Literature Help
AFT2 / YPL202C Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Hsu PC, et al. (2024) Protein moonlighting by a target gene dominates phenotypic divergence of the Sef1 transcriptional regulatory network in yeasts. Nucleic Acids Res 52(22):13914-13930 PMID:39565215
- Yang X, et al. (2022) Downregulation of EHT1 and EEB1 in Saccharomyces cerevisiae Alters the Ester Profile of Wine during Fermentation. J Microbiol Biotechnol 32(6):761-767 PMID:35484971
- Pujol-Carrion N, et al. (2021) The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1. Biochim Biophys Acta Mol Cell Res 1868(5):118974 PMID:33549702
- Li L, et al. (2020) The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1. J Biol Chem 295(6):1716-1726 PMID:31896574
- Taymaz-Nikerel H, et al. (2020) Insights Into the Mechanism of Anticancer Drug Imatinib Revealed Through Multi-Omic Analyses in Yeast. OMICS 24(11):667-678 PMID:32991258
- Li H and Outten CE (2019) The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2. J Biol Inorg Chem 24(6):809-815 PMID:31493153
- Chi CB, et al. (2018) Structural and Biochemical Insights into the Multiple Functions of Yeast Grx3. J Mol Biol 430(8):1235-1248 PMID:29524511
- Deepa A, et al. (2018) DNA repair activity of Fe(II)/2OG-dependent dioxygenases affected by low iron level in Saccharomyces cerevisiae. FEMS Yeast Res 18(2) PMID:29438506
- Mohammad H, et al. (2018) Discovery of a Novel Dibromoquinoline Compound Exhibiting Potent Antifungal and Antivirulence Activity That Targets Metal Ion Homeostasis. ACS Infect Dis 4(3):403-414 PMID:29370698
- Wang Y, et al. (2018) The cellular economy of the Saccharomyces cerevisiae zinc proteome. Metallomics 10(12):1755-1776 PMID:30358795
- Tardiff DF, et al. (2017) Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism. ACS Chem Neurosci 8(9):2039-2055 PMID:28628299
- Yadav PK and Rajasekharan R (2017) The m6A methyltransferase Ime4 epitranscriptionally regulates triacylglycerol metabolism and vacuolar morphology in haploid yeast cells. J Biol Chem 292(33):13727-13744 PMID:28655762
- Mülleder M, et al. (2016) Functional Metabolomics Describes the Yeast Biosynthetic Regulome. Cell 167(2):553-565.e12 PMID:27693354
- Pérez-Sampietro M, et al. (2016) The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system. Sci Rep 6:32836 PMID:27618952
- Yadav PK and Rajasekharan R (2016) Misregulation of a DDHD Domain-containing Lipase Causes Mitochondrial Dysfunction in Yeast. J Biol Chem 291(35):18562-81 PMID:27402848
- An X, et al. (2015) The late-annotated small ORF LSO1 is a target gene of the iron regulon of Saccharomyces cerevisiae. Microbiologyopen 4(6):941-51 PMID:26450372
- Poor CB, et al. (2014) Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2. Proc Natl Acad Sci U S A 111(11):4043-8 PMID:24591629
- Batista-Nascimento L, et al. (2013) Yeast protective response to arsenate involves the repression of the high affinity iron uptake system. Biochim Biophys Acta 1833(5):997-1005 PMID:23295455
- O'Doherty PJ, et al. (2013) Transcriptomic insights into the molecular response of Saccharomyces cerevisiae to linoleic acid hydroperoxide. Free Radic Res 47(12):1054-65 PMID:24074273
- Castells-Roca L, et al. (2011) The oxidative stress response in yeast cells involves changes in the stability of Aft1 regulon mRNAs. Mol Microbiol 81(1):232-48 PMID:21542867
- GO Annotation Working Group (2011) Manual annotations that require more than one source of functional data to support the assignment of the associated GO term.
- Conde e Silva N, et al. (2009) KlAft, the Kluyveromyces lactis ortholog of Aft1 and Aft2, mediates activation of iron-responsive transcription through the PuCACCC Aft-type sequence. Genetics 183(1):93-106 PMID:19581449
- Babu MM, et al. (2006) The natural history of the WRKY-GCM1 zinc fingers and the relationship between transcription factors and transposons. Nucleic Acids Res 34(22):6505-20 PMID:17130173
- Dubacq C, et al. (2006) Role of the iron mobilization and oxidative stress regulons in the genomic response of yeast to hydroxyurea. Mol Genet Genomics 275(2):114-24 PMID:16328372
- Courel M, et al. (2005) Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol 25(15):6760-71 PMID:16024809
- Puig S, et al. (2005) Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation. Cell 120(1):99-110 PMID:15652485
- Rutherford JC, et al. (2005) Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis. J Biol Chem 280(11):10135-40 PMID:15649888
- Rutherford JC, et al. (2003) Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. J Biol Chem 278(30):27636-43 PMID:12756250
- Portnoy ME, et al. (2002) The distinct methods by which manganese and iron regulate the Nramp transporters in yeast. Biochem J 362(Pt 1):119-24 PMID:11829747
- Blaiseau PL, et al. (2001) Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem 276(36):34221-6 PMID:11448968
- Rutherford JC, et al. (2001) A second iron-regulatory system in yeast independent of Aft1p. Proc Natl Acad Sci U S A 98(25):14322-7 PMID:11734641
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
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Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- McGee CC, et al. (2025) Cysteine import via the high-affinity GSH transporter Hgt1 rescues GSH auxotrophy in yeast. J Biol Chem 301(2):108131 PMID:39716489
- Hou S, et al. (2024) Med3-mediated NADPH generation to help Saccharomyces cerevisiae tolerate hyperosmotic stress. Appl Environ Microbiol 90(8):e0096824 PMID:39082808
- McLean S, et al. (2024) Molecular mechanisms of genotype-dependent lifespan variation mediated by caloric restriction: insight from wild yeast isolates. Front Aging 5:1408160 PMID:39055969
- Lindahl PA and Vali SW (2022) Mössbauer-based molecular-level decomposition of the Saccharomyces cerevisiae ironome, and preliminary characterization of isolated nuclei. Metallomics 14(11) PMID:36214417
- Romero AM, et al. (2022) Changes in mRNA stability play an important role in the adaptation of yeast cells to iron deprivation. Biochim Biophys Acta Gene Regul Mech 1865(2):194800 PMID:35218933
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Yamada R, et al. (2021) Improvement of lactic acid tolerance by cocktail δ-integration strategy and identification of the transcription factor PDR3 responsible for lactic acid tolerance in yeast Saccharomyces cerevisiae. World J Microbiol Biotechnol 37(2):19 PMID:33428004
- Yang YX, et al. (2020) Metabolomic profiling reveals similar cytotoxic effects and protective functions of quercetin during deoxynivalenol- and 15-acetyl deoxynivalenol-induced cell apoptosis. Toxicol In Vitro 66:104838 PMID:32229167
- Albetel AN and Outten CE (2018) Characterization of Glutaredoxin Fe-S Cluster-Binding Interactions Using Circular Dichroism Spectroscopy. Methods Enzymol 599:327-353 PMID:29746245
- Benchouaia M, et al. (2018) Comparative Transcriptomics Highlights New Features of the Iron Starvation Response in the Human Pathogen Candida glabrata. Front Microbiol 9:2689 PMID:30505294
- Hou YK, et al. (2018) LiMn0.8Fe0.2PO4/Carbon Nanospheres@Graphene Nanoribbons Prepared by the Biomineralization Process as the Cathode for Lithium-Ion Batteries. ACS Appl Mater Interfaces 10(19):16500-16510 PMID:29693376
- McIsaac RS, et al. (2016) From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span. Ann N Y Acad Sci 1363:155-70 PMID:26995762
- Ozer HK, et al. (2015) Cytosolic Fe-S Cluster Protein Maturation and Iron Regulation Are Independent of the Mitochondrial Erv1/Mia40 Import System. J Biol Chem 290(46):27829-40 PMID:26396185
- Wofford JD and Lindahl PA (2015) Mitochondrial Iron-Sulfur Cluster Activity and Cytosolic Iron Regulate Iron Traffic in Saccharomyces cerevisiae. J Biol Chem 290(45):26968-26977 PMID:26306041
- Foster AW, et al. (2014) A chemical potentiator of copper-accumulation used to investigate the iron-regulons of Saccharomyces cerevisiae. Mol Microbiol 93(2):317-30 PMID:24895027
- Gonçalves IR, et al. (2014) The basis for evolution of DNA-binding specificity of the Aft1 transcription factor in yeasts. Genetics 196(1):149-60 PMID:24172132
- Slavov N, et al. (2014) Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis. Cell Rep 7(3):705-14 PMID:24767987
- Zhang Y, et al. (2014) Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc Natl Acad Sci U S A 111(17):E1695-704 PMID:24733891
- Lai WK and Buck MJ (2013) An integrative approach to understanding the combinatorial histone code at functional elements. Bioinformatics 29(18):2231-7 PMID:23821650
- Qi J, et al. (2012) Metal-sensing transcription factors Mac1p and Aft1p coordinately regulate vacuolar copper transporter CTR2 in Saccharomyces cerevisiae. Biochem Biophys Res Commun 423(2):424-8 PMID:22683637
- Sharon E, et al. (2012) Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters. Nat Biotechnol 30(6):521-30 PMID:22609971
- de Souza AP, et al. (2012) Strategies to select yeast starters cultures for production of flavor compounds in cachaça fermentations. Antonie Van Leeuwenhoek 101(2):379-92 PMID:21932076
- Achcar F, et al. (2011) A Boolean probabilistic model of metabolic adaptation to oxygen in relation to iron homeostasis and oxidative stress. BMC Syst Biol 5:51 PMID:21489274
- Carreto L, et al. (2011) Expression variability of co-regulated genes differentiates Saccharomyces cerevisiae strains. BMC Genomics 12:201 PMID:21507216
- Contador CA, et al. (2011) Identification of transcription factors perturbed by the synthesis of high levels of a foreign protein in yeast Saccharomyces cerevisiae. Biotechnol Prog 27(4):925-36 PMID:21656919
- Dhaoui M, et al. (2011) Gex1 is a yeast glutathione exchanger that interferes with pH and redox homeostasis. Mol Biol Cell 22(12):2054-67 PMID:21490148
- Gordân R, et al. (2011) Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol 12(12):R125 PMID:22189060
- Kumar C, et al. (2011) Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control. EMBO J 30(10):2044-56 PMID:21478822
- Miller C, et al. (2011) Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in yeast. Mol Syst Biol 7:458 PMID:21206491
- Rahat O, et al. (2011) Multiple pathways regulating the calorie restriction response in yeast. J Gerontol A Biol Sci Med Sci 66(2):163-9 PMID:21081478
- Ratnakumar S, et al. (2011) Phenomic and transcriptomic analyses reveal that autophagy plays a major role in desiccation tolerance in Saccharomyces cerevisiae. Mol Biosyst 7(1):139-49 PMID:20963216
- Ayer A, et al. (2010) The critical role of glutathione in maintenance of the mitochondrial genome. Free Radic Biol Med 49(12):1956-68 PMID:20888410
- Babbitt GA (2010) Relaxed selection against accidental binding of transcription factors with conserved chromatin contexts. Gene 466(1-2):43-8 PMID:20637845
- Berthelet S, et al. (2010) Functional genomics analysis of the Saccharomyces cerevisiae iron responsive transcription factor Aft1 reveals iron-independent functions. Genetics 185(3):1111-28 PMID:20439772
- Fordyce PM, et al. (2010) De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis. Nat Biotechnol 28(9):970-5 PMID:20802496
- Franken J and Bauer FF (2010) Carnitine supplementation has protective and detrimental effects in Saccharomyces cerevisiae that are genetically mediated. FEMS Yeast Res 10(3):270-81 PMID:20199579
- Liang Y, et al. (2010) Role of Candida albicans Aft2p transcription factor in ferric reductase activity, morphogenesis and virulence. Microbiology (Reading) 156(Pt 10):2912-2919 PMID:20595261
- Morris RT, et al. (2010) Ceres: software for the integrated analysis of transcription factor binding sites and nucleosome positions in Saccharomyces cerevisiae. Bioinformatics 26(2):168-74 PMID:19959498
- Rosenfeld L, et al. (2010) The effect of phosphate accumulation on metal ion homeostasis in Saccharomyces cerevisiae. J Biol Inorg Chem 15(7):1051-62 PMID:20429018
- Zheng J, et al. (2010) Epistatic relationships reveal the functional organization of yeast transcription factors. Mol Syst Biol 6:420 PMID:20959818
- Gordân R, et al. (2009) Distinguishing direct versus indirect transcription factor-DNA interactions. Genome Res 19(11):2090-100 PMID:19652015
- Jothi R, et al. (2009) Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture. Mol Syst Biol 5:294 PMID:19690563
- Mak HC, et al. (2009) Dynamic reprogramming of transcription factors to and from the subtelomere. Genome Res 19(6):1014-25 PMID:19372386
- Veatch JR, et al. (2009) Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 137(7):1247-58 PMID:19563757
- Andrew AJ, et al. (2008) Posttranslational regulation of the scaffold for Fe-S cluster biogenesis, Isu. Mol Biol Cell 19(12):5259-66 PMID:18843040
- Gibson BR, et al. (2008) The oxidative stress response of a lager brewing yeast strain during industrial propagation and fermentation. FEMS Yeast Res 8(4):574-85 PMID:18373683
- Lu CC, et al. (2008) Extracting transcription factor binding sites from unaligned gene sequences with statistical models. BMC Bioinformatics 9 Suppl 12(Suppl 12):S7 PMID:19091030
- Puig S, et al. (2008) Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency. Cell Metab 7(6):555-64 PMID:18522836
- Salin H, et al. (2008) Structure and properties of transcriptional networks driving selenite stress response in yeasts. BMC Genomics 9:333 PMID:18627600
- Zhao Y, et al. (2008) Development of a novel oligonucleotide array-based transcription factor assay platform for genome-wide active transcription factor profiling in Saccharomyces cerevisiae. J Proteome Res 7(3):1315-25 PMID:18220337
- Ernst J, et al. (2007) Reconstructing dynamic regulatory maps. Mol Syst Biol 3:74 PMID:17224918
- Ueta R, et al. (2007) Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae. Mol Biol Cell 18(8):2980-90 PMID:17538022
- Kresnowati MT, et al. (2006) When transcriptome meets metabolome: fast cellular responses of yeast to sudden relief of glucose limitation. Mol Syst Biol 2:49 PMID:16969341
- Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 PMID:16823961
- Yu H and Gerstein M (2006) Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A 103(40):14724-31 PMID:17003135
- van Bakel H, et al. (2005) Gene expression profiling and phenotype analyses of S. cerevisiae in response to changing copper reveals six genes with new roles in copper and iron metabolism. Physiol Genomics 22(3):356-67 PMID:15886332
- De Freitas JM, et al. (2004) Exploratory and confirmatory gene expression profiling of mac1Delta. J Biol Chem 279(6):4450-8 PMID:14534306
- Sickmann A, et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 PMID:14576278
Reviews
No reviews curated.
Download References (.nbib)
- Dancis A, et al. (2024) Mitochondria function in cytoplasmic FeS protein biogenesis. Biochim Biophys Acta Mol Cell Res 1871(5):119733 PMID:38641180
- Melo NTM, et al. (2024) Just around the Corner: Advances in the Optimization of Yeasts and Filamentous Fungi for Lactic Acid Production. J Fungi (Basel) 10(3) PMID:38535215
- Pijuan J, et al. (2023) Regulatory and pathogenic mechanisms in response to iron deficiency and excess in fungi. Microb Biotechnol 16(11):2053-2071 PMID:37804207
- Schulz V, et al. (2023) Mitochondrial [2Fe-2S] ferredoxins: new functions for old dogs. FEBS Lett 597(1):102-121 PMID:36443530
- Xue P, et al. (2023) Heme sensing and trafficking in fungi. Fungal Biol Rev 43 PMID:37781717
- Sanz AB, et al. (2022) Control of Gene Expression via the Yeast CWI Pathway. Int J Mol Sci 23(3) PMID:35163713
- Biz A and Mahadevan R (2021) Overcoming Challenges in Expressing Iron-Sulfur Enzymes in Yeast. Trends Biotechnol 39(7):665-677 PMID:33339619
- Gupta M and Outten CE (2020) Iron-sulfur cluster signaling: The common thread in fungal iron regulation. Curr Opin Chem Biol 55:189-201 PMID:32234663
- Mühlenhoff U, et al. (2020) Glutaredoxins and iron-sulfur protein biogenesis at the interface of redox biology and iron metabolism. Biol Chem 401(12):1407-1428 PMID:33031050
- Ramos-Alonso L, et al. (2020) Iron Regulatory Mechanisms in Saccharomyces cerevisiae. Front Microbiol 11:582830 PMID:33013818
- Mao Y and Chen C (2019) The Hap Complex in Yeasts: Structure, Assembly Mode, and Gene Regulation. Front Microbiol 10:1645 PMID:31379791
- Rey P, et al. (2019) Is There a Role for Glutaredoxins and BOLAs in the Perception of the Cellular Iron Status in Plants? Front Plant Sci 10:712 PMID:31231405
- Li L and Ward DM (2018) Iron toxicity in yeast: transcriptional regulation of the vacuolar iron importer Ccc1. Curr Genet 64(2):413-416 PMID:29043483
- Martins TS, et al. (2018) Signaling pathways governing iron homeostasis in budding yeast. Mol Microbiol 109(4):422-432 PMID:29995317
- Ciesielski SJ and Craig EA (2017) Posttranslational control of the scaffold for Fe-S cluster biogenesis as a compensatory regulatory mechanism. Curr Genet 63(1):51-56 PMID:27246605
- Taymaz-Nikerel H, et al. (2016) Genome-Wide Transcriptional Response of Saccharomyces cerevisiae to Stress-Induced Perturbations. Front Bioeng Biotechnol 4:17 PMID:26925399
- Zhang C (2014) Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control. Protein Cell 5(10):750-60 PMID:25000876
- Cyert MS and Philpott CC (2013) Regulation of cation balance in Saccharomyces cerevisiae. Genetics 193(3):677-713 PMID:23463800
- Dlouhy AC and Outten CE (2013) The iron metallome in eukaryotic organisms. Met Ions Life Sci 12:241-78 PMID:23595675
- Martínez-Pastor MT, et al. (2013) Post-transcriptional regulation of iron homeostasis in Saccharomyces cerevisiae. Int J Mol Sci 14(8):15785-809 PMID:23903042
- Outten CE and Albetel AN (2013) Iron sensing and regulation in Saccharomyces cerevisiae: Ironing out the mechanistic details. Curr Opin Microbiol 16(6):662-8 PMID:23962819
- Li H and Outten CE (2012) Monothiol CGFS glutaredoxins and BolA-like proteins: [2Fe-2S] binding partners in iron homeostasis. Biochemistry 51(22):4377-89 PMID:22583368
- Philpott CC, et al. (2012) Metabolic remodeling in iron-deficient fungi. Biochim Biophys Acta 1823(9):1509-20 PMID:22306284
- Salvail H and Massé E (2012) Regulating iron storage and metabolism with RNA: an overview of posttranscriptional controls of intracellular iron homeostasis. Wiley Interdiscip Rev RNA 3(1):26-36 PMID:21793218
- Ehrensberger KM and Bird AJ (2011) Hammering out details: regulating metal levels in eukaryotes. Trends Biochem Sci 36(10):524-31 PMID:21840721
- Murray DB, et al. (2011) Redox regulation in respiring Saccharomyces cerevisiae. Biochim Biophys Acta 1810(10):945-58 PMID:21549177
- Philpott CC and Protchenko O (2008) Response to iron deprivation in Saccharomyces cerevisiae. Eukaryot Cell 7(1):20-7 PMID:17993568
- Vergara SV and Thiele DJ (2008) Post-transcriptional regulation of gene expression in response to iron deficiency: co-ordinated metabolic reprogramming by yeast mRNA-binding proteins. Biochem Soc Trans 36(Pt 5):1088-90 PMID:18793194
- Kaplan J, et al. (2006) Iron-dependent metabolic remodeling in S. cerevisiae. Biochim Biophys Acta 1763(7):646-51 PMID:16697062
- Kaplan CD and Kaplan J (2005) Regulatory oversight of the iron trade: posttranscriptional regulation in yeast. Cell Metab 2(1):4-6 PMID:16054093
- Massé E and Arguin M (2005) Ironing out the problem: new mechanisms of iron homeostasis. Trends Biochem Sci 30(8):462-8 PMID:15996868
- Rutherford JC and Bird AJ (2004) Metal-responsive transcription factors that regulate iron, zinc, and copper homeostasis in eukaryotic cells. Eukaryot Cell 3(1):1-13 PMID:14871932
- Schröder I, et al. (2003) Microbial ferric iron reductases. FEMS Microbiol Rev 27(2-3):427-47 PMID:12829278
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Download References (.nbib)
- Li H and Outten CE (2019) The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2. J Biol Inorg Chem 24(6):809-815 PMID:31493153
- Wang Y, et al. (2018) The cellular economy of the Saccharomyces cerevisiae zinc proteome. Metallomics 10(12):1755-1776 PMID:30358795
- Pérez-Sampietro M, et al. (2016) The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system. Sci Rep 6:32836 PMID:27618952
- Yadav PK and Rajasekharan R (2016) Misregulation of a DDHD Domain-containing Lipase Causes Mitochondrial Dysfunction in Yeast. J Biol Chem 291(35):18562-81 PMID:27402848
- Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 PMID:16823961
- Courel M, et al. (2005) Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol 25(15):6760-71 PMID:16024809
- Sickmann A, et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 PMID:14576278
- Blaiseau PL, et al. (2001) Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem 276(36):34221-6 PMID:11448968
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Download References (.nbib)
- Yang YX, et al. (2020) Metabolomic profiling reveals similar cytotoxic effects and protective functions of quercetin during deoxynivalenol- and 15-acetyl deoxynivalenol-induced cell apoptosis. Toxicol In Vitro 66:104838 PMID:32229167
- Pérez-Sampietro M, et al. (2016) The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system. Sci Rep 6:32836 PMID:27618952
- Yadav PK and Rajasekharan R (2016) Misregulation of a DDHD Domain-containing Lipase Causes Mitochondrial Dysfunction in Yeast. J Biol Chem 291(35):18562-81 PMID:27402848
- Courel M, et al. (2005) Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol 25(15):6760-71 PMID:16024809
- Rutherford JC, et al. (2001) A second iron-regulatory system in yeast independent of Aft1p. Proc Natl Acad Sci U S A 98(25):14322-7 PMID:11734641
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- O'Brien MJ and Ansari A (2024) Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle. Biochim Biophys Acta Proteins Proteom 1872(1):140968 PMID:37863410
- Li H and Outten CE (2019) The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2. J Biol Inorg Chem 24(6):809-815 PMID:31493153
- Chi CB, et al. (2018) Structural and Biochemical Insights into the Multiple Functions of Yeast Grx3. J Mol Biol 430(8):1235-1248 PMID:29524511
- Deepa A, et al. (2018) DNA repair activity of Fe(II)/2OG-dependent dioxygenases affected by low iron level in Saccharomyces cerevisiae. FEMS Yeast Res 18(2) PMID:29438506
- Miller JE, et al. (2018) Genome-Wide Mapping of Decay Factor-mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4. G3 (Bethesda) 8(1):315-330 PMID:29158339
- Shulist K, et al. (2017) Interrogation of γ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment. Sci Rep 7(1):11398 PMID:28900268
- Yadav PK and Rajasekharan R (2017) The m6A methyltransferase Ime4 epitranscriptionally regulates triacylglycerol metabolism and vacuolar morphology in haploid yeast cells. J Biol Chem 292(33):13727-13744 PMID:28655762
- Youn JY, et al. (2017) Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library. G3 (Bethesda) 7(3):911-921 PMID:28122947
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Mattiazzi Ušaj M, et al. (2015) Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis. Metallomics 7(9):1338-51 PMID:26067383
- Poor CB, et al. (2014) Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2. Proc Natl Acad Sci U S A 111(11):4043-8 PMID:24591629
- Zhang Y, et al. (2014) Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc Natl Acad Sci U S A 111(17):E1695-704 PMID:24733891
- Willmund F, et al. (2013) The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis. Cell 152(1-2):196-209 PMID:23332755
- Hoppins S, et al. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2):323-40 PMID:21987634
- Bandyopadhyay S, et al. (2010) Rewiring of genetic networks in response to DNA damage. Science 330(6009):1385-9 PMID:21127252
- Berthelet S, et al. (2010) Functional genomics analysis of the Saccharomyces cerevisiae iron responsive transcription factor Aft1 reveals iron-independent functions. Genetics 185(3):1111-28 PMID:20439772
- Costanzo M, et al. (2010) The genetic landscape of a cell. Science 327(5964):425-31 PMID:20093466
- Zheng J, et al. (2010) Epistatic relationships reveal the functional organization of yeast transcription factors. Mol Syst Biol 6:420 PMID:20959818
- Hasegawa Y, et al. (2008) Distinct roles for Khd1p in the localization and expression of bud-localized mRNAs in yeast. RNA 14(11):2333-47 PMID:18805955
- Johansson MJ, et al. (2007) Association of yeast Upf1p with direct substrates of the NMD pathway. Proc Natl Acad Sci U S A 104(52):20872-7 PMID:18087042
- Dubacq C, et al. (2006) Role of the iron mobilization and oxidative stress regulons in the genomic response of yeast to hydroxyurea. Mol Genet Genomics 275(2):114-24 PMID:16328372
- Courel M, et al. (2005) Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol 25(15):6760-71 PMID:16024809
- Zhao R, et al. (2005) Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell 120(5):715-27 PMID:15766533
- Portnoy ME, et al. (2002) The distinct methods by which manganese and iron regulate the Nramp transporters in yeast. Biochem J 362(Pt 1):119-24 PMID:11829747
- Blaiseau PL, et al. (2001) Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem 276(36):34221-6 PMID:11448968
- Rutherford JC, et al. (2001) A second iron-regulatory system in yeast independent of Aft1p. Proc Natl Acad Sci U S A 98(25):14322-7 PMID:11734641
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
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- Li L, et al. (2020) The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1. J Biol Chem 295(6):1716-1726 PMID:31896574
- Yadav PK and Rajasekharan R (2017) The m6A methyltransferase Ime4 epitranscriptionally regulates triacylglycerol metabolism and vacuolar morphology in haploid yeast cells. J Biol Chem 292(33):13727-13744 PMID:28655762
- Yadav PK and Rajasekharan R (2016) Misregulation of a DDHD Domain-containing Lipase Causes Mitochondrial Dysfunction in Yeast. J Biol Chem 291(35):18562-81 PMID:27402848
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
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- Goh CJH, et al. (2022) Diethyl phthalate (DEP) perturbs nitrogen metabolism in Saccharomyces cerevisiae. Sci Rep 12(1):10237 PMID:35715465
- Campos SE, et al. (2018) Genomewide mechanisms of chronological longevity by dietary restriction in budding yeast. Aging Cell 17(3):e12749 PMID:29575540
- Chakrabortee S, et al. (2016) Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits. Cell 167(2):369-381.e12 PMID:27693355
- Duffy S, et al. (2016) Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. Proc Natl Acad Sci U S A 113(36):9967-76 PMID:27551064
- Mülleder M, et al. (2016) Functional Metabolomics Describes the Yeast Biosynthetic Regulome. Cell 167(2):553-565.e12 PMID:27693354
- Hoepfner D, et al. (2014) High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions. Microbiol Res 169(2-3):107-20 PMID:24360837
- Tun NM, et al. (2013) Disulfide stress-induced aluminium toxicity: molecular insights through genome-wide screening of Saccharomyces cerevisiae. Metallomics 5(8):1068-75 PMID:23832094
- Douglas AC, et al. (2012) Functional analysis with a barcoder yeast gene overexpression system. G3 (Bethesda) 2(10):1279-89 PMID:23050238
- Pir P, et al. (2012) The genetic control of growth rate: a systems biology study in yeast. BMC Syst Biol 6:4 PMID:22244311
- Qian W, et al. (2012) The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep 2(5):1399-410 PMID:23103169
- Ratnakumar S, et al. (2011) Phenomic and transcriptomic analyses reveal that autophagy plays a major role in desiccation tolerance in Saccharomyces cerevisiae. Mol Biosyst 7(1):139-49 PMID:20963216
- Venters BJ, et al. (2011) A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell 41(4):480-92 PMID:21329885
- Alamgir M, et al. (2010) Chemical-genetic profile analysis of five inhibitory compounds in yeast. BMC Chem Biol 10:6 PMID:20691087
- Auesukaree C, et al. (2009) Genome-wide identification of genes involved in tolerance to various environmental stresses in Saccharomyces cerevisiae. J Appl Genet 50(3):301-10 PMID:19638689
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- Cipollina C, et al. (2008) Saccharomyces cerevisiae SFP1: at the crossroads of central metabolism and ribosome biogenesis. Microbiology (Reading) 154(Pt 6):1686-1699 PMID:18524923
- Sinha H, et al. (2008) Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast. Genetics 180(3):1661-70 PMID:18780730
- Hu Z, et al. (2007) Genetic reconstruction of a functional transcriptional regulatory network. Nat Genet 39(5):683-7 PMID:17417638
- Brown JA, et al. (2006) Global analysis of gene function in yeast by quantitative phenotypic profiling. Mol Syst Biol 2:2006.0001 PMID:16738548
- MacIsaac KD, et al. (2006) An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC Bioinformatics 7:113 PMID:16522208
- Mendiratta G, et al. (2006) The DNA-binding domain of the yeast Spt10p activator includes a zinc finger that is homologous to foamy virus integrase. J Biol Chem 281(11):7040-8 PMID:16415340
- Deutschbauer AM, et al. (2005) Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics 169(4):1915-25 PMID:15716499
- Lum PY, et al. (2004) Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell 116(1):121-37 PMID:14718172
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549