Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
22 entries for 15 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| chemical compound accumulation: abnormal | systematic mutation set | null Allele: tim8-Δ | S288C | alpha-amino acid | Details: Significantly altered free amino acid profile (X^2- test adjusted p < 0.01), showing 4 simultaneous amino acid changes (Z-test, adjusted p < 0.01) | Mülleder M, et al. (2016) PMID:27693354 |
| chemical compound accumulation: decreased | systematic mutation set | null Allele: tim8-Δ | S288C | tyrosine | Mülleder M, et al. (2016) PMID:27693354 | |
| chemical compound accumulation: decreased | classical genetics | null Allele: tim8-Δ | S288C | reactive oxygen species | Treatment: tunicamycin, 1.5 μM Details: reduced intracellular ROS level in the null mutant compared to wt in cells treated with ER stress inducer tunicamycin | Tang D, et al. (2025) PMID:40001574 |
| chemical compound accumulation: increased | systematic mutation set | null Allele: tim8-Δ | S288C | threonine | Mülleder M, et al. (2016) PMID:27693354 | |
| chemical compound accumulation: increased | systematic mutation set | null Allele: tim8-Δ | S288C | proline | Mülleder M, et al. (2016) PMID:27693354 | |
| chemical compound accumulation: increased | systematic mutation set | null Allele: tim8-Δ | S288C | asparagine | Mülleder M, et al. (2016) PMID:27693354 | |
| chemical compound accumulation: increased | classical genetics | null Allele: tim8-Δ | S288C | reactive oxygen species | Details: increased intracellular ROS level in the null mutant compared to wt, an indicator of elevated oxidative stress | Tang D, et al. (2025) PMID:40001574 |
| chronological lifespan: decreased | classical genetics | null Allele: tim8-Δ | S288C | Details: CLS, the length of time a population of yeast cells remains viable in the stationary phase, is reduced from more than 30 days in wt cells to less than 9 days in the null mutant | Tang D, et al. (2025) PMID:40001574 | |
| chronological lifespan: increased | classical genetics | null Allele: tim8-Δ | S288C | 1.5 μM tunicamycin | Details: CLS, the length of time a population of yeast cells remains viable in the stationary phase, is increased from 9 to 21 days in the null mutant while CLS is reduced in wt cells from 30 to 21 days in tunicamycin-treated cells | Tang D, et al. (2025) PMID:40001574 |
| growth in exponential phase: increased rate | classical genetics | null Allele: tim8-Δ | S288C | Details: null mutant enters exponential phase earlier and displays an increased rate of growth relative to wt | Tang D, et al. (2025) PMID:40001574 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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