Braymer JJ, et al. (2024) Requirements for the biogenesis of [2Fe-2S] proteins in the human and yeast cytosol. Proc Natl Acad Sci U S A 121(21):e2400740121 PMID:38743629
Carvalho FA, et al. (2023) Hsp90 and metal-binding J-protein family chaperones are not critically involved in cellular iron-sulfur protein assembly and iron regulation in yeast. FEBS Lett 597(13):1718-1732 PMID:36932975
Mühlenhoff U, et al. (2022) The iron-sulfur cluster assembly (ISC) protein Iba57 executes a tetrahydrofolate-independent function in mitochondrial [4Fe-4S] protein maturation. J Biol Chem 298(10):102465 PMID:36075292
Ellinghaus TL, et al. (2021) Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Sci Adv 7(52):eabk2392 PMID:34936443
Mühlenhoff U, et al. (2020) Glutaredoxins and iron-sulfur protein biogenesis at the interface of redox biology and iron metabolism. Biol Chem 401(12):1407-1428 PMID:33031050
Braymer JJ, et al. (2019) Depletion of thiol reducing capacity impairs cytosolic but not mitochondrial iron-sulfur protein assembly machineries. Biochim Biophys Acta Mol Cell Res 1866(2):240-251 PMID:30419257
Uzarska MA, et al. (2018) Conserved functions of Arabidopsis mitochondrial late-acting maturation factors in the trafficking of iron‑sulfur clusters. Biochim Biophys Acta Mol Cell Res 1865(9):1250-1259 PMID:29902489
Garcia-Santamarina S, et al. (2017)Cryptococcus neoformans Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress. mBio 8(5) PMID:29089435
Li H, et al. (2017) The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements. J Biol Chem 292(27):11445-11451 PMID:28515324
Mühlenhoff U, et al. (2017) Specialized function of yeast Isa1 and Isa2 proteins in the maturation of mitochondrial [4Fe-4S] proteins. J Biol Chem 292(43):17979 PMID:29079644
Netz DJ, et al. (2016) The conserved protein Dre2 uses essential [2Fe-2S] and [4Fe-4S] clusters for its function in cytosolic iron-sulfur protein assembly. Biochem J 473(14):2073-85 PMID:27166425
Glatt S, et al. (2015) Structure of the Kti11/Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic elongation factor 2. Structure 23(1):149-160 PMID:25543256
Moseler A, et al. (2015) The mitochondrial monothiol glutaredoxin S15 is essential for iron-sulfur protein maturation in Arabidopsis thaliana. Proc Natl Acad Sci U S A 112(44):13735-40 PMID:26483494
Mühlenhoff U, et al. (2015) Compartmentalization of iron between mitochondria and the cytosol and its regulation. Eur J Cell Biol 94(7-9):292-308 PMID:26116073
Paul VD and Lill R (2015) Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. Biochim Biophys Acta 1853(6):1528-39 PMID:25583461
Paul VD, et al. (2015) The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion. Elife 4:e08231 PMID:26182403
Webert H, et al. (2014) Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin. Nat Commun 5:5013 PMID:25358379
Haunhorst P, et al. (2013) Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation. Mol Biol Cell 24(12):1895-903 PMID:23615448
Lewrenz I, et al. (2013) The functional interaction of mitochondrial Hsp70s with the escort protein Zim17 is critical for Fe/S biogenesis and substrate interaction at the inner membrane preprotein translocase. J Biol Chem 288(43):30931-43 PMID:24030826
Uzarska MA, et al. (2013) The mitochondrial Hsp70 chaperone Ssq1 facilitates Fe/S cluster transfer from Isu1 to Grx5 by complex formation. Mol Biol Cell 24(12):1830-41 PMID:23615440
Netz DJ, et al. (2012) A bridging [4Fe-4S] cluster and nucleotide binding are essential for function of the Cfd1-Nbp35 complex as a scaffold in iron-sulfur protein maturation. J Biol Chem 287(15):12365-78 PMID:22362766
Sheftel AD, et al. (2012) The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation. Mol Biol Cell 23(7):1157-66 PMID:22323289
Stehling O, et al. (2012) MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Science 337(6091):195-9 PMID:22678362
Castells-Roca L, et al. (2011) The oxidative stress response in yeast cells involves changes in the stability of Aft1 regulon mRNAs. Mol Microbiol 81(1):232-48 PMID:21542867
Hoffmann B, et al. (2011) The multidomain thioredoxin-monothiol glutaredoxins represent a distinct functional group. Antioxid Redox Signal 15(1):19-30 PMID:21299470
Mühlenhoff U, et al. (2011) Specialized function of yeast Isa1 and Isa2 proteins in the maturation of mitochondrial [4Fe-4S] proteins. J Biol Chem 286(48):41205-41216 PMID:21987576
Navarro-Sastre A, et al. (2011) A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins. Am J Hum Genet 89(5):656-67 PMID:22077971
Netz DJ, et al. (2011) Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes. Nat Chem Biol 8(1):125-32 PMID:22119860
Ozeir M, et al. (2011) Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency. Chem Biol 18(9):1134-42 PMID:21944752
Ihrig J, et al. (2010) Iron regulation through the back door: iron-dependent metabolite levels contribute to transcriptional adaptation to iron deprivation in Saccharomyces cerevisiae. Eukaryot Cell 9(3):460-71 PMID:20008079
Mühlenhoff U, et al. (2010) Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster. Cell Metab 12(4):373-385 PMID:20889129
Sheftel AD, et al. (2010) Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis. Proc Natl Acad Sci U S A 107(26):11775-80 PMID:20547883
Urzica E, et al. (2009) Crucial role of conserved cysteine residues in the assembly of two iron-sulfur clusters on the CIA protein Nar1. Biochemistry 48(22):4946-58 PMID:19385603
Bych K, et al. (2008) The essential cytosolic iron-sulfur protein Nbp35 acts without Cfd1 partner in the green lineage. J Biol Chem 283(51):35797-804 PMID:18957412
Gelling C, et al. (2008) Mitochondrial Iba57p is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes. Mol Cell Biol 28(5):1851-61 PMID:18086897
Hausmann A, et al. (2008) Cellular and mitochondrial remodeling upon defects in iron-sulfur protein biogenesis. J Biol Chem 283(13):8318-30 PMID:18227070
Lill R and Mühlenhoff U (2008) Maturation of iron-sulfur proteins in eukaryotes: mechanisms, connected processes, and diseases. Annu Rev Biochem 77:669-700 PMID:18366324
Miao R, et al. (2008) EPR and Mössbauer spectroscopy of intact mitochondria isolated from Yah1p-depleted Saccharomyces cerevisiae. Biochemistry 47(37):9888-99 PMID:18717590
Stehling O, et al. (2008) Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis. Mol Cell Biol 28(17):5517-28 PMID:18573874
Mühlenhoff U, et al. (2007) The ISC [corrected] proteins Isa1 and Isa2 are required for the function but not for the de novo synthesis of the Fe/S clusters of biotin synthase in Saccharomyces cerevisiae. Eukaryot Cell 6(3):495-504 PMID:17259550
Netz DJ, et al. (2007) The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol. Nat Chem Biol 3(5):278-86 PMID:17401378
Srinivasan V, et al. (2007) Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis. Structure 15(10):1246-57 PMID:17937914
Biederbick A, et al. (2006) Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation. Mol Cell Biol 26(15):5675-87 PMID:16847322
Dutkiewicz R, et al. (2006) The Hsp70 chaperone Ssq1p is dispensable for iron-sulfur cluster formation on the scaffold protein Isu1p. J Biol Chem 281(12):7801-8 PMID:16431909
Kuhnke G, et al. (2006) Stimulation of the ATPase activity of the yeast mitochondrial ABC transporter Atm1p by thiol compounds. Mol Membr Biol 23(2):173-84 PMID:16754360
Lill R, et al. (2006) Mechanisms of iron-sulfur protein maturation in mitochondria, cytosol and nucleus of eukaryotes. Biochim Biophys Acta 1763(7):652-67 PMID:16843540
Ojeda L, et al. (2006) Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae. J Biol Chem 281(26):17661-9 PMID:16648636
Wiedemann N, et al. (2006) Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J 25(1):184-95 PMID:16341089
Yang M, et al. (2006) The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2. EMBO J 25(8):1775-83 PMID:16601688
Balk J, et al. (2005) The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly. Mol Cell Biol 25(24):10833-41 PMID:16314508
Balk J, et al. (2005) Nar1p, a conserved eukaryotic protein with similarity to Fe-only hydrogenases, functions in cytosolic iron-sulphur protein biogenesis. Biochem Soc Trans 33(Pt 1):86-9 PMID:15667273
Hausmann A, et al. (2005) The eukaryotic P loop NTPase Nbp35: an essential component of the cytosolic and nuclear iron-sulfur protein assembly machinery. Proc Natl Acad Sci U S A 102(9):3266-71 PMID:15728363
Kispal G, et al. (2005) Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria. EMBO J 24(3):589-98 PMID:15660134
Rutherford JC, et al. (2005) Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis. J Biol Chem 280(11):10135-40 PMID:15649888
Balk J, et al. (2004) The hydrogenase-like Nar1p is essential for maturation of cytosolic and nuclear iron-sulphur proteins. EMBO J 23(10):2105-15 PMID:15103330
Gerber J, et al. (2004) The yeast scaffold proteins Isu1p and Isu2p are required inside mitochondria for maturation of cytosolic Fe/S proteins. Mol Cell Biol 24(11):4848-57 PMID:15143178
Lange H, et al. (2004) The heme synthesis defect of mutants impaired in mitochondrial iron-sulfur protein biogenesis is caused by reversible inhibition of ferrochelatase. J Biol Chem 279(28):29101-8 PMID:15128732
Mühlenhoff U, et al. (2004) Functional characterization of the eukaryotic cysteine desulfurase Nfs1p from Saccharomyces cerevisiae. J Biol Chem 279(35):36906-15 PMID:15220327
Gerber J, et al. (2003) An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1. EMBO Rep 4(9):906-11 PMID:12947415
Mühlenhoff U, et al. (2003) A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions. J Biol Chem 278(42):40612-20 PMID:12902335
Mühlenhoff U, et al. (2003) Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p. EMBO J 22(18):4815-25 PMID:12970193
Mühlenhoff U, et al. (2002) Characterization of iron-sulfur protein assembly in isolated mitochondria. A requirement for ATP, NADH, and reduced iron. J Biol Chem 277(33):29810-6 PMID:12065597
Mühlenhoff U, et al. (2002) The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins. Hum Mol Genet 11(17):2025-36 PMID:12165564
Diekert K, et al. (2001) Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane. EMBO J 20(20):5626-35 PMID:11598006
Diekert K, et al. (2001) Isolation and subfractionation of mitochondria from the yeast Saccharomyces cerevisiae. Methods Cell Biol 65:37-51 PMID:11381604
Gerber J, et al. (2001) Yeast ERV2p is the first microsomal FAD-linked sulfhydryl oxidase of the Erv1p/Alrp protein family. J Biol Chem 276(26):23486-91 PMID:11313344
Kushnir S, et al. (2001) A mutation of the mitochondrial ABC transporter Sta1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik. Plant Cell 13(1):89-100 PMID:11158531
Lange H, et al. (2001) An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins. EMBO Rep 2(8):715-20 PMID:11493598
Prohl C, et al. (2001) The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix. Mol Cell Biol 21(4):1089-97 PMID:11158296
Sturtz LA, et al. (2001) A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage. J Biol Chem 276(41):38084-9 PMID:11500508
Bekri S, et al. (2000) Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation. Blood 96(9):3256-64 PMID:11050011
Kaut A, et al. (2000) Isa1p is a component of the mitochondrial machinery for maturation of cellular iron-sulfur proteins and requires conserved cysteine residues for function. J Biol Chem 275(21):15955-61 PMID:10748136
Lange H, et al. (2000) A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins. Proc Natl Acad Sci U S A 97(3):1050-5 PMID:10655482
Pelzer W, et al. (2000) Mitochondrial Isa2p plays a crucial role in the maturation of cellular iron-sulfur proteins. FEBS Lett 476(3):134-9 PMID:10913600
Diekert K, et al. (1999) An internal targeting signal directing proteins into the mitochondrial intermembrane space. Proc Natl Acad Sci U S A 96(21):11752-7 PMID:10518522
Grad LI, et al. (1999) Inactivation of the Neurospora crassa mitochondrial outer membrane protein TOM70 by repeat-induced point mutation (RIP) causes defects in mitochondrial protein import and morphology. Curr Genet 36(3):137-46 PMID:10501936
Kispal G, et al. (1999) The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins. EMBO J 18(14):3981-9 PMID:10406803
Csere P, et al. (1998) Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p. FEBS Lett 441(2):266-70 PMID:9883897
Künkele KP, et al. (1998) The isolated complex of the translocase of the outer membrane of mitochondria. Characterization of the cation-selective and voltage-gated preprotein-conducting pore. J Biol Chem 273(47):31032-9 PMID:9813001
Nargang FE, et al. (1998) Role of the negative charges in the cytosolic domain of TOM22 in the import of precursor proteins into mitochondria. Mol Cell Biol 18(6):3173-81 PMID:9584158
Rapaport D, et al. (1998) cis and trans sites of the TOM complex of mitochondria in unfolding and initial translocation of preproteins. J Biol Chem 273(15):8806-13 PMID:9535859
Rapaport D, et al. (1998) Dynamics of the TOM complex of mitochondria during binding and translocation of preproteins. Mol Cell Biol 18(9):5256-62 PMID:9710610
Court DA, et al. (1996) Role of the intermembrane-space domain of the preprotein receptor Tom22 in protein import into mitochondria. Mol Cell Biol 16(8):4035-42 PMID:8754801
Steiner H, et al. (1996) Heme binding to a conserved Cys-Pro-Val motif is crucial for the catalytic function of mitochondrial heme lyases. J Biol Chem 271(51):32605-11 PMID:8955088
Brunner M, et al. (1995) Dissection of protein translocation across the mitochondrial outer and inner membranes. Cold Spring Harb Symp Quant Biol 60:619-27 PMID:8824435
Schlenstedt G, et al. (1995) A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s. J Cell Biol 129(4):979-88 PMID:7744969
Steiner H, et al. (1995) Biogenesis of mitochondrial heme lyases in yeast. Import and folding in the intermembrane space. J Biol Chem 270(39):22842-9 PMID:7559417