Primary Literature
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- Norris K, et al. (2021) Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease. J Biol Chem 296:100207 PMID: 33334879
- Nüske E, et al. (2020) Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells. Biol Open 9(7) PMID: 32554487
- Sharma S, et al. (2020) Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays a crucial role in eIF2B-mediated translation regulation and survival under stress conditions. J Genet Eng Biotechnol 18(1):15 PMID: 32476094
- Gordiyenko Y, et al. (2019) Structural basis for the inhibition of translation through eIF2α phosphorylation. Nat Commun 10(1):2640 PMID: 31201334
- Marini G and Pigino G (2019) Yeast membraneless compartments revealed by correlative light microscopy and electron tomography. Methods Cell Biol 152:103-117 PMID: 31326017
- Davis López SA, et al. (2018) Evolutionary engineering improves tolerance for medium-chain alcohols in <i>Saccharomyces cerevisiae</i>. Biotechnol Biofuels 11:90 PMID: 29619086
- Moon SL and Parker R (2018) Analysis of eIF2B bodies and their relationships with stress granules and P-bodies. Sci Rep 8(1):12264 PMID: 30115954
- Egbe NE, et al. (2017) Farnesol inhibits translation to limit growth and filamentation in <i>C. albicans</i> and <i>S. cerevisiae</i>. Microb Cell 4(9):294-304 PMID: 28913344
- Falletta P, et al. (2017) Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma. Genes Dev 31(1):18-33 PMID: 28096186
- Sharma S, et al. (2017) Role of Saccharomyces cerevisiae TAN1 (tRNA acetyltransferase) in eukaryotic initiation factor 2B (eIF2B)-mediated translation control and stress response. 3 Biotech 7(3):223 PMID: 28677085
- Beilsten-Edmands V, et al. (2015) eIF2 interactions with initiator tRNA and eIF2B are regulated by post-translational modifications and conformational dynamics. Cell Discov 1:15020 PMID: 27462419
- Swidah R, et al. (2015) Butanol production in S. cerevisiae via a synthetic ABE pathway is enhanced by specific metabolic engineering and butanol resistance. Biotechnol Biofuels 8:97 PMID: 26175798
- Wortham NC and Proud CG (2015) eIF2B: recent structural and functional insights into a key regulator of translation. Biochem Soc Trans 43(6):1234-40 PMID: 26614666
- Gordiyenko Y, et al. (2014) eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core. Nat Commun 5:3902 PMID: 24852487
- Browne CM, et al. (2013) The yeast eukaryotic translation initiation factor 2B translation initiation complex interacts with the fatty acid synthesis enzyme YBR159W and endoplasmic reticulum membranes. Mol Cell Biol 33(5):1041-56 PMID: 23263984
- de Almeida RA, et al. (2013) A yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM disease. PLoS One 8(1):e53958 PMID: 23335982
- Firczuk H, et al. (2013) An in vivo control map for the eukaryotic mRNA translation machinery. Mol Syst Biol 9:635 PMID: 23340841
- Jennings MD, et al. (2013) eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation. Genes Dev 27(24):2696-707 PMID: 24352424
- Gai Z, et al. (2012) The binding mechanism of eIF2β with its partner proteins, eIF5 and eIF2Bε. Biochem Biophys Res Commun 423(3):515-9 PMID: 22683627
- Reid PJ, et al. (2012) Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation. J Biol Chem 287(11):8275-85 PMID: 22238343
- Elsby R, et al. (2011) The alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus. J Virol 85(19):9716-25 PMID: 21795329
- Singh CR, et al. (2011) Mechanisms of translational regulation by a human eIF5-mimic protein. Nucleic Acids Res 39(19):8314-28 PMID: 21745818
- Dev K, et al. (2010) The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo. Mol Cell Biol 30(21):5218-33 PMID: 20805354
- Jennings MD and Pavitt GD (2010) eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation. Nature 465(7296):378-81 PMID: 20485439
- Rosenfeld AB and Racaniello VR (2010) Components of the multifactor complex needed for internal initiation by the IRES of hepatitis C virus in Saccharomyces cerevisiae. RNA Biol 7(5):596-605 PMID: 20935471
- Taylor EJ, et al. (2010) Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body. Mol Biol Cell 21(13):2202-16 PMID: 20444979
- Deniz N, et al. (2009) Translation initiation factors are not required for Dicistroviridae IRES function in vivo. RNA 15(5):932-46 PMID: 19299549
- Dev K, et al. (2009) Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation. J Mol Biol 392(3):701-22 PMID: 19616556
- Hiyama TB, et al. (2009) Crystal structure of the alpha subunit of human translation initiation factor 2B. J Mol Biol 392(4):937-51 PMID: 19631657
- Motlekar N, et al. (2009) Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast. Assay Drug Dev Technol 7(5):479-94 PMID: 19715453
- Kito K, et al. (2008) Discrimination between stable and dynamic components of protein complexes by means of quantitative proteomics. Proteomics 8(12):2366-70 PMID: 18563728
- Campbell SG and Ashe MP (2007) An approach to studying the localization and dynamics of eukaryotic translation factors in live yeast cells. Methods Enzymol 431:33-45 PMID: 17923229
- Kito K, et al. (2007) A synthetic protein approach toward accurate mass spectrometric quantification of component stoichiometry of multiprotein complexes. J Proteome Res 6(2):792-800 PMID: 17269735
- Mohammad-Qureshi SS, et al. (2007) Purification of FLAG-tagged eukaryotic initiation factor 2B complexes, subcomplexes, and fragments from Saccharomyces cerevisiae. Methods Enzymol 431:1-13 PMID: 17923227
- Mohammad-Qureshi SS, et al. (2007) Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange. Mol Cell Biol 27(14):5225-34 PMID: 17526738
- Singh CR, et al. (2007) Change in nutritional status modulates the abundance of critical pre-initiation intermediate complexes during translation initiation in vivo. J Mol Biol 370(2):315-30 PMID: 17512538
- Alone PV and Dever TE (2006) Direct binding of translation initiation factor eIF2gamma-G domain to its GTPase-activating and GDP-GTP exchange factors eIF5 and eIF2B epsilon. J Biol Chem 281(18):12636-44 PMID: 16522633
- Campbell SG and Ashe MP (2006) Localization of the translational guanine nucleotide exchange factor eIF2B: a common theme for GEFs? Cell Cycle 5(7):678-80 PMID: 16582624
- Singh CR, et al. (2006) An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation. EMBO J 25(19):4537-46 PMID: 16990799
- Campbell SG, et al. (2005) Dynamic cycling of eIF2 through a large eIF2B-containing cytoplasmic body: implications for translation control. J Cell Biol 170(6):925-34 PMID: 16157703
- Dey M, et al. (2005) PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha. Mol Cell Biol 25(8):3063-75 PMID: 15798194
- Pavitt GD (2005) eIF2B, a mediator of general and gene-specific translational control. Biochem Soc Trans 33(Pt 6):1487-92 PMID: 16246152
- Proud CG (2005) eIF2 and the control of cell physiology. Semin Cell Dev Biol 16(1):3-12 PMID: 15659334
- Boesen T, et al. (2004) Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue. J Biol Chem 279(11):10584-92 PMID: 14681227
- Bumann M, et al. (2004) Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. J Biol Chem 279(35):37087-94 PMID: 15215245
- Hinnebusch AG, et al. (2004) Study of translational control of eukaryotic gene expression using yeast. Ann N Y Acad Sci 1038:60-74 PMID: 15838098
- Richardson JP, et al. (2004) Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity. Mol Cell Biol 24(6):2352-63 PMID: 14993275
- Dhaliwal S and Hoffman DW (2003) The crystal structure of the N-terminal region of the alpha subunit of translation initiation factor 2 (eIF2alpha) from Saccharomyces cerevisiae provides a view of the loop containing serine 51, the target of the eIF2alpha-specific kinases. J Mol Biol 334(2):187-95 PMID: 14607111
- Gomez E, et al. (2002) Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiation. EMBO J 21(19):5292-301 PMID: 12356745
- Ashe MP, et al. (2001) A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols. EMBO J 20(22):6464-74 PMID: 11707417
- Clemens MJ (2001) Initiation factor eIF2 alpha phosphorylation in stress responses and apoptosis. Prog Mol Subcell Biol 27 PMID: 11575161
- Erickson FL, et al. (2001) Minimum requirements for the function of eukaryotic translation initiation factor 2. Genetics 158(1):123-32 PMID: 11333223
- Kimball SR (2001) Regulation of translation initiation by amino acids in eukaryotic cells. Prog Mol Subcell Biol 26 PMID: 11575165
- Krishnamoorthy T, et al. (2001) Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation. Mol Cell Biol 21(15):5018-30 PMID: 11438658
- Nika J, et al. (2001) Biochemical analysis of the eIF2beta gamma complex reveals a structural function for eIF2alpha in catalyzed nucleotide exchange. J Biol Chem 276(2):1051-6 PMID: 11042214
- Williams DD, et al. (2001) Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster. J Biol Chem 276(6):3733-42 PMID: 11060303
- Chang LY, et al. (2000) Functional complementation by wheat eIF2alpha in the yeast GCN2-mediated pathway. Biochem Biophys Res Commun 279(2):468-74 PMID: 11118310
- Gomez E and Pavitt GD (2000) Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation. Mol Cell Biol 20(11):3965-76 PMID: 10805739
- Nika J, et al. (2000) Purification and kinetic analysis of eIF2B from Saccharomyces cerevisiae. J Biol Chem 275(34):26011-7 PMID: 10852917
- Thompson GM, et al. (2000) Conserved sequences in the beta subunit of archaeal and eukaryal translation initiation factor 2 (eIF2), absent from eIF5, mediate interaction with eIF2gamma. Biochem J 347 Pt 3(Pt 3):703-9 PMID: 10769173
- Asano K, et al. (1999) Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2. EMBO J 18(6):1673-88 PMID: 10075937
- Mueller PP, et al. (1998) A ribosomal protein is required for translational regulation of GCN4 mRNA. Evidence for involvement of the ribosome in eIF2 recycling. J Biol Chem 273(49):32870-7 PMID: 9830035
- Pavitt GD, et al. (1998) eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange. Genes Dev 12(4):514-26 PMID: 9472020
- Pavitt GD, et al. (1997) Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2. Mol Cell Biol 17(3):1298-313 PMID: 9032257
- Price NT, et al. (1996) Cloning of cDNA for the gamma-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Biochem J 318 ( Pt 2)(Pt 2):631-6 PMID: 8809057
- Price NT, et al. (1996) eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast. Biochem J 318 ( Pt 2)(Pt 2):637-43 PMID: 8929216
- Yang W and Hinnebusch AG (1996) Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2. Mol Cell Biol 16(11):6603-16 PMID: 8887689
- Cigan AM, et al. (1993) A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast. Proc Natl Acad Sci U S A 90(11):5350-4 PMID: 8506384