The UGA35 gene of Saccharomyces cerevisiae (also called DURL) encodes a positive regulator of the expression of structural genes involved in 4-aminobutyric acid (GABA) and urea catabolisms. The UGA35 gene has been cloned by complementation of function and identified by chromosomal gene replacement. The sequence of this regulatory gene and its flanking regions has been established. Our data reveal an open reading frame of 2892 nt, corresponding to 964 amino acids (aa). The deduced UGA35 aa sequence shares several similarities with that of other regulatory proteins, suggesting that the UGA35 gene encodes a DNA-binding transcriptional activator. We also show that UGA35 and the DAL81 regulatory gene controlling allantoin and urea catabolisms are one and the same gene. This means that the same factor is required for specific induction of three distinct catabolic pathways, namely those involved in GABA, urea and allantoin utilization as nitrogen sources.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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