Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
36 entries for 19 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| chemical compound accumulation: decreased | classical genetics | null Allele: taz1-Δ | W303 | cardiolipin | de Taffin de Tilques M, et al. (2017) PMID:28188263 | |
| chemical compound accumulation: decreased | classical genetics | null Allele: taz1-Δ | W303 | reactive oxygen species | Treatment: microaerobic conditions Details: decrease in ROS levels in the null mutant cultured under microaerobic conditions | Venkatraman K and Budin I (2024) PMID:39038656 |
| chemical compound accumulation: decreased | classical genetics | null Allele: taz1-Δ | W303 | cardiolipin | Treatment: aerobic conditions Details: ~50% reduction in cardiolipin levels in the null mutant cultured under aerobic conditions; returned to wt levels in a taz1-Δ ddl1-Δ double mutant | Venkatraman K and Budin I (2024) PMID:39038656 |
| chemical compound accumulation: decreased | classical genetics | null Allele: taz1-Δ | W303 | cardiolipin | Treatment: microaerobic conditions Details: ~75% reduction in cardiolipin levels in the null mutant cultured under microaerobic conditions | Venkatraman K and Budin I (2024) PMID:39038656 |
| chemical compound accumulation: increased | classical genetics | null Allele: taz1-Δ | S288C | 2-monolysocardiolipin | Details: in mitochondria | Beranek A, et al. (2009) PMID:19244244 |
| chemical compound accumulation: increased | classical genetics | null Allele: taz1-Δ | W303 | phosphatidylinositol | de Taffin de Tilques M, et al. (2017) PMID:28188263 | |
| chemical compound accumulation: increased | classical genetics | null Allele: taz1-Δ | W303 | reactive oxygen species | de Taffin de Tilques M, et al. (2017) PMID:28188263 | |
| chemical compound accumulation: increased | classical genetics | null Allele: taz1-Δ | W303 | phosphatidylglycerol | Treatment: microaerobic conditions Details: loss of cardiolipin is coupled with increased levels of phosphatidylglycerol in the null mutant cultured under microaerobic conditions | Venkatraman K and Budin I (2024) PMID:39038656 |
| chromosome/plasmid maintenance: decreased | heterozygous diploid, systematic mutation set | null Allele: taz1-Δ | S288C | Assay: diploid bimater (BiM) assay Details: haploinsufficiency results in chromosome instability (CIN); scored >= 2 standard deviations above the mean | Choy JS, et al. (2013) PMID:23825022 | |
| colony sectoring: increased | heterozygous diploid, systematic mutation set | null Allele: taz1-Δ | S288C | Assay: quantitative chromosome transmission fidelity (qCTF) assay Details: >1.5 fold increase in mini-chromosome loss relative to wt, indicative of chromosome instability (CIN) | Zhu J, et al. (2015) PMID:25823586 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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