Reference: Paul VD and Lill R (2014) SnapShot: eukaryotic Fe-S protein biogenesis. Cell Metab 20(2):384-384.e1

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Abstract


Iron-sulfur (Fe-S) clusters are essential protein cofactors involved in functions ranging from electron transport and enzyme processes to DNA replication, DNA repair, transcription, and translation. The synthesis of Fe-S clusters and their subsequent insertion into apoproteins is a conserved process involving some 30 proteins. This SnapShot details insights into the molecular mechanism of Fe-S protein biogenesis conserved from yeast to human cells.

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Journal Article
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Paul VD, Lill R
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