McLean S, et al. (2024) Molecular mechanisms of genotype-dependent lifespan variation mediated by caloric restriction: insight from wild yeast isolates. Front Aging 5:1408160 PMID:39055969
Phua CZJ, et al. (2023) Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites, and pathways that regulate lifespan. Geroscience 45(4):2161-2178 PMID:37086368
Patnaik PK, et al. (2022) Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function. Cell Rep 40(3):111113 PMID:35858543
Chen KL, et al. (2020) Loss of vacuolar acidity results in iron-sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae. Geroscience 42(2):749-764 PMID:31975050
Crane MM, et al. (2020) Trajectories of Aging: How Systems Biology in Yeast Can Illuminate Mechanisms of Personalized Aging. Proteomics 20(5-6):e1800420 PMID:31385433
Maitra N, et al. (2020) Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity. Elife 9 PMID:32432546
Mouton SN, et al. (2020) A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast. Elife 9 PMID:32990592
Zou K, et al. (2020) Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span. Sci Adv 6(32):eaba1306 PMID:32821821
Crane MM, et al. (2019) Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast. Transl Med Aging 3:104-108 PMID:32190787
Lee MB, et al. (2019) Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes. Proc Natl Acad Sci U S A 116(8):3062-3071 PMID:30718408
Sanchez JC, et al. (2019) Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of Saccharomyces cerevisiae. Genetics 213(1):229-249 PMID:31292210
Beaupere C, et al. (2018) Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A 115(38):9586-9591 PMID:30185560
Lee MB, et al. (2017) A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae. Geroscience 39(4):419-428 PMID:28707282
Cui HJ, et al. (2015) PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae. Age (Dordr) 37(3):9788 PMID:25936926
Jafari G, et al. (2015) Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein. Proc Natl Acad Sci U S A 112(45):E6148-57 PMID:26504246
McCormick MA, et al. (2015) A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metab 22(5):895-906 PMID:26456335
Yang J, et al. (2015) Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry. Proc Natl Acad Sci U S A 112(38):11977-82 PMID:26351681
He C, et al. (2014) Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. PLoS Genet 10(12):e1004860 PMID:25521617
Labunskyy VM, et al. (2014) Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. PLoS Genet 10(1):e1004019 PMID:24391512
Wasko BM and Kaeberlein M (2014) Yeast replicative aging: a paradigm for defining conserved longevity interventions. FEMS Yeast Res 14(1):148-59 PMID:24119093
Zhao W, et al. (2014) Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. Mech Ageing Dev 138:53-8 PMID:24486555
Delaney JR, et al. (2013) Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae. Exp Gerontol 48(10):1006-13 PMID:23235143
Delaney JR, et al. (2013) Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell 12(1):156-66 PMID:23167605
Kwan EX, et al. (2013) A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS Genet 9(3):e1003329 PMID:23505383
O'Leary MN, et al. (2013) The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1. PLoS Genet 9(8):e1003708 PMID:23990801
Murakami C, et al. (2012) pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast. Cell Cycle 11(16):3087-96 PMID:22871733
Schleit J, et al. (2012) Yeast as a model to understand the interaction between genotype and the response to calorie restriction. FEBS Lett 586(18):2868-73 PMID:22828279
Delaney JR, et al. (2011) Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell Cycle 10(1):156-65 PMID:21191185
Murakami CJ, et al. (2011) Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast. PLoS One 6(9):e24530 PMID:21949725
Olsen B, et al. (2010) YODA: software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast. BMC Bioinformatics 11:141 PMID:20298554
Managbanag JR, et al. (2008) Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. PLoS One 3(11):e3802 PMID:19030232
Murakami CJ, et al. (2008) A method for high-throughput quantitative analysis of yeast chronological life span. J Gerontol A Biol Sci Med Sci 63(2):113-21 PMID:18314444
Smith ED, et al. (2008) Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res 18(4):564-70 PMID:18340043
Lockshon D, et al. (2007) The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics 175(1):77-91 PMID:17151231
Tsuchiya M, et al. (2006) Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. Aging Cell 5(6):505-14 PMID:17129213
Kaeberlein M, et al. (2005) Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev 126(4):491-504 PMID:15722108
Armstrong CM, et al. (2002) Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Mol Biol Cell 13(4):1427-38 PMID:11950950
Kaeberlein M and Guarente L (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160(1):83-95 PMID:11805047
Kaeberlein M, et al. (2002) High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol Cell Biol 22(22):8056-66 PMID:12391171
McVey M, et al. (2001) The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. Genetics 157(4):1531-42 PMID:11290710
Imai S, et al. (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403(6771):795-800 PMID:10693811
Defossez PA, et al. (1999) Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol Cell 3(4):447-55 PMID:10230397
Kaeberlein M, et al. (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13(19):2570-80 PMID:10521401