Literature Help
REP1 / R0020C Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Girard F, et al. (2025) Parasitic plasmids are anchored to inactive regions of eukaryotic chromosomes through a nucleosome signal. EMBO J 44(7):2134-2156 PMID:40016420
- Ma CH, et al. (2023) The selfish yeast plasmid exploits a SWI/SNF-type chromatin remodeling complex for hitchhiking on chromosomes and ensuring high-fidelity propagation. PLoS Genet 19(10):e1010986 PMID:37812641
- Mereshchuk A, et al. (2022) The yeast 2-micron plasmid Rep2 protein has Rep1-independent partitioning function. Nucleic Acids Res 50(18):10571-10585 PMID:36156142
- Sharma D, et al. (2022) A new method for determining ribosomal DNA copy number shows differences between Saccharomyces cerevisiae populations. Genomics 114(4):110430 PMID:35830947
- Kumar D, et al. (2021) The selfish yeast plasmid utilizes the condensin complex and condensed chromatin for faithful partitioning. PLoS Genet 17(7):e1009660 PMID:34270553
- McQuaid ME, et al. (2019) DNA sequence elements required for partitioning competence of the Saccharomyces cerevisiae 2-micron plasmid STB locus. Nucleic Acids Res 47(2):716-728 PMID:30445476
- A Rizvi SM, et al. (2017) The 2-μm plasmid encoded protein Raf1 regulates both stability and copy number of the plasmid by blocking the formation of the Rep1-Rep2 repressor complex. Nucleic Acids Res 45(12):7167-7179 PMID:28472368
- Liu YT, et al. (2016) Replication-dependent and independent mechanisms for the chromosome-coupled persistence of a selfish genome. Nucleic Acids Res 44(17):8302-23 PMID:27492289
- Jayaram M, et al. (2013) Topological similarity between the 2μm plasmid partitioning locus and the budding yeast centromere: evidence for a common evolutionary origin? Biochem Soc Trans 41(2):501-7 PMID:23514143
- Pinder JB, et al. (2013) Deficient sumoylation of yeast 2-micron plasmid proteins Rep1 and Rep2 associated with their loss from the plasmid-partitioning locus and impaired plasmid inheritance. PLoS One 8(3):e60384 PMID:23555963
- Huang CC, et al. (2011) Cse4 (CenH3) association with the Saccharomyces cerevisiae plasmid partitioning locus in its native and chromosomally integrated states: implications in centromere evolution. Mol Cell Biol 31(5):1030-40 PMID:21173161
- Jayaram M, et al. (2004) Site-specific recombination and partitioning systems in the stable high copy propagation of the 2-micron yeast plasmid. Prog Nucleic Acid Res Mol Biol 77:127-72 PMID:15196892
- Yang XM, et al. (2004) Mutations in a partitioning protein and altered chromatin structure at the partitioning locus prevent cohesin recruitment by the Saccharomyces cerevisiae plasmid and cause plasmid missegregation. Mol Cell Biol 24(12):5290-303 PMID:15169893
- Mehta S, et al. (2002) The 2 micron plasmid purloins the yeast cohesin complex: a mechanism for coupling plasmid partitioning and chromosome segregation? J Cell Biol 158(4):625-37 PMID:12177044
- Wong MC, et al. (2002) RSC2, encoding a component of the RSC nucleosome remodeling complex, is essential for 2 microm plasmid maintenance in Saccharomyces cerevisiae. Mol Cell Biol 22(12):4218-29 PMID:12024034
- Sengupta A, et al. (2001) Functional domains of yeast plasmid-encoded Rep proteins. J Bacteriol 183(7):2306-15 PMID:11244071
- Velmurugan S, et al. (2000) Partitioning of the 2-microm circle plasmid of Saccharomyces cerevisiae. Functional coordination with chromosome segregation and plasmid-encoded rep protein distribution. J Cell Biol 149(3):553-66 PMID:10791970
- Scott-Drew S and Murray JA (1998) Localisation and interaction of the protein components of the yeast 2 mu circle plasmid partitioning system suggest a mechanism for plasmid inheritance. J Cell Sci 111 ( Pt 13):1779-89 PMID:9625741
- Velmurugan S, et al. (1998) The 2 micrometer plasmid stability system: analyses of the interactions among plasmid- and host-encoded components. Mol Cell Biol 18(12):7466-77 PMID:9819432
- Ahn YT, et al. (1997) The 2microm-plasmid-encoded Rep1 and Rep2 proteins interact with each other and colocalize to the Saccharomyces cerevisiae nucleus. J Bacteriol 179(23):7497-506 PMID:9393716
- Hadfield C, et al. (1995) Protein binding interactions at the STB locus of the yeast 2 microns plasmid. Nucleic Acids Res 23(6):995-1002 PMID:7731815
- Van der Sand ST, et al. (1995) The maintenance of self-replicating plasmids in Saccharomyces cerevisiae: mathematical modelling, computer simulations and experimental tests. Yeast 11(7):641-58 PMID:7483837
- Rank GH, et al. (1994) Evidence for Darwinian selection of the 2-micron plasmid STB locus in Saccharomyces cerevisiae. Genome 37(1):12-8 PMID:8181732
- Gartenberg MR and Wang JC (1993) Identification of barriers to rotation of DNA segments in yeast from the topology of DNA rings excised by an inducible site-specific recombinase. Proc Natl Acad Sci U S A 90(22):10514-8 PMID:8248138
- Xiao W, et al. (1991) Sequence diversity of yeast 2 microns RAF gene and its co-evolution with STB and REP1. Gene 101(1):75-80 PMID:1676387
- Xiao W, et al. (1991) Evidence for cis- and trans-acting element coevolution of the 2-microns circle genome in Saccharomyces cerevisiae. J Mol Evol 32(2):145-52 PMID:1672551
- Neuville P, et al. (1990) Heterogeneity among the 2 microns plasmids in Saccharomyces cerevisiae: a new sequence for the REP1 gene. Gene 89(1):139-44 PMID:2197179
- Dobson MJ, et al. (1988) Reconstruction of the yeast 2 micron plasmid partitioning mechanism. Nucleic Acids Res 16(14B):7103-17 PMID:3043377
- Som T, et al. (1988) Autoregulation of 2 micron circle gene expression provides a model for maintenance of stable plasmid copy levels. Cell 52(1):27-37 PMID:2449970
- Veit BE and Fangman WL (1988) Copy number and partition of the Saccharomyces cerevisiae 2 micron plasmid controlled by transcription regulators. Mol Cell Biol 8(11):4949-57 PMID:3062375
- Murray JA, et al. (1987) Antagonistic controls regulate copy number of the yeast 2 mu plasmid. EMBO J 6(13):4205-12 PMID:2832156
- Reynolds AE, et al. (1987) Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae. Mol Cell Biol 7(10):3566-73 PMID:3316982
- Wu LC, et al. (1987) A yeast plasmid partitioning protein is a karyoskeletal component. J Biol Chem 262(2):883-91 PMID:3542994
- Jayaram M, et al. (1986) Inducible expression of REP1 causes inducible expression of the 2 micron circle stability system. Curr Genet 11(2):85-91 PMID:2834084
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
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Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Wang Y, et al. (2023) Quantitative Proteomics-Based Substrate Screening Revealed Cyclophilin Stabilization Regulated by Deubiquitinase Ubp7. J Proteome Res 22(7):2281-2292 PMID:37341107
- Zhou J, et al. (2022) Exogenous artificial DNA forms chromatin structure with active transcription in yeast. Sci China Life Sci 65(5):851-860 PMID:34970711
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Yang J, et al. (2021) Harnessing the Endogenous 2μ Plasmid of Saccharomyces cerevisiae for Pathway Construction. Front Microbiol 12:679665 PMID:34220765
- McQuaid ME, et al. (2017) The yeast 2-μm plasmid Raf protein contributes to plasmid inheritance by stabilizing the Rep1 and Rep2 partitioning proteins. Nucleic Acids Res 45(18):10518-10533 PMID:29048592
- Wang K, et al. (2015) Proteomic analysis of protein methylation in the yeast Saccharomyces cerevisiae. J Proteomics 114:226-33 PMID:25109467
- Liu YT, et al. (2013) Co-segregation of yeast plasmid sisters under monopolin-directed mitosis suggests association of plasmid sisters with sister chromatids. Nucleic Acids Res 41(7):4144-58 PMID:23423352
- Ma CH, et al. (2013) Temporal sequence and cell cycle cues in the assembly of host factors at the yeast 2 micron plasmid partitioning locus. Nucleic Acids Res 41(4):2340-53 PMID:23275556
- Cui H, et al. (2009) The selfish yeast plasmid uses the nuclear motor Kip1p but not Cin8p for its localization and equal segregation. J Cell Biol 185(2):251-64 PMID:19364922
- Ghosh SK, et al. (2007) Faithful segregation of the multicopy yeast plasmid through cohesin-mediated recognition of sisters. Proc Natl Acad Sci U S A 104(32):13034-9 PMID:17670945
- Hajra S, et al. (2006) The centromere-specific histone variant Cse4p (CENP-A) is essential for functional chromatin architecture at the yeast 2-microm circle partitioning locus and promotes equal plasmid segregation. J Cell Biol 174(6):779-90 PMID:16966420
- Dobson MJ, et al. (2005) The 2 microm plasmid causes cell death in Saccharomyces cerevisiae with a mutation in Ulp1 protease. Mol Cell Biol 25(10):4299-310 PMID:15870298
- Hallberg M, et al. (2004) Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid. Proc Natl Acad Sci U S A 101(10):3370-5 PMID:14988503
- Pereira-Leal JB, et al. (2003) Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface. Biochem Biophys Res Commun 301(1):92-7 PMID:12535645
- Scott-Drew S, et al. (2002) DNA plasmid transmission in yeast is associated with specific sub-nuclear localisation during cell division. Cell Biol Int 26(5):393-405 PMID:12095225
- Sleep D, et al. (2001) Yeast 2 microm plasmid copy number is elevated by a mutation in the nuclear gene UBC4. Yeast 18(5):403-21 PMID:11255249
- Xiao W and Rank GH (1996) The 2 micron plasmid of laboratory yeast strains is a type-1/type-2 hybrid. Yeast 12(8):809-13 PMID:8813767
- Fagrelius TJ, et al. (1987) Changes in the DNase I sensitivity of DNA sequences within the yeast 2 micron plasmid nucleoprotein complex effected by plasmid-encoded products. J Mol Biol 197(3):415-23 PMID:3441005
- Jayaram M, et al. (1985) Properties of REP3: a cis-acting locus required for stable propagation of the Saccharomyces cerevisiae plasmid 2 microns circle. Mol Cell Biol 5(9):2466-75 PMID:3915543
- Jayaram M, et al. (1983) The yeast plasmid 2mu circle encodes components required for its high copy propagation. Cell 34(1):95-104 PMID:6883512
- Dobson MJ, et al. (1980) Loss of 2 um DNA from Saccharomyces cerevisiae transformed with the chimaeric plasmid pJDB219. Curr Genet 2(3):201-5 PMID:24189910
- Gerbaud C and Guérineau M (1980) 2 μm plasmid copy number in different yeast strains and repartition of endogenous and 2 μm chimeric plasmids in transformed strains. Curr Genet 1(3):219-28 PMID:24189662
- Hartley JL and Donelson JE (1980) Nucleotide sequence of the yeast plasmid. Nature 286(5776):860-5 PMID:6251374
- McNeil JB, et al. (1980) High frequency recombination and the expression of genes cloned on chimeric yeast plasmids: Identification of a fragment of 2-μm circle essential for transformation. Curr Genet 2(1):17-251 PMID:24189719
- Thomas DY and James AP (1980) Transformation of Saccharomyces cerevisiae with plasmids containing fragments of yeast 2 μ DNA and a suppressor tRNA gene. Curr Genet 2(1):9-16 PMID:24189718
Reviews
No reviews curated.
Download References (.nbib)
- Hays M (2024) Genetic conflicts in budding yeast: The 2μ plasmid as a model selfish element. Semin Cell Dev Biol 161-162:31-41 PMID:38598944
- Kumar D and Ghosh SK (2024) Chromosome hitchhiking: a potential strategy adopted by the selfish yeast plasmids to ensure symmetric inheritance during cell division. Biochem Soc Trans 52(6):2359-2372 PMID:39670686
- Ruchala J, et al. (2020) Construction of advanced producers of first- and second-generation ethanol in Saccharomyces cerevisiae and selected species of non-conventional yeasts (Scheffersomyces stipitis, Ogataea polymorpha). J Ind Microbiol Biotechnol 47(1):109-132 PMID:31637550
- McQuaid ME, et al. (2019) Insights into the DNA sequence elements required for partitioning and copy number control of the yeast 2-micron plasmid. Curr Genet 65(4):887-892 PMID:30915516
- Sau S, et al. (2019) Hitchhiking on chromosomes: A persistence strategy shared by diverse selfish DNA elements. Plasmid 102:19-28 PMID:30726706
- Rizvi SMA, et al. (2018) The 2 micron plasmid: a selfish genetic element with an optimized survival strategy within Saccharomyces cerevisiae. Curr Genet 64(1):25-42 PMID:28597305
- Rowley PA (2017) The frenemies within: viruses, retrotransposons and plasmids that naturally infect Saccharomyces yeasts. Yeast 34(7):279-292 PMID:28387035
- Sau S, et al. (2015) Stable persistence of the yeast plasmid by hitchhiking on chromosomes during vegetative and germ-line divisions of host cells. Mob Genet Elements 5(2):1-8 PMID:26442178
- Bloom KS (2014) Centromeric heterochromatin: the primordial segregation machine. Annu Rev Genet 48:457-84 PMID:25251850
- Liu YT, et al. (2014) The partitioning and copy number control systems of the selfish yeast plasmid: an optimized molecular design for stable persistence in host cells. Microbiol Spectr 2(5) PMID:25541598
- Chan KM, et al. (2013) The 2 micron plasmid of Saccharomyces cerevisiae: a miniaturized selfish genome with optimized functional competence. Plasmid 70(1):2-17 PMID:23541845
- Jayaram M (2011) Association of a centromere specific nucleosome with the yeast plasmid partitioning locus: Implications beyond plasmid partitioning. Mob Genet Elements 1(3):203-207 PMID:22479687
- Malik HS and Henikoff S (2009) Major evolutionary transitions in centromere complexity. Cell 138(6):1067-82 PMID:19766562
- Ghosh SK, et al. (2006) Mechanisms for chromosome and plasmid segregation. Annu Rev Biochem 75:211-41 PMID:16756491
- Malik HS (2006) A hitchhiker's guide to survival finally makes CENs. J Cell Biol 174(6):747-9 PMID:16966417
- Papacs LA, et al. (2004) REP3-mediated silencing in Saccharomyces cerevisiae. Genetics 166(1):79-87 PMID:15020408
- Velmurugan S, et al. (2003) Stable propagation of 'selfish' genetic elements. J Biosci 28(5):623-36 PMID:14517366
- Davis L and Smith GR (2001) Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe. Proc Natl Acad Sci U S A 98(15):8395-402 PMID:11459981
- Broach JR and Volkert FC (1991) "Circular DNA Plasmids of Yeasts." Pp. 297-331 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Genome Dynamics, Protein Synthesis, and Energetics, edited by Broach JR, Jones EW and Pringle JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
- Futcher AB (1988) The 2 micron circle plasmid of Saccharomyces cerevisiae. Yeast 4(1):27-40 PMID:3059711
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Download References (.nbib)
- Ma CH, et al. (2023) The selfish yeast plasmid exploits a SWI/SNF-type chromatin remodeling complex for hitchhiking on chromosomes and ensuring high-fidelity propagation. PLoS Genet 19(10):e1010986 PMID:37812641
- A Rizvi SM, et al. (2017) The 2-μm plasmid encoded protein Raf1 regulates both stability and copy number of the plasmid by blocking the formation of the Rep1-Rep2 repressor complex. Nucleic Acids Res 45(12):7167-7179 PMID:28472368
- Liu YT, et al. (2016) Replication-dependent and independent mechanisms for the chromosome-coupled persistence of a selfish genome. Nucleic Acids Res 44(17):8302-23 PMID:27492289
- Pinder JB, et al. (2013) Deficient sumoylation of yeast 2-micron plasmid proteins Rep1 and Rep2 associated with their loss from the plasmid-partitioning locus and impaired plasmid inheritance. PLoS One 8(3):e60384 PMID:23555963
- Ahn YT, et al. (1997) The 2microm-plasmid-encoded Rep1 and Rep2 proteins interact with each other and colocalize to the Saccharomyces cerevisiae nucleus. J Bacteriol 179(23):7497-506 PMID:9393716
- Wu LC, et al. (1987) A yeast plasmid partitioning protein is a karyoskeletal component. J Biol Chem 262(2):883-91 PMID:3542994
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
Download References (.nbib)
- Leutert M, et al. (2023) The regulatory landscape of the yeast phosphoproteome. Nat Struct Mol Biol 30(11):1761-1773 PMID:37845410
- Bhagwat NR, et al. (2021) SUMO is a pervasive regulator of meiosis. Elife 10 PMID:33502312
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- MacGilvray ME, et al. (2020) Phosphoproteome Response to Dithiothreitol Reveals Unique Versus Shared Features of Saccharomyces cerevisiae Stress Responses. J Proteome Res 19(8):3405-3417 PMID:32597660
- Wang K, et al. (2015) Proteomic analysis of protein methylation in the yeast Saccharomyces cerevisiae. J Proteomics 114:226-33 PMID:25109467
- Swaney DL, et al. (2013) Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nat Methods 10(7):676-82 PMID:23749301