Zhang L, et al. (2025) VAC14 oligomerization is essential for the function of the FAB1/PIKfyve-VAC14-FIG4 complex. Mol Biol Cell mbcE24110490 PMID:40305106
Steinfeld N, et al. (2021) Simultaneous Detection of Phosphoinositide Lipids by Radioactive Metabolic Labeling. Methods Mol Biol 2251:1-17 PMID:33481228
Wong S, et al. (2020) Cargo Release from Myosin V Requires the Convergence of Parallel Pathways that Phosphorylate and Ubiquitylate the Cargo Adaptor. Curr Biol 30(22):4399-4412.e7 PMID:32916113
Takeda E, et al. (2018) Vacuole-mediated selective regulation of TORC1-Sch9 signaling following oxidative stress. Mol Biol Cell 29(4):510-522 PMID:29237820
Jin N, et al. (2017) Early protection to stress mediated by CDK-dependent PI3,5P2 signaling from the vacuole/lysosome. J Cell Biol 216(7):2075-2090 PMID:28637746
Lang MJ, et al. (2017) An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels. Mol Biol Cell 28(7):858-864 PMID:28148651
Yau RG, et al. (2017) Spatial regulation of organelle release from myosin V transport by p21-activated kinases. J Cell Biol 216(6):1557-1566 PMID:28495836
Li SC, et al. (2014) The signaling lipid PI(3,5)P₂ stabilizes V₁-V(o) sector interactions and activates the V-ATPase. Mol Biol Cell 25(8):1251-62 PMID:24523285
McCartney AJ, et al. (2014) Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression. Proc Natl Acad Sci U S A 111(45):E4896-905 PMID:25355904
Yau RG, et al. (2014) Release from myosin V via regulated recruitment of an E3 ubiquitin ligase controls organelle localization. Dev Cell 28(5):520-33 PMID:24636257
Eves PT, et al. (2012) Overlap of cargo binding sites on myosin V coordinates the inheritance of diverse cargoes. J Cell Biol 198(1):69-85 PMID:22753895
Jin Y, et al. (2011) Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex. Dev Cell 21(6):1156-70 PMID:22172676
Sultana A, et al. (2011) The activation cycle of Rab GTPase Ypt32 reveals structural determinants of effector recruitment and GDI binding. FEBS Lett 585(22):3520-7 PMID:22024479
Birkeland SR, et al. (2010) Discovery of mutations in Saccharomyces cerevisiae by pooled linkage analysis and whole-genome sequencing. Genetics 186(4):1127-37 PMID:20923977
Dong XP, et al. (2010) PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun 1(4):38 PMID:20802798
Jin Y, et al. (2009) PTC1 is required for vacuole inheritance and promotes the association of the myosin-V vacuole-specific receptor complex. Mol Biol Cell 20(5):1312-23 PMID:19116310
Jin N, et al. (2008) VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J 27(24):3221-34 PMID:19037259
Lipatova Z, et al. (2008) Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion. Mol Biol Cell 19(10):4177-87 PMID:18653471
Chow CY, et al. (2007) Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature 448(7149):68-72 PMID:17572665
Duex JE, et al. (2006) The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover. J Cell Biol 172(5):693-704 PMID:16492811
Duex JE, et al. (2006) Phosphoinositide 5-phosphatase Fig 4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levels. Eukaryot Cell 5(4):723-31 PMID:16607019
Pashkova N, et al. (2005) Myosin V attachment to cargo requires the tight association of two functional subdomains. J Cell Biol 168(3):359-64 PMID:15684027
Pashkova N, et al. (2005) A point mutation in the cargo-binding domain of myosin V affects its interaction with multiple cargoes. Eukaryot Cell 4(4):787-98 PMID:15821138
Wang CW, et al. (2003) Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage. J Cell Biol 163(5):973-85 PMID:14662743
Bonangelino CJ, et al. (2002) Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J Cell Biol 156(6):1015-28 PMID:11889142
Gary JD, et al. (2002) Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol Biol Cell 13(4):1238-51 PMID:11950935
Catlett NL, et al. (2000) Two distinct regions in a yeast myosin-V tail domain are required for the movement of different cargoes. J Cell Biol 150(3):513-26 PMID:10931864
Scott SV, et al. (2000) Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J Biol Chem 275(33):25840-9 PMID:10837477
Bryant NJ, et al. (1998) Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment. J Cell Biol 142(3):651-63 PMID:9700156
Catlett NL and Weisman LS (1998) The terminal tail region of a yeast myosin-V mediates its attachment to vacuole membranes and sites of polarized growth. Proc Natl Acad Sci U S A 95(25):14799-804 PMID:9843969
Gary JD, et al. (1998) Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. J Cell Biol 143(1):65-79 PMID:9763421
Wang YX, et al. (1998) Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. J Cell Biol 140(5):1063-74 PMID:9490720
Bonangelino CJ, et al. (1997) Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology. Mol Cell Biol 17(12):6847-58 PMID:9372916
Hill KL, et al. (1996) Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae. J Cell Biol 135(6 Pt 1):1535-49 PMID:8978821
Wang YX, et al. (1996) Multiple classes of yeast mutants are defective in vacuole partitioning yet target vacuole proteins correctly. Mol Biol Cell 7(9):1375-89 PMID:8885233
Nicolson TA, et al. (1995) A truncated form of the Pho80 cyclin redirects the Pho85 kinase to disrupt vacuole inheritance in S. cerevisiae. J Cell Biol 130(4):835-45 PMID:7642701
Weisman LS and Wickner W (1992) Molecular characterization of VAC1, a gene required for vacuole inheritance and vacuole protein sorting. J Biol Chem 267(1):618-23 PMID:1730622
Weisman LS, et al. (1990) Mutants of Saccharomyces cerevisiae that block intervacuole vesicular traffic and vacuole division and segregation. Proc Natl Acad Sci U S A 87(3):1076-80 PMID:1689059
Weisman LS, et al. (1987) Multiple methods of visualizing the yeast vacuole permit evaluation of its morphology and inheritance during the cell cycle. J Cell Biol 105(4):1539-47 PMID:2444598