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Reference: Moura G, et al. (2005) Comparative context analysis of codon pairs on an ORFeome scale. Genome Biol 6(3):R28

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Abstract

Codon context is an important feature of gene primary structure that modulates mRNA decoding accuracy. We have developed an analytical software package and a graphical interface for comparative codon context analysis of all the open reading frames in a genome (the ORFeome). Using the complete ORFeome sequences of Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida albicans and Escherichia coli, we show that this methodology permits large-scale codon context comparisons and provides new insight on the rules that govern the evolution of codon-pair context.

Reference Type
Comparative Study | Evaluation Study | Journal Article | Research Support, Non-U.S. Gov't
Authors
Moura G, Pinheiro M, Silva R, Miranda I, Afreixo V, Dias G, Freitas A, Oliveira JL, Santos MA
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