Phenotype Help

MCO6 / YJL127C-B Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

4 entries for 4 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
heat sensitivity: increased
classical genetics null
Allele: mco6-Δ
S288CMedia: non-fermentable carbon source
Temperature: elevated temperature, 39 °C
Details: growth defect at elevated temperature that is especially pronounced on non-fermentable glycerol-containing medium
Busto JV, et al. (2024) PMID:38377000
protein/peptide accumulation: decreased
Reporter: Mdm10p
classical genetics null
Allele: mco6-Δ
S288CMedia: non-fermentable carbon source
Temperature: elevated temperature, 39 °C
Details: reduction in the levels of Mdm10p at elevated temperature on non-fermentable glycerol-containing medium; indicative of decreased protein stability
Busto JV, et al. (2024) PMID:38377000
toxin resistance: increased
systematic mutation set

DAmP assay: decreased abundance by mRNA perturbation

repressibleS288CDetails: TDP-43; human RNA-binding protein that forms inclusions and aggregates in ALS disease models
Armakola M, et al. (2012) PMID:23104007
viable
systematic mutation setnull
Allele: mco6-Δ
S288CKastenmayer JP, et al. (2006) PMID:16510898
Showing 1 to 4 of 4 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.

4

Resources