PDC1 / YLR044C Overview

Standard Name
PDC1 1 2
Systematic Name
Feature Type
ORF , Verified
Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo; protein tyrosine nitration on Tyr157 or Tyr344 inhibits activity and impairs fermentation 1 3 4 5 6 7 9 10 11
Name Description
Pyruvate DeCarboxylase 8
Comparative Info
Sequence Details


The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

PDC1 is located on the right arm of chromosome XII between TRX1 thioredoxin and STU2 microtubule polymerase; coding sequence is 1692 nucleotides long with 8 SNPSs, 4 of which lead to amino acid polymorphisms
Protein Details


Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Pdc1p is 563 amino acids long, longer-lived, extremely high in abundance; carbamoylated on C221 and C222, methylated on R161, sumoylated on 11 lysines, acetylated on 15 lysines, ubiquitinylated on 17 lysines, succinylated on 17 lysines, phosphorylated on 28 residues
Length (a.a.)
Mol. Weight (Da)
Isoelectric Point
Median Abundance (molecules/cell)
581219 +/- 457355
Half-life (hr)


Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.

View all PDC1 alleles in SGD search

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

Pyruvate decarboxylase involved in amino acid catabolism and the fermentation of glucose to ethanol; localizes to both the nucleus and the cytosol

View computational annotations

Molecular Function

Manually Curated

Cellular Component

Manually Curated


Phenotype Details


Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Non-essential gene; null mutant shows slow growth rate; in large-scale studies, null mutant exhibits decreased competitive fitness, heat sensitivity, and altered resistance to various chemicals
Interaction Details


Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

Pdc1p interacts physically with proteins involved in translation, PDC1 interacts genetically with genes involved in transcription

333 total interactions for 281 unique genes

Physical Interactions

  • Affinity Capture-MS: 180
  • Affinity Capture-RNA: 15
  • Biochemical Activity: 2
  • Co-crystal Structure: 3
  • Co-localization: 1
  • PCA: 3
  • Proximity Label-MS: 2
  • Two-hybrid: 3

Genetic Interactions

  • Dosage Rescue: 3
  • Negative Genetic: 92
  • Phenotypic Enhancement: 7
  • Positive Genetic: 12
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2
Regulation Details


The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

PDC1 transcription is downregulated by Ert1p during gluconeogenesis; PDC1 transcription is upregulated by Pdc2p in response to vitamin B1 starvation and by Znf1p during glycolytic fermentation
Expression Details


Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Summary Paragraph

A summary of the locus, written by SGD Biocurators following a thorough review of the literature. Links to gene names and curated GO terms are included within the Summary Paragraphs.

Last Updated: 2007-06-01

Literature Details


All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.