Sequence Help

SEM1 / YDR363W-A Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

DSS1 10 , HOD1
Protein Product
proteasome regulatory particle lid subunit SEM1
Feature Type
ORF , Verified
19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA export, and in the prevention of transcription-associated genome instability; ubiquitinated by Nedd4-like E3-ligase, Rsp5p; human ortholog DSS1, a BRCA1 binding protein implicated in cancer, complements the yeast null; drives trinucleotide repeat expansion; protein abundance increases in response to DNA replication stress 1 2 3 4 5 6 7 8 9