Complex: Phosphatidylinositol 3-kinase complex II
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1677
- Systematic Name
- VPS15:VPS30:VPS34:VPS38
- SGD ID
- SGD:S000218064
- Aliases
- BECN1:VPS15:VPS34:VPS38 ; PI3KCII ; VPS34 PI3-kinase complex II ; Vps34 PtdIns 3 kinase complex II ; Vps34 Ptdins 3-kinase complex II
- Description
- Catalyzes phosphorylation of phosphatidyl inositol, one of the major phospholipids in the cell, specifically at the d-3 position of the inositol ring, to generate PtdIns(3)P. Directs the synthesis of a specific endosomal pool of PtdIns3P, which is required for recruitment/activation of the retromer complex, thereby ensuring efficient endosome-to-Golgi retrograde transport.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables 1-phosphatidylinositol-3-kinase activity (IDA)
- enables ATP binding (IDA)
- enables protein serine/threonine kinase activity (BSR)
- Biological Process
-
- involved in late endosome to vacuole transport (BSR)
- involved in phosphatidylinositol phosphate biosynthetic process (IDA)
- Cellular Component
-
- located in Golgi membrane (BSR)
- located in endosome membrane (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Obara K, et al. (2008) Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae. Genes Cells 13(6):537-47 PMID: 18533003
Resources
IntAct | ModelArchive | PDB:5DFZ | PDB:5KC2 ... Show all Show fewer