Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
11 entries for 9 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| budding index: decreased | homozygous diploid, large-scale survey | null Allele: ypl257w-Δ | S288C | Zettel MF, et al. (2003) PMID:12829295 | ||
| chemical compound accumulation: increased | homozygous diploid | null Allele: ypl257w-Δ | S288C | cobalt(2+) | Treatment: cobalt dichloride, 1 mM Details: cobalt sensitive null mutant accumulates cobalt after treatment with CoCl2 for 12 hrs | Zhao YY, et al. (2020) PMID:31904504 |
| competitive fitness: decreased | systematic mutation set | null Allele: ypl257w-Δ | S288C | Media: synthetic oak exudate medium, OAK | Qian W, et al. (2012) PMID:23103169 | |
| competitive fitness: increased | competitive growth fitness profiling using complete deletion alleles | null Allele: ypl257w-Δ | S288C | Media: minimal medium Details: Relative fitness score: 1.001 | Breslow DK, et al. (2008) PMID:18622397 | |
| haploinsufficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: ypl257w-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: -0.003 | Pir P, et al. (2012) PMID:22244311 | |
| resistance to chemicals: decreased | competitive growth | overexpression | S288C | 1.3 nM sirolimus | Details: sirolimus is rapamycin | Butcher RA, et al. (2006) PMID:16415861 |
| resistance to chemicals: decreased | homozygous diploid, competitive growth | null Allele: ypl257w-Δ | S288C | 2.3 mM mono(2-ethylhexyl) phthalate | Details: MEHP sensitive with fitness coefficient (logFC) < 0.5 and P-value < 0.05 | Alfatah M, et al. (2019) PMID:31029968 |
| resistance to chemicals: decreased | homozygous diploid, systematic mutation set | null Allele: ypl257w-Δ | S288C | 2 mM cobalt dichloride | Details: cobalt sensitive relative to wt | Zhao YY, et al. (2020) PMID:31904504 |
| resistance to chemicals: increased | large-scale survey | null Allele: ypl257w-Δ | S288C | 5 ug/ml L-canavanine | Shi Y, et al. (2011) PMID:21880895 | |
| vacuolar morphology: abnormal | systematic mutation set screen all non-essential genes for inability to fragment vacuoles in response to salt addition | null Allele: ypl257w-Δ | S288C | 0.4 M sodium chloride | Details: small defect in vacuolar fragmentation | Michaillat L and Mayer A (2013) PMID:23383298 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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