Reference: Sicheri F, et al. (1997) Crystal structure of the Src family tyrosine kinase Hck. Nature 385(6617):602-9

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Abstract


The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

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Journal Article
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Sicheri F, Moarefi I, Kuriyan J
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