Reference: Seufert W and Jentsch S (1992) In vivo function of the proteasome in the ubiquitin pathway. EMBO J 11(8):3077-80

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Abstract


A major eukaryotic proteolytic system is known to require the covalent attachment of ubiquitin to substrates prior to their degradation, yet the proteinase involved remains poorly defined. The proteasome, a large conserved multi-subunit protein complex of the cytosol and the nucleus, has been implicated in a variety of cellular functions. It is shown here that a yeast mutant with a defective proteasome fails to degrade proteins which are subject to ubiquitin-dependent proteolysis in wild-type cells. Thus, the proteasome is part of the ubiquitin system and mediates the degradation of ubiquitin-protein conjugates in vivo.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Seufert W, Jentsch S
Additional Lit For
PRE1 | pre1-1