Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
23 entries for 13 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| cell cycle progression in S phase: abnormal | large-scale survey | repressible | S288C | Details: accumulation of cells with a DNA content between 1C and 2C indicative of an S phase delay | Yu L, et al. (2006) PMID:16943325 | |
| cell cycle progression in S phase: delayed | classical genetics | conditional Allele: dpb2-103 T342I, S343F, T345I, P347S, P348S; proline-rich region mutated | Other | Temperature: elevated temperature, 37 °C Treatment: alpha-factor block release Details: after synchronous release at elevated temperature, cells progressed much more slowly through S phase and arrest with a nearly 2C DNA content or greater | Jaszczur M, et al. (2008) PMID:18245343 | |
| cellular morphology: abnormal | classical genetics | conditional Allele: dpb2-1 D300N, K521R, V565F, G662R | Other | Temperature: elevated temperature, 38 °C Details: dumbbell shaped cells with nuclei near or in the bud neck | Araki H, et al. (1991) PMID:2052544 | |
| cellular morphology: abnormal | classical genetics | conditional Allele: dpb2-103 T342I, S343F, T345I, P347S, P348S; proline-rich region mutated | Other | Temperature: elevated temperature, 37 °C Details: arrest with dumbbell-shaped morphology and the nucleus between mother and daughter cells | Jaszczur M, et al. (2008) PMID:18245343 | |
| cellular morphology: abnormal | classical genetics | conditional Allele: dpb2-100 L284P, T345A | Other | Temperature: elevated temperature, 37 °C Details: arrest with dumbbell-shaped morphology and the nucleus between mother and daughter cells | Jaszczur M, et al. (2008) PMID:18245343 | |
| chromosome/plasmid maintenance: decreased | large-scale survey | repressible | S288C | 10 ug/ml doxycycline | Details: Tet-regulated essential ORF strain collection (doxycycline represses expression)|; increased chromosome rearrangements and chromosome loss, as measured in an illegitimate mating assay | Cheng E, et al. (2012) PMID:22673806 |
| competitive fitness: increased | competitive growth fitness profiling of essential genes using hypomorphic DAmP alleles | reduction of function | S288C | Media: minimal medium Details: Relative fitness score: 1.013 | Breslow DK, et al. (2008) PMID:18622397 | |
| heat sensitivity: increased | classical genetics | conditional Allele: dpb2-100 L284P, T345A | S288C | Temperature: elevated temperature, 37 °C Details: exhibits clear temperature sensitivity | Jaszczur M, et al. (2008) PMID:18245343 | |
| heat sensitivity: increased | classical genetics | conditional Allele: dpb2-101 L284P | S288C | Temperature: elevated temperature, 37 °C Details: moderate temperature sensitivity with slow growth at the restrictive temperature | Jaszczur M, et al. (2008) PMID:18245343 | |
| heat sensitivity: increased | classical genetics | conditional Allele: dpb2-103 T342I, S343F, T345I, P347S, P348S; proline-rich region mutated | S288C | Temperature: elevated temperature, 37 °C Details: exhibits clear temperature sensitivity | Jaszczur M, et al. (2008) PMID:18245343 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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