhibitory domain involves the Ptk1/2 kinases and the Glc7 PP1 phosphatase and is under TORC1 control. PLoS Genet 20(1):e1011121 PMID: 38227612

Hofer SJ, et al. (2024) Spermidine is essential for fasting-mediated autophagy and longevity. Nat Cell Biol 26(9):1571-1584 PMID: 39117797

Litsios A, et al. (2024) Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle. Cell 187(6):1490-1507.e21 PMID: 38452761

Lucca C, et al. (2024) Sch9S6K controls DNA repair and DNA damage response efficiency in aging cells. Cell Rep 43(6):114281 PMID: 38805395

Mondal S, et al. (2024) Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation. Heliyon 10(19):e38786 PMID: 39416838

Caligaris M, et al. (2023) Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation. Elife 12 PMID: 36749016

Liang J, et al. (2023) Divergence of TORC1-mediated stress response leads to novel acquired stress resistance in a pathogenic yeast. PLoS Pathog 19(10):e1011748 PMID: 37871123

Shetty S, et al. (2023) TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes. EMBO J 42(5):e112344 PMID: 36691768

Tate JJ, et al. (2023) TorC1 and nitrogen catabolite repression control of integrated GABA shunt and retrograde pathway gene expression. Yeast 40(8):318-332 PMID: 36960709

Bowman RW, et al. (2022) TORC1 Signaling Controls the Stability and Function of α-Arrestins Aly1 and Aly2. Biomolecules 12(4) PMID: 35454122

Schilke BA and Craig EA (2022) Essentiality of Sis1, a J-domain protein Hsp70 cochaperone, can be overcome by Tti1, a specialized PIKK chaperone. Mol Biol Cell 33(3):br3 PMID: 34935410

Tsverov J, et al. (2022) Identification of defined structural elements within TOR2 kinase required for TOR complex 2 assembly and function in Saccharomyces cerevisiae. Mol Biol Cell 33(5):ar44 PMID: 35293776

Anandapadamanaban M, et al. (2019) Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science 366(6462):203-210 PMID: 31601764

Kumar P, et al. (2018) Novel insights into TOR signalling in Saccharomyces cerevisiae through Torin2. Gene 669:15-27 PMID: 29800736

Conrad M, et al. (2017) The nutrient transceptor/PKA pathway functions independently of TOR and responds to leucine and Gcn2 in a TOR-independent manner. FEMS Yeast Res 17(5). PMID: 28810702

Yu SC, et al. (2016) Nutrient supplements boost yeast transformation efficiency. Sci Rep 6:35738 PMID: 27760994

Reviews

Bischof L, et al. (2024) Functional Conservation of the Small GTPase Rho5/Rac1-A Tale of Yeast and Men. Cells 13(6) PMID: 38534316

Bi X (2024) Hmo1: A versatile member of the high mobility group box family of chromosomal architecture proteins. World J Biol Chem 15(1):97938 PMID: 39156122

Bui THD and Labedzka-Dmoch K (2024) RetroGREAT signaling: The lessons we learn from yeast. IUBMB Life 76(1):26-37 PMID: 37565710

Čáp M and Palková Z (2024) Non-Coding RNAs: Regulators of Stress, Ageing, and Developmental Decisions in Yeast? Cells 13(7) PMID: 38607038

Holzer E, et al. (2024) The Role of ATG9 Vesicles in Autophagosome Biogenesis. J Mol Biol 436(15):168489 PMID: 38342428

Kuchitsu Y and Taguchi T (2024) Lysosomal microautophagy: an emerging dimension in mammalian autophagy. Trends Cell Biol 34(7):606-616 PMID: 38104013

Metur SP and Klionsky DJ (2024) Nutrient-dependent signaling pathways that control autophagy in yeast. FEBS Lett 598(1):32-47 PMID: 37758520

Obata F and Miura M (2024) Regulatory Mechanisms of Aging Through the Nutritional and Metabolic Control of Amino Acid Signaling in Model Organisms. Annu Rev Genet PMID: 38857535

Ohtsuka H, et al. (2024) Low-Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe. Adv Biol (Weinh) 8(5):e2400138 PMID: 38616173

Wong Z and Ong EBB (2024) Unravelling bacterial virulence factors in yeast: From identification to the elucidation of their mechanisms of action. Arch Microbiol 206(7):303 PMID: 38878203

Alao JP, et al. (2023) Interplays of AMPK and TOR in Autophagy Regulation in Yeast. Cells 12(4) PMID: 36831186

Attfield PV (2023) Crucial aspects of metabolism and cell biology relating to industrial production and processing of Saccharomyces biomass. Crit Rev Biotechnol 43(6):920-937 PMID: 35731243

Barman P, et al. (2023) UPS writes a new saga of SAGA. Biochim Biophys Acta Gene Regul Mech 1866(4):194981 PMID: 37657588

Foltman M and Sanchez-Diaz A (2023) TOR Complex 1: Orchestrating Nutrient Signaling and Cell Cycle Progression. Int J Mol Sci 24(21) PMID: 37958727

Gutiérrez-Santiago F and Navarro F (2023) Transcription by the Three RNA Polymerases under the Control of the TOR Signaling Pathway in Saccharomyces cerevisiae. Biomolecules 13(4) PMID: 37189389

Lakin-Thomas P (2023) The Case for the Target of Rapamycin Pathway as a Candidate Circadian Oscillator. Int J Mol Sci 24(17) PMID: 37686112

Leite AC, et al. (2023) Mitochondria and the cell cycle in budding yeast. Int J Biochem Cell Biol 161:106444 PMID: 37419443

Lei Y and Klionsky DJ (2023) Transcriptional regulation of autophagy and its implications in human disease. Cell Death Differ 30(6):1416-1429 PMID: 37045910

Santana-Sosa S, et al. (2023) A Yeast Mitotic Tale for the Nucleus and the Vacuoles to Embrace. Int J Mol Sci 24(12) PMID: 37372977

Teixeira V (2023) Special Issue: Yeast Cell Signaling Pathways (Volume 1). Int J Mol Sci 24(5) PMID: 36902357

Tyczewska A, et al. (2023) The emerging roles of tRNAs and tRNA-derived fragments during aging: Lessons from studies on model organisms. Ageing Res Rev 85:101863 PMID: 36707034

Uvdal P and Shashkova S (2023) The Effect of Calorie Restriction on Protein Quality Control in Yeast. Biomolecules 13(5) PMID: 37238710

Wang Y, et al. (2023) TORC1 Signaling in Fungi: From Yeasts to Filamentous Fungi. Microorganisms 11(1) PMID: 36677510

Breeden LL and Tsukiyama T (2022) Quiescence in Saccharomyces cerevisiae. Annu Rev Genet 56:253-278 PMID: 36449357

Carey SB and Bolger TA (2022) Translational control by helicases during cellular stress. Methods Enzymol 673:103-140 PMID: 35965004

Chi Z, et al. (2022) The signaling pathways involved in metabolic regulation and stress responses of the yeast-like fungi Aureobasidium spp. Biotechnol Adv 55:107898 PMID: 34974157

Kumar S, et al. (2022) Yeast Crf1p: An activator in need is an activator indeed. Comput Struct Biotechnol J 20:107-116 PMID: 34976315

Lei Y, et al. (2022) How Cells Deal with the Fluctuating Environment: Autophagy Regulation under Stress in Yeast and Mammalian Systems. Antioxidants (Basel) 11(2) PMID: 35204187

Mallén-Ponce MJ, et al. (2022) Analyzing the impact of autotrophic and heterotrophic metabolism on the nutrient regulation of TOR. New Phytol 236(4):1261-1266 PMID: 36052700

Plank M (2022) Interaction of TOR and PKA Signaling in S. cerevisiae. Biomolecules 12(2) PMID: 35204711

Schuster R and Okamoto K (2022) An overview of the molecular mechanisms of mitophagy in yeast. Biochim Biophys Acta Gen Subj 1866(11):130203 PMID: 35842014

Thorner J (2022) TOR complex 2 is a master regulator of plasma membrane homeostasis. Biochem J 479(18):1917-1940 PMID: 36149412

Aledo JC (2021) The Role of Methionine Residues in the Regulation of Liquid-Liquid Phase Separation. Biomolecules 11(8) PMID: 34439914

Bouyx C, et al. (2021) FLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the Yeast Saccharomyces cerevisiae. Pathogens 10(11) PMID: 34832664

Brink DP, et al. (2021) D-Xylose Sensing in Saccharomyces cerevisiae: Insights from D-Glucose Signaling and Native D-Xylose Utilizers. Int J Mol Sci 22(22) PMID: 34830296

Hatakeyama R (2021) Pib2 as an Emerging Master Regulator of Yeast TORC1. Biomolecules 11(10) PMID: 34680122

Picazo C and Molin M (2021) Impact of Hydrogen Peroxide on Protein Synthesis in Yeast. Antioxidants (Basel) 10(6) PMID: 34204720

Schlarmann P, et al. (2021) Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis. Membranes (Basel) 11(12) PMID: 34940472

Sou IF, et al. (2021) Meiosis initiation: a story of two sexes in all creatures great and small. Biochem J 478(20):3791-3805 PMID: 34709374

Toyoda Y and Saitoh S (2021) Fission Yeast TORC2 Signaling Pathway Ensures Cell Proliferation under Glucose-Limited, Nitrogen-Replete Conditions. Biomolecules 11(10) PMID: 34680098

Toyokawa Y, et al. (2021) An overview of branched-chain amino acid aminotransferases: functional differences between mitochondrial and cytosolic isozymes in yeast and human. Appl Microbiol Biotechnol 105(21-22):8059-8072 PMID: 34622336

Alam JM and Noda NN (2020) In vitro reconstitution of autophagic processes. Biochem Soc Trans 48(5):2003-2014 PMID: 32897375

Medkour Y, et al. (2017) Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging. None 2017 PMID: 28593023

TORC1 serine/threonine-protein kinase complex, TOR1 variant Literature TEXT HERE

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Reviews

TORC1 serine/threonine-protein kinase complex, TOR1 variant Literature

Primary Literature

Additional Literature