Caligaris M, et al. (2023) The Yeast Protein Kinase Sch9 Functions as a Central Nutrient-Responsive Hub That Calibrates Metabolic and Stress-Related Responses. J Fungi (Basel) 9(8) PMID:37623558
Grziwa S, et al. (2023) Yck3 casein kinase-mediated phosphorylation determines Ivy1 localization and function at endosomes and the vacuole. J Cell Sci 136(12) PMID:37259913
Gao J, et al. (2022) The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity. J Cell Biol 221(5) PMID:35404387
Dokládal L, et al. (2021) Phosphoproteomic responses of TORC1 target kinases reveal discrete and convergent mechanisms that orchestrate the quiescence program in yeast. Cell Rep 37(13):110149 PMID:34965436
Tate JJ, et al. (2021) N- and C-terminal Gln3-Tor1 interaction sites: one acting negatively and the other positively to regulate nuclear Gln3 localization. Genetics 217(4) PMID:33857304
Hatakeyama R and De Virgilio C (2019) A spatially and functionally distinct pool of TORC1 defines signaling endosomes in yeast. Autophagy 15(5):915-916 PMID:30732525
Zhang T, et al. (2019) Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases. Sci Adv 5(9):eaax8164 PMID:31579828
Fruhmann G, et al. (2018) The Impact of ESCRT on Aβ1-42 Induced Membrane Lesions in a Yeast Model for Alzheimer's Disease. Front Mol Neurosci 11:406 PMID:30455629
Moreno-Torres M, et al. (2017) TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1. Cell Discov 3:17012 PMID:28496991
Péli-Gulli MP, et al. (2017) Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals. Cell Rep 20(2):281-288 PMID:28700931
Wilms T, et al. (2017) The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability. PLoS Genet 13(6):e1006835 PMID:28604780
Powis K and De Virgilio C (2016) Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling. Cell Discov 2:15049 PMID:27462445
Moreno-Torres M, et al. (2015) TORC1 controls G1-S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway. Nat Commun 6:8256 PMID:26356805
Numrich J, et al. (2015) The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis. J Cell Sci 128(13):2278-92 PMID:25999476
Powis K, et al. (2015) Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling. Cell Res 25(9):1043-59 PMID:26206314
Péli-Gulli MP, et al. (2015) Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2. Cell Rep 13(1):1-7 PMID:26387955
Dubots E, et al. (2014) TORC1 regulates Pah1 phosphatidate phosphatase activity via the Nem1/Spo7 protein phosphatase complex. PLoS One 9(8):e104194 PMID:25117580
Bontron S, et al. (2013) Yeast endosulfines control entry into quiescence and chronological life span by inhibiting protein phosphatase 2A. Cell Rep 3(1):16-22 PMID:23273919
Panchaud N, et al. (2013) SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation. Cell Cycle 12(18):2948-52 PMID:23974112
Panchaud N, et al. (2013) Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1. Sci Signal 6(277):ra42 PMID:23716719
Talarek N, et al. (2013) Quantification of mRNA stability of stress-responsive yeast genes following conditional excision of open reading frames. RNA Biol 10(8):1299-308 PMID:23792549
Chen J, et al. (2012) Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry. ACS Chem Biol 7(4):715-22 PMID:22260433
Zhang T, et al. (2012) Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1. Structure 20(12):2151-60 PMID:23123112
Luo X, et al. (2011) Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs. RNA Biol 8(1):14-7 PMID:21289492
Mok J, et al. (2010) Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal 3(109):ra12 PMID:20159853
Smets B, et al. (2010) Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae. Curr Genet 56(1):1-32 PMID:20054690
Talarek N, et al. (2010) Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway. Mol Cell 38(3):345-55 PMID:20471941
Zabrocki P, et al. (2008) Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson. Biochim Biophys Acta 1783(10):1767-80 PMID:18634833
De Filippi L, et al. (2007) Membrane stress is coupled to a rapid translational control of gene expression in chlorpromazine-treated cells. Curr Genet 52(3-4):171-85 PMID:17710403
Mulder KW, et al. (2007) Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae. Genetics 176(1):181-92 PMID:17513889
Cameroni E, et al. (2006) Phosphatidylinositol 4-phosphate is required for translation initiation in Saccharomyces cerevisiae. J Biol Chem 281(50):38139-49 PMID:17005563
Lenssen E, et al. (2005) The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution. Mol Cell Biol 25(1):488-98 PMID:15601868
Roosen J, et al. (2005) PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability. Mol Microbiol 55(3):862-80 PMID:15661010
Cameroni E, et al. (2004) The novel yeast PAS kinase Rim 15 orchestrates G0-associated antioxidant defense mechanisms. Cell Cycle 3(4):462-8 PMID:15300954
Pedruzzi I, et al. (2003) TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0. Mol Cell 12(6):1607-13 PMID:14690612
Lee PR, et al. (2002) Bni5p, a septin-interacting protein, is required for normal septin function and cytokinesis in Saccharomyces cerevisiae. Mol Cell Biol 22(19):6906-20 PMID:12215547
Lenssen E, et al. (2002) Saccharomyces cerevisiae Ccr4-not complex contributes to the control of Msn2p-dependent transcription by the Ras/cAMP pathway. Mol Microbiol 43(4):1023-37 PMID:11929548
Pedruzzi I, et al. (2000) Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1. EMBO J 19(11):2569-79 PMID:10835355
Reinders A, et al. (1999) The thermophilic yeast Hansenula polymorpha does not require trehalose synthesis for growth at high temperatures but does for normal acquisition of thermotolerance. J Bacteriol 181(15):4665-8 PMID:10419968
Bell W, et al. (1998) Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex. J Biol Chem 273(50):33311-9 PMID:9837904
Reinders A, et al. (1998) Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase. Genes Dev 12(18):2943-55 PMID:9744870
DeMarini DJ, et al. (1997) A septin-based hierarchy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall. J Cell Biol 139(1):75-93 PMID:9314530
Reinders A, et al. (1997) Structural analysis of the subunits of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae and their function during heat shock. Mol Microbiol 24(4):687-95 PMID:9194697
Ribeiro MJ, et al. (1997) Trehalose synthesis is important for the acquisition of thermotolerance in Schizosaccharomyces pombe. Mol Microbiol 25(3):571-81 PMID:9302019
De Virgilio C, et al. (1996) SPR28, a sixth member of the septin gene family in Saccharomyces cerevisiae that is expressed specifically in sporulating cells. Microbiology (Reading) 142 ( Pt 10):2897-905 PMID:8885406
Cvrcková F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 PMID:7649470
Stevenson BJ, et al. (1995) Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae. Genes Dev 9(23):2949-63 PMID:7498791
De Virgilio C, et al. (1994) The role of trehalose synthesis for the acquisition of thermotolerance in yeast. I. Genetic evidence that trehalose is a thermoprotectant. Eur J Biochem 219(1-2):179-86 PMID:8306984
Hottiger T, et al. (1994) The role of trehalose synthesis for the acquisition of thermotolerance in yeast. II. Physiological concentrations of trehalose increase the thermal stability of proteins in vitro. Eur J Biochem 219(1-2):187-93 PMID:8306985
De Virgilio C, et al. (1993) Disruption of TPS2, the gene encoding the 100-kDa subunit of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae, causes accumulation of trehalose-6-phosphate and loss of trehalose-6-phosphate phosphatase activity. Eur J Biochem 212(2):315-23 PMID:8444170
De Virgilio C, et al. (1992) Cloning and disruption of a gene required for growth on acetate but not on ethanol: the acetyl-coenzyme A synthetase gene of Saccharomyces cerevisiae. Yeast 8(12):1043-51 PMID:1363452
Hottiger T, et al. (1992) The 70-kilodalton heat-shock proteins of the SSA subfamily negatively modulate heat-shock-induced accumulation of trehalose and promote recovery from heat stress in the yeast, Saccharomyces cerevisiae. Eur J Biochem 210(1):125-32 PMID:1446665
De Virgilio C, et al. (1991) Acquisition of thermotolerance in Saccharomyces cerevisiae without heat shock protein hsp 104 and in the absence of protein synthesis. FEBS Lett 288(1-2):86-90 PMID:1831771
De Virgilio C, et al. (1991) A method to study the rapid phosphorylation-related modulation of neutral trehalase activity by temperature shifts in yeast. FEBS Lett 291(2):355-8 PMID:1936286