Reference: Orban DP and Klionsky DJ (2014) CUET-ting edge research. Autophagy 10(12):2097-8

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Abstract


Ubiquitinated aggregates of aggregation-prone proteins are a common feature in many neurodegenerative diseases. In mammalian cells receptor proteins that deliver these aggregates to the lysosome for degradation via selective autophagy are well established. The common feature of these receptors, namely SQSTM1/p62 and NBR1, is the ability to bind ubiquitin and LC3, thus connecting the ubiquitin pathway and autophagy. However, it remained unknown if a counterpart of this pathway exists in yeast. A recent study identified the CUET-proteins as a new class of conserved ubiquitin-Atg8 receptors.

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Comment | Journal Article | Research Support, N.I.H., Extramural
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Orban DP, Klionsky DJ
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